PEOPLE

Vinodh Pillai, MD, PhD

Associate Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
Perelman School of Medicine at the University of Pennsylvania

Contact InformationChildren's Hospital of Philadelphia
Department of Pathology and Laboratory Medicine
Philadelphia, PA, 19104
Fax: 215-590-1736

Research Expertise

CAR T cell therapy
Acute lymphoblastic leukemia
Castleman disease
Kikuchi-Fujimoto lymphadenitis
Single cell sequencing of pediatric lymphoma
Spatial transcriptomics

Clinical Expertise

Hematopoietic neoplasms
Pathology of CAR T cell therapy in B-ALL

Education

M.B.B.S. (Medicine and Surgery), Madras Medical College, 2002
Ph.D. (Biomedical sciences, Immunology), University of Texas Southwestern Medical Center , 2007

Specialty Certification

American Board of Pathology (Anatomic and Clinical Pathology), 2013
American Board of Pathology (Hematology/Hematopathology), 2014

Postgraduate Training

Compulsory Rotatory Residential Internship , Government General Hospital, Madras, India, 2001-2002
Post-Doctoral fellow of the National Multiple Sclerosis Society, Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, 2007-2009
Anatomic and Clinical Pathology Residency, Brigham and Women’s Hospital, Boston, MA, 2009-2013
Hematopathology , Brigham and Women’s Hospital, Dana Farber Cancer Institute and Boston
Children's Hospital Boston, MA, 2013-2014

Awards and Honors

Top 5 Poster Award in GSO Poster Competition, 2005
Eliot Goldings Award for the Best Graduate Student in Immunology, 2007
Graduate Student Organization (GSO) Travel Award, 2007
BWH Biomedical Research Institute Microgrant Award, 2012
Paul E. Strandjord Young Investigator Award from the Academy of Clinical Laboratory Physicians and Scientists, 2013
SIOP (International Society of Paediatric Oncology) Young Investigator Award, 2018
HTG EdgeSeq 2020 Autoimmune Panel Research Grant Award, 2020
Enid Gilbert Barness Prize - Society for Pediatric Pathology, 2022

Memberships and Professional Organizations

American Association of Immunologists, 2007 - 2009
Clinical Immunology Society, 2007 - 2009
United States and Canadian Academy of Pathology, 2011 - 2014
American Society for Clinical Pathology, 2012 - Present
Academy of Clinical Laboratory Physicians and Scientists, 2013 - 2015
Children's Oncology Group, 2015 - Present
International Clinical Cytometry Society, 2015 - present
Society for Hematopathology, 2015 - Present
Children's Oncology Group Young Investigator Mentorship Program, 2017 - Present
American Society for Clinical Oncology, 2018 - Present
College of American Pathologists, 2018 - Present
Perelman School of Medicine at the University of Pennsylvania, 2023 - 2023

Web Links


Selected Publications

Spatial and Single Cell Mapping of Castleman Disease Reveals Key Stromal Cell Types and Cytokine Pathways

Smith D, Eichinger A, Rech A, Wang J, Esteva E, Seyedian A, Yang X, Zhang M, Martinez D, Tan K, Luo M, Park C, Reizis B, Pillai V, bioRxiv, 2024, PMID:39314418

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CD5 Deletion Enhances the Antitumor Activity of Adoptive T Cell Therapies

Patel R, Ghilardi G, Zhang Y, Chiang YH, Xie W, Guruprasad P, Kim KH, Chun I, Angelos MG, Pajarillo R, Hong SJ, Lee YG, Shestova O, Shaw C, Cohen I, Gupta A, Vu T, Qian D, Yang S, Nimmagadda A, Snook AE, Siciliano N, Rotolo A, Inamdar A, Harris J, Ugwuanyi O, Wang M, Carturan A, Paruzzo L, Chen L, Ballard HJ, Blanchard T, Xu C, Abdel-Mohsen M, Gabunia K, Wysocka M, Linette GP, Carreno B, Barrett DM, Teachey DT, Posey AD, Powell Jr DJ, Sauter CT, Pileri S, Pillai V, Scholler J, Rook AH, Schuster SJ, Barta SK, Porazzi P, Ruella M, Sci Immunol 9(97): , 2024, PMID:39028827

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The Common Variable Immunodeficiency IgM Repertoire Narrowly Recognizes Erythrocyte and Platelet Glycans

Le Coz C, Trofa M, Yoon S, Tian T, Reid W, Cabrera EC, Knox A, Khanna C, Sullivan K, Heimall J, Takach P, Fadugba OO, Lawrence M, Jyonouchi1 S, Hakonarson H, Wells A, Handler S, Zur K, Pillai V, Gildersleeve JC, Romberg N, Journal of Allergy and Clinical Immunology, 2024, PMID:38692308

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Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Bandyopadhyay S, Duffy M, Jin Ahn K, Pang M, Smith D, Duncan G, Sussman J, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K, Cell, 2024, PMID:38559168

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Incidental Autopsy Finding of Retiform Hemangioendothelioma of the Spleen

Koga S, Tirado F, Pillai V, Lee FS, and Cooper K, Formosan Journal of Surgery, 2024

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Bandyopadhyay S, Duffy M, Ahn KJ, Pang M, Smith D, Duncan G, Sussman J, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen C, Thadi A, Chen C, Xu J, Reichart M, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K, 65th ASH Meeting and Exposition, 2023

Bone Marrow Fibrosis is Associated with Non-Response to CD19 CAR T-Cell Therapy in B-Acute Lymphoblastic Leukemia

Anil J, Alnemri A, Lytle A, Lockhart B, Anil AE, Baumgartner M, Gebre K, McFerran J, Grupp SA, Rheingold SR, Pillai V, Am J Hematol 98(12): 1888-1897, 2023, PMID:37718626

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Transdifferentiation of B-lymphoblastic Leukemia to Histiocytic Sarcoma After Immunotherapy

Fenu E, Margolskee E, Pillai V, American journal of hematology 98(8): E216-E218, 2023, PMID:37259821

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Alternative Splicing of Its 5' UTR Limits CD20 mRNA Translation and Enables Resistance to CD20-directed Immunotherapies

Ang Z, Paruzzo L, Hayer KE, Schmidt C, Diz MT, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Asnani M, Sainos PK, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A, Blood, 2023, PMID:37645778

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RAB27B Controls Palmitoylation Dependent NRAS Trafficking and Signaling in Leukemia

Ren J, Xing B, O’Keefe RA, Lv K, Wang R, Bauer K, Ghazaryan A, Burslem GM, Zhang J, O'Connell R, Pillai V, Hexner E, Philips M, Tong W, Journal of Clinical Investigation 133(12): e165510, 2023, PMID:37317963

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