Multiview Classification of Pediatric Medulloblastoma Refines Prognostic Stratification and Enables Imaging-Based Prediction of Risk

Adam Kraya, Komal Rathi, Anahita Fathi Kazerooni, Ammar Naqvi, Ariana Familiar, Yiran Guo, Qi Li, Varun Kesherwani, Angela Viaene, Mariarita Santi, Deep Gandhi, Yuankun Zhu, Xiaoyan Huang, Bo Zhang, Alex Sickler, Arastoo Vossough, Ali Nabavizadeh, Phillip Storm, Adam Resnick, and Brian Rood., The Innovation Oncology, 2026 SUBMITTED

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

Shuodan Zhang1,2, Omkar Singh1, Karen Dazelle1, Patrick J. Cimino1 , Zied Abdullaev1, Jing Wu1, Calixto-Hope Lucas2, Karisa Schreck2, Matthias Holdhoff2, Peter Pytel3, Vanessa Goodwill4, Rob Macaulay5, William McDonald6, Roberta Seidman7, Matthew Wood8, Krishna Bharani9 , Janna Neltner10, Hope Richard11, Koping Chang12, Linda Szymanski13, Stephen Yip14, Abir Mukherjee15, Osorio Lopes Abath Neto16, Suash Sharma16, Richard Green17, Daniel Brown18, Maria Gubbiotti19, Leomar Ballester19, Jennifer Eschbacher20, Matthew Smith-Cohn20, Murat Gokden21, Cristina Vincentelli22, William Yong23, Julieann Lee24, Cristopher Mount25, Ann Hill26, Sonika Dahiya27, Joseph Fulmer28, Michael Sun29, Keith Ligon29, Mariarita Santi30, Emily Ling-Lin Pai30, Gabrielle Yeaney31, Sanda Alexandrescu32, Ravi Raghavan33, Igor Fernandes34, Gerald Feliz Reis35, Daniel Brown36, Dario Caccamo37, Shilpa Rao38, Omar Butt39, Sara Stone40, Kyle Conway40, Maclean Nasrallah41, Christine Fuller42, Angus Toland43, Lukas Rimas44, David Cachia45, Erik Uhlmann46, Matthew McCord47, Jeffrey Helgager48, Karam Han48, Arie Perry49, Sandra Perez49, Elena Daoud50, Darby BeDell51, Hilary Highfield52, Peter Kobalka53, Stephen Nix54, Edjah Nduom55, Stewart Neill55, Mark Gilbert56, Nelli Lakis57, Adriana Fonseca58, Collete Shen59, Rebecca Yoda60, Lenore Monterroza61, Adam Cohen61, MD Al Amin62, Jian Campian62, Kenneth Aldape1,62, Neuro-Oncology, 2026 SUBMITTED

Integrated Molecular and Clinical Analysis of over 500 Pediatric Central Nervous System Tumors

Derek Wong, Fumin Lin, Cassie Kline, Jinhua Wu, Jeffrey Schubert, Jiani Chen, Netta Golenberg,Natali Naveh, Meha Patel, Feng Xu, Kajia Cao, Weixuan Fu,Elizabeth Denenberg, Elizabeth A. Fanning, Daniel Gallo, Kristin Zelley,Jean Belasco, Kavita Desai, Jessica B. Foster,Chelsea Kotch, Jane Minturn, Amish Shah, Shih-Shan Lang, Peter J. Madsen, Christine E. Hill-Kayser, Michael LaRiviere, Yimei Li, Gerald Wertheim, Minjie Luo, Lea F. Surrey, Yiming Zhong, Angela N. Viaene, Garrett M. Brodeur, Suzanne P. MacFarland, Mariarita Santi, Adam Resnick, Phillip B. Storm, Michael J. Fisher, Kristina A. Cole, Marilyn M. Li., Neuro-Oncology Pediatrics, 2026

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma"

Sussman JH, Oldridge DA, Yu W, Chen CH, Zellmer AM, Rong J, Parvaresh-Rizi A, Thadi A, Xu J, Bandyopadhyay S, Sun Y, Wu D, Emerson Hunter C, Brosius S, Ahn KJ, Baxter AE, Koptyra MP, Vanguri RS, McGrory S, Resnick AC, Storm PB, Amankulor NM, Santi M, Viaene AN, Zhang N, Raedt T, Cole K, Tan K., Cell reports medicine, 2026

Comprehensive Multi-Omics Insights into High-Grade Glioma in Children, Adolescents, and Young Adults

