Virginia Man-Yee Lee, PhD

The John H. Ware 3rd Endowed Professor in Alzheimer's Research
University of Pennsylvania Perelman School of Medicine
Director, Center for Neurodegenerative Disease Research
Co-Director, Marian S. Ware Center for Alzheimer's Drug Discovery Program

Contact InformationCenter for Neurodegenerative Disease Research
3rd Floor, Maloney Building
3600 Spruce Street
Philadelphia, PA 19104-4283
Office: (215) 662-6427
Fax: (215) 349-5909

Specialty Division

Neuropathology, Cancer and Immunobiology

Research Expertise

Research Interests
Biology of tau, synucleins, TDP-43 and amyloid beta precursor proteins (APPs) in health and disease.

Key words: Alzheimer's disease; tauopathies; APP; Parkinson’s disease; synucleinopathies, amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, TDP-43 proteinopathies.

Description of Research
Dr. Lee’s research focuses on disease proteins that form pathological inclusions in hereditary and sporadic Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and related neurodegenerative disorders of aging. Her work demonstrated that tau, alpha-synuclein and TDP-43 proteins form unique brain aggregates in neurodegenerative diseases and provided critical evidence that aggregation of brain proteins is a common mechanistic theme in diverse neurodegenerative diseases including AD, PD, FTLD, ALS and related disorders. Significantly, Dr. Lee’s studies implicated the abnormal aggregation of tau, alpha-synuclein and TDP-43 in mechanisms that compromise neuronal viability. Most importantly, this research has opened up new avenues of research to identify targets for drug discovery to develop better treatments for these disorders.

Research Techniques
Protein biochemistry; cell and molecular biology; monoclonal antibody production; immunochemical and immunocytochemical techniques; tissue culture; transgenic mouse models; and electron microscopy.

Rotation Projects
Lab rotation projects are difficult to define in a rapidly moving field. Please contact Dr. Lee to discuss possible rotation projects.

Graduate Groups

Biochemistry and Molecular Biophysics
Cell and Molecular Biology


Specialty Certification

Postgraduate Training

Awards and Honors

Memberships and Professional Organizations

Web Links

Selected Publications

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