Michele E. Paessler, DO
Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information3401 Civic Center Boulevard
Suite 5199D
Philadelphia, PA 19104
Office: 267-426-7309
Fax: 215-590-2130
Email: paessler@email.chop.edu
Education
B.S. Muhlenberg College (with honors), Allentown, PA, 1993
D.O. Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 1997
Specialty Certification
Hematology/Hematopathology, 2004
Anatomic Pathology and Clinical Pathology, 2004
Molecular Genetic Pathology, 2005
Postgraduate Training
Intern in Medicine, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1997-1998
Resident in Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, 1998-2001
Chief Resident, Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, 2000-2001
Fellow, Molecular Pathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2001-2003
Fellow, Hematopathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2002-2003
Fellow, Molecular Genetic Pathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2003-2004
Awards and Honors
Deans List, Muhlenberg College, Allentown, PA, 1990-1993
Philadelphia College of Osteopathic Medicine Academic Scholarship, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1994-1997
William F. Daiber, D.O. Memorial Cardiology Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1997-1997
Sigma Xi Research Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1997-1997
Internship Cardiology/Critical Care Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1998-1998
William Pepper Clinical Laboratory Fellow, University of Pennsylvania Medical Center, Philadelphia PA, 2001-2001
2001 Resident Teaching Award, Dept of Pathology, University of Pennsylvania Medical Center, Philadelphia PA, 2001-2001
Memberships and Professional Organizations
Pennsylvania Osteopathic Medical Association, 1997 - Present
United States and Canadian Academy of Pathology, 2000 - Present
Association of Molecular Pathology, 2001 - 2004
American Society of Hematology, 2002 - Present
International Clinical Cytometry Society, 2005 - Present
Society for Pediatric Pathology, 2005 - Present
College of American Pathologists - Instrumentation Resource Committee, 2007 - Present
NAPAAC Aplastic Anemia Retrospective Analysis
Hematopathology Working Group Study, 2013 - present
Society of Hematopathology, 2015 - Present
International Society for Laboratory Hematology (ISLH), 2016 - Present
American Society of Clinical Pathology, 2022 - Present
Web Links
Selected Publications
Hodgkin Lymphoma Diagnosed by Endobronchial Ultrasound Guided Cryobiopsy, a Minimally Invasive Diagnostic Technique
Grant LMC, Bellissimo DC, Katz AJ, Daou AW, Margolskee E, Bernt KM, Piccione J, Pediatr Pulmonol 60(1): e27392, 2025, PMID:39526594
Optimal Carcinoembryonic Antigen (CEA) Cutoff Values in the Diagnosis of Neoplastic Mucinous Pancreatic Cysts Differ Among Assays
Kim D, Margolskee E, Goyal A, Siddiqui MT, Heymann JJ, Rao R, Hayden J, J Clin Pathol 77(12): 848-852, 2024, PMID:37940376
Serum Cytokine Panels in Pediatric Clinical Practice
Gallo PM, Kim J, McNerney KO, Diorio C, Foley C, Kagami L, Wagner K, Petrosa WL, Conlon H, Gollomp KL, Canna SW, Seif AE, Conrad MA, Kelsen JR, Romberg N, Bassiri H, Sullivan KE, Teachey DT, Paessler ME, Behrens EM, Lambert MP, J Allergy Clin Immunol, 2024, PMID:39303891
Uncovering the Genetic Etiology of Inherited Bone Marrow Failure Syndromes Using a Custom-Designed Next-Generation Sequencing Panel
Lin F, Cao K, Chang F, Oved JH, Luo M, Fan Z, Schubert J, Wu J, Zhong Y, Gallo DJ, Denenberg EH, Chen J, Fanning EA, Lambert MP, Paessler ME, Surrey LF, Zelley K, MacFarland S, Kurre P, Olson TS, Li MM, J Mol Diagn 26(3): 191-201, 2024, PMID:38103590
Haematology laboratory parameters to assess efficacy of CD19-, CD22-, CD33-, and CD123-directed chimeric antigen receptor T-cell therapy in haematological malignancies
Drumheller B, Gebre K, Lockhart B, Margolskee E, Obstfeld A, Paessler M, Pillai V, International Journal of Laboratory Hematology 44(4): 750-758, 2022, PMID:35419923
Transcriptome and Unique Cytokine Microenvironment of Castleman Disease
Wing A, Xu J, Meng W, Rosenfeld AM, Li EY, Wertheim G, Paessler M, Bagg A, Frank D, Tn K, Teachey DT, Lim MS, Luning Prak E, Fajgenbaum DC, Pillai V, Modern Pathology 35(4): 451-461, 2022, PMID:34686774
Hematopathologic Correlates of CAR T-Cell Therapy
Dolan JG, Paessler ME, Rheingold SR, Pillai V, Clinics in Laboratory Medicine 41(3): 325-339, 2021, PMID:34304768
Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis
Si S, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE, Journal of Clinical Immunology 41(6): 1213-1218, 2021, PMID:33761058
Combined Use of Emapalumab and Ruxolitinib in a Patient with Refractory Hemophagocytic Lymphohistiocytosis was Safe and Effective
Triebwasser MP, Barrett DM, Bassiri H, Bunin N, Elgarten C, Freedman J, Geera AS, Monos D, Lambert MP, Olson T, Seif AE, Paessler M, Petrosa W, Anne F Reilly, Romberg N, Sullivan KE, Quinn GZ, Behrens E, Teachey DT, Pediatric Blood and Cancer 68(7): , 2021, PMID:33754483
Evidence of Thrombotic Microangiopathy in Children with SARS-CoV-2 Across the Spectrum of Clinical Presentations
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT, Blood Advances 23(4): 6051-6063, 2020, PMID:33290544