Pei Wang, Nicole Tignor, Mateusz Koptyra, Shrabanti Chowdhury, Francesca Petralia, Marina Gritsenko, Weiping Ma, Yuankun Zhu, Giacomo Marino, Xiaoyu Song, Simona Migliozzi, Jeffrey Whiteaker, Dmitry Rykunov, Yingwei Hu, Noshad Hosseini, Jo Lynne Rokita, Felipe da Veiga Leprevost, Komal Rathi, Lijun Chen, Yi-Ting Wang, Karl Weitz, Rosalie Chu, Ronald Moore, Azra Krek, Weijia Fu, Xuran Wang, Eden Deng, Chia-Feng Tsai, Tyler Sagendorf, Vladislav Petyuk, Tujin Shi, Thomas Fillmore, Rui Zhao, Matthew Monroe, Marius Dannappel, Paul Daniel, Lei Zhao, Richard Ivey, Travis Lorentzen, Tomer Yaron, Emily Huntsman, Jared Johnson, Nakib Nakib, Yan-chak Li, Mariarita Santi, Demetri Dupal, Jena Lilly, Adam Kraya, Joseph Dybas, Bo Zhang, Chuwei Zhong, Miguel Brown, Saksham Phul, Eric Wafula, Alvin Farrel, Zhuangzhuang Geng, Ryan Corbett, Ammar Naqvi, Daniel Miller, Jennifer Mason, Tatiana Patton, Stephanie McGrory, Shannon Robins, Allison Heath, Catherine Sullivan, Noel Coleman, Allison Morgan, Luciano Garofano, Boris Reva, Eric Schadt, Richard Smith, Mehdi Mesri, Ana I. Robles, Lewis Cantley, Li Ding, Karin Rodland, Bing Zhang, Alexey Nesvizhiskii, Antonio Iavarone, Marcin Cieslik, Joseph Ippolito, Phillip Storm, Joshua Rubin, Ron Firestein, Avi Ma'ayan, Hui Zhang, Amanda Paulovich, Tao Liu, Adam Resnick, Brian Rood, Pei Wang, Philadelphia Coalition for a Cure, Children's Brain Tumor Network, Clinical Proteomic Tumor Analysis Consortium, Cell Report Medicine, 2026

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

Natarajan SK, Lum J, Skeans JH, Nenwani M, Eyunni S, Mota M, Bayliss JM, Deogharkar A, Hamanishi ET, Pun M, Sweha SR, Hoffman S, Young E, Zhang Q, Mehta R, Animasahun O, Narayanan P, Sunil S, Parolia A, Sajjakulnukit P, Panwalkar P, Doherty R, Clausen M, Dang D, Hawes D, Yang F, Santi M, Judkins AR, Wilson Y, Vigil T, Franson A, Mortensen RM, Ozawa T, Griesinger A, Holland EC, Foreman NK, Michealraj KA, Agnihotri S, Taylor M, Gilbertson RJ, Koschmann C, Chinnaiyan AM, Lyssiotis CA, Nagrath D, Venneti S, Nature, 2026

Neuroepithelial Tumor Associated with AAV Integration After Intracisternal Magna Vector Delivery

Rebecca C. Ahrens-Nicklas, Chelsea Kotch, Aoife M. Roche, John K. Everett, Shantan Reddy, Mariarita Santi, Peter J. Madsen, Cristina Martos-Rus, Juliana C. Small, Sarah M. McCague, Benjamin J. Samelson-Jones, Marilyn Li, Can Ficicioglu, Raymond Wang, Frederic D. Bushman and Lindsey A. George., New England Journal of Medicine, 2026

Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence

Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M. Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. bioRxiv [Preprint]. 2025 Apr 9:2025.03.12.642624. doi: 10.1101/2025.03.12.642624. PMID: 40161803; PMCID: PMC11952471., Cancer Cell, 2026, PMID:40161803

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Disseminated pediatric low-grade glioma and hydrocephalus: a multinational consortium analysis of incidence and mortality

Lyons AT, Haizel-Cobbina J, Levine A, Bishay AE, Jew N, Li C, Patil P, Bennett J, Siddaway R, Yuditskiy R, Son A, Nakano Y, Patel PG, Ku M, Velázquez JE, Schniederjan MJ, Erker C, Cacciotti C, Santi M, Nelson EJ, Cheng S, Dunham C, Wilson B, Black K, van Landeghem FKH, Eisenstat DD, Guerreiro Stücklin AS, Weiser A, Larouche V, Giannakouros P, Fonseca A, Williamson L, Fernandes IL, Plant-Fox AS, Fleming AJ, Campbell S, Mushtaq N, Bukhari SI, Minhas K, Graham RT, Raskin S, Cvrlje FJ, Ludlow LE, Mulcahy Levy JM, Yamasaki K, Suzuki T, Ohka F, Arakawa Y, Ishihara T, Yamasaki F, Hansford JR, Luck A, Nasrallah MP, Toledano H, Masoud RM, Lassaletta A, Blasco-Santana L, Kilday JP, Talianski A, Davies HC, Johnston JM, Hale AT, Dirks PB, Rutka JT, Tabori U, Hawkins CE, Dewan MC, Journal of Neurosurgery: Pediatrics, 2025, PMID:41569919

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Integrated clinical and molecular landscape of disseminated pediatric low-grade glioma

Levine AB, Bennett J, Patil P, Burns I, Siddaway R, Li C, Haizel-Cobbina J, Rana M, Yuditskiy R, Son A, Nakano Y, Patel P, Ho IC, Ku M, Lyons AT, Velázquez Vega JE, Schniederjan MJ, Erker C, Cacciotti C, Santi M, Nelson EJ, Cheng S, Dunham C, Wilson B, Black K, Van Landeghem F, Nobre L, Eisenstat DD, Stücklin ASG, Weiser A, Larouche V, Giannakouros P, Fonseca A, Williamson L, Fernandes IL, Plant-Fox AS, Fleming A, Campbell S, Mushtaq N, Bukhari SI, Minhas K, Graham RT, Raskin S, Jadrijevic-Cvrlje F, Ludlow L, Macneil MV, Mulcahy-Levy JM, Demarsh S, Fukuoka K, Yamasaki K, Suzuki T, Ohka F, Kawamura A, Arakawa Y, Ishihara T, Yamasaki F, Hansford JR, Luck A, Nasrallah MP, Toledano H, Masoud RM, Lassaletta A, Blasco-Santana L, Kilday JP, Talianski A, Davies C, Johnston J, Hale AT, Dirks PB, Rutka JT, Dewan MC, Tabori U, Hawkins CE, Neuro-Oncology, 2025, PMID:41117845

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