Gerard D. Schellenberg, PhD

Professor of Pathology and Laboratory Medicine, Professor of Pathology and Laboratory Medicine in Genetics
Director, Penn Neurodegeneration Genomics Center
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
Room 609B, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104


Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Graduate Groups

Genomics and Computational Biology


B.S. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1973
Ph.D. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1978

Specialty Certification

Postgraduate Training

National Science Foundation Undergraduate, Summer Research Program, Department of Biochemistry, University of California at Riverside, CA, 1972-1972
National Science Foundation Undergraduate Research Fellowship, Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972-1972
Senior Research Fellow, Department of Medical Genetics, School of Medicine, RG-20, University of Washington, Seattle, WA, 1978-1979
Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington, Seattle, WA, 1979-1982
NIH Post Doctoral Fellowship, National Institute of Health, 1980-1982
Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington, Seattle, WA, 1982-1983

Awards and Honors

John Douglas French Foundation for Alzheimer's Disease, Investigator Award, 1986-1988
Potamkin Prize for Alzheimer's Disease Research
Potamkin Foundation and the American Academy of Neurology, 1994
Metropolitan Life Foundation, Awards for Medical Research, 1995
Alzheimer's Association Medical Honoree, for outstanding commitment to the research of Alzheimer's disease, 1996
National Institute on Aging, R37 Merit Award: Genomic analysis of Alzheimer’s disease, 2004

Memberships and Professional Organizations

American Society of Human Genetics, 1988 - present
Alzheimer's Association, 1990 - 1995
American Health Assistance Foundation, 1992 - 1994
Harvard Medical School Alzheimer's Disease Research Center, 1993 - 1997
University of Kansas Medical School Alzheimer's Disease Research Center, 1993 - 1995
NIH Neurology C Study Section, 1995 - 1998
Mount Sinai Alzheimer's Disease Research Center, 1998 - 1998
National Veterans Affairs Committee on Genetics Research, 1998 - 1998
NIH Brain Disorders and Clinical Neuroscience 3 Study Section, 1998 - 1999
Mayo Clinic Alzheimer's Disease Research Center, 2000 - 2004
NIH National Advisory Council for Human Genome Research, 2000 - 2008
National Alzheimer's Coordinating Center, 2001 - 2004
Virtual Research Institute on Aging: Nippon Boehringer-Ingelheim, 2001 - 2004
Indiana Alzheimer's Disease Center National Cell Repository, 2001 - present
American Society for Biochemistry and Molecular Biology, 2002 - Present
M.I.N.D. Institute Research Program,
University of California Davis, 2002 - 2005
Society of Progressive Supranuclear Palsy, 2003 - Present
Autism Genome Project, 2003 - Present
National Alliance for Autism Researsch, 2003 - Present
Alzheimer Research Consortium, 2003 - Present
Program Project "Presenilin Biology and the Mechanism of Alzheimer's Disease," Harvard Medical School, 2004 - 2007
Veteran's Affairs Dementia Prevention Study of Vitamin E and Mementine, 2005 - 2015
Resource Allocation Review Committee (RARC), Dominantly Inherited Alzheimer’s Disease (DIAN) Project, 2008 - present
Texas Alzheimer Research and Care Consortium, 2008 - present
Alzheimer’s Association, 2009 - 2010
Barcelona Think Tank Meeting on EU-US Collaborative Research on the Prevention of Dementia, 2009 - present
Peebler PSP Research Foundation, 2009 - present
7th International Conference on Frontotemporal Dementia, 2009 - 2010
NIA, 2010 - 2010
Alzheimer's Association, 2011 - present
International Genomics Alzheimer Project, 2011 - present
8th International Conference on Frontotemporal Dementias (FTD 2012), 2011 - 2012
United Kingdom Parkinson Disease Center, University College London, 2012 - present
NIA/NHGRI/NIH, 2012 - present
Member, The Dana Alliance for Brain Initiatives, 2013 - present
University of Miami Udall Center, 2013 - present
Oxford Parkinson’s Disease Centre, 2013 - present
Mayo Clinic Rochester Udall Center, 2013 - present
NIA/NHGRI/NIH, 2013 - present
NIA/NHGRI/NIH, 2014 - present

Selected Publications

Copy Number Variation Identification on 3,800 Alzheimer's Disease Whole Genome Sequencing Data from the Alzheimer's Disease Sequencing Project

Lee WP, Tucci AA, Conery M, Leung YY, Kuzma AB, Valladares O, Chou Y-F, Lu W, Wang L-S, Schellenberg GD, Tzeng J-Y, Front Genet 12(): 752390, 2021, PMID:34804120

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Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics

Sariya S, Felsky F, Reyes-Dumeyer D Lali, R, Lantigua RA, Vardarajan B, Jiménez-Velázquez IZ, Haines JL, Schellenberg GD, Pericak-Vance MA, Paré G, Mayeux R, Tosto G, Ann Neurol 90(3): 366-376, 2021, PMID:34038570

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Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease

Zhang X, Farrell JJ, Tong T, Hu J, Zhu C, Alzheimer’s Disease Sequencing Project; Wang L-S, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA, Alzheimers Dement, 2021, PMID:34152079

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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

de Rojas I, Moreno-Grau S, Tesí N, et al, Nat Commun 12(1): 3417, 2021, PMID:34099642

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Latent trait modeling of tau neuropathology in progressive supranuclear palsy

Kouri N, Murray ME, Reddy JS, et al, Acta Neuropathol 141(5): 667-680, 2021, PMID:33635380

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Gene-environment interactions in progressive supranuclear palsy

Litvan I, Proudfoot JA, Martin ER, Standaert D, Riley D, Hall D, Marras C, Bayram E, Dubinsky RM, Bordelon Y, Reich S, Shprecher D, Kluger B, Cunningham C, Schellenberg GD, Jankovic J, Front Neurol 12(): 664796, 2021, PMID:33897612

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In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics

Xu H, O'Reilly M, Gibbons GS, Changolkar L, McBride JD, Riddle DM, Zhang B, Stieber A, Nirschl J, Kim S-J, Hoxha K-H, Brunden KR, Schellenberg GD, Trojanowski JQ, Lee VM, Acta Neuropathol 141(2): 193-215, 2021, PMID:33385254

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Integration of GWAS and brain transcriptomic analyses in a multi-ethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance

Barral, Alzheimer Dement In Press(): , 2021