Gerard D. Schellenberg, PhD

Professor of Pathology and Laboratory Medicine, Professor of Pathology and Laboratory Medicine in Genetics
Director, Penn Neurodegeneration Genomics Center
University of Pennsylvania Perelman School of Medicine

Contact InformationDepartment of Pathology and Laboratory Medicine
University of Pennsylvania School of Medicine
Room 609B, Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104


Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Graduate Groups

Genomics and Computational Biology


B.S. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1973
Ph.D. (Biochemistry/minor: Cell Biology), University of California at Riverside, Riverside, CA, 1978

Specialty Certification

Postgraduate Training

National Science Foundation Undergraduate, Summer Research Program, Department of Biochemistry, University of California at Riverside, CA, 1972-1972
National Science Foundation Undergraduate Research Fellowship, Summer Research Program, Department of Biochemistry, University of California at Riverside, California, 1972-1972
Senior Research Fellow, Department of Medical Genetics, School of Medicine, RG-20, University of Washington, Seattle, WA, 1978-1979
Senior Research Fellow, Division of Neurology, Department of Medicine, University of Washington, Seattle, WA, 1979-1982
NIH Post Doctoral Fellowship, National Institute of Health, 1980-1982
Senior Research Fellow, Department of Genetics, School of Medicine, University of Washington, Seattle, WA, 1982-1983

Awards and Honors

John Douglas French Foundation for Alzheimer's Disease, Investigator Award, 1986-1988
Potamkin Prize for Alzheimer's Disease Research
Potamkin Foundation and the American Academy of Neurology, 1994
Metropolitan Life Foundation, Awards for Medical Research, 1995
Alzheimer's Association Medical Honoree, for outstanding commitment to the research of Alzheimer's disease, 1996
National Institute on Aging, R37 Merit Award: Genomic analysis of Alzheimer’s disease, 2004

Memberships and Professional Organizations

American Society of Human Genetics, 1988 - present
Alzheimer's Association, 1990 - 1995
American Health Assistance Foundation, 1992 - 1994
Harvard Medical School Alzheimer's Disease Research Center, 1993 - 1997
University of Kansas Medical School Alzheimer's Disease Research Center, 1993 - 1995
NIH Neurology C Study Section, 1995 - 1998
Mount Sinai Alzheimer's Disease Research Center, 1998 - 1998
NIH Brain Disorders and Clinical Neuroscience 3 Study Section, 1998 - 1999
National Veterans Affairs Committee on Genetics Research, 1998 - 1998
NIH National Advisory Council for Human Genome Research, 2000 - 2008
Mayo Clinic Alzheimer's Disease Research Center, 2000 - 2004
National Alzheimer's Coordinating Center, 2001 - 2004
Indiana Alzheimer's Disease Center National Cell Repository, 2001 - present
Virtual Research Institute on Aging: Nippon Boehringer-Ingelheim, 2001 - 2004
M.I.N.D. Institute Research Program,
University of California Davis, 2002 - 2005
American Society for Biochemistry and Molecular Biology, 2002 - Present
Autism Genome Project, 2003 - Present
National Alliance for Autism Researsch, 2003 - Present
Alzheimer Research Consortium, 2003 - Present
Society of Progressive Supranuclear Palsy, 2003 - Present
Program Project "Presenilin Biology and the Mechanism of Alzheimer's Disease," Harvard Medical School, 2004 - 2007
Veteran's Affairs Dementia Prevention Study of Vitamin E and Mementine, 2005 - 2015
Texas Alzheimer Research and Care Consortium, 2008 - present
Resource Allocation Review Committee (RARC), Dominantly Inherited Alzheimer’s Disease (DIAN) Project, 2008 - present
Peebler PSP Research Foundation, 2009 - present
Barcelona Think Tank Meeting on EU-US Collaborative Research on the Prevention of Dementia, 2009 - present
7th International Conference on Frontotemporal Dementia, 2009 - 2010
Alzheimer’s Association, 2009 - 2010
NIA, 2010 - 2010
International Genomics Alzheimer Project, 2011 - present
Alzheimer's Association, 2011 - present
8th International Conference on Frontotemporal Dementias (FTD 2012), 2011 - 2012
NIA/NHGRI/NIH, 2012 - present
United Kingdom Parkinson Disease Center, University College London, 2012 - present
Oxford Parkinson’s Disease Centre, 2013 - present
Member, The Dana Alliance for Brain Initiatives, 2013 - present
University of Miami Udall Center, 2013 - present
Mayo Clinic Rochester Udall Center, 2013 - present
NIA/NHGRI/NIH, 2013 - present
NIA/NHGRI/NIH, 2014 - present

Selected Publications

Common variants near ZIC1 and ZIC4 in autopsy-confirmed multiple system atrophy

Hopfner F, Tietz AK, Ruf VC, Ross OA, et al, Mov Disord 37(10): 2110-2121, 2022, PMID:35997131

Read article

Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease

Eissman JM, Dumitrescu L, Mahoney ER, et al, Brain 145(7): 2541-2554, 2022, PMID:35552371

Read article

A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer’s Disease in African Ancestry

Rajabli F, Beecham GW, Hendrie HC, et al, PLoS Genet 18(7): , 2022, PMID:35788729

Read article

New insights on the genetic etiology of Alzheimer’s and related dementias

Bellenguez C, Küçükali F, Jansen IE, et al, Nat Genet 54(4): 412-436, 2022, PMID:35379992

Read article

Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population

Godrich G, Martin ER, Schellenberg GD, Pericak-Vance MA, Cuccaro M, Scott WK, Kukull W, Montine T, Beecham GW, Alzheimers Dement 18(12): 2403-2412, 2022, PMID:35142102

Read article

Progranulin mutations in clinical and neuropathological Alzheimer's disease

Vardarajan BN, Reyes-Dumeyer D, Piriz AL, Lantigua RA, Medrano M, Rivera D, Jiménez-Velázquez IZ, Martin E, Pericak-Vance MA, Bush W, Farrer L, Haines JL, Wang LS, Leung YY, Schellenberg G, Kukull W, De Jager P, Bennett DA, Schneider JA; Alzheimer's Disease Sequencing Project, Mayeux R, Alzheimers Dement 18(12): 2458-2467, 2022, PMID:35258170

Read article

Alzheimer's Disease variant portal: a catalog of genetic findings for Alzheimer's Disease

Kuksa PP, Liu C-L, Fu W, Qu L, Zhao Y, Katanic Z, Kuzma AB, Ho P-C, Tzeng K-T, Valladares O, Chou S-Y, Naj AC, Schellenberg GD, Wang L-S, Leung YY, J Alzheimers Dis 86(1): 461-477, 2022, PMID:35068457

Read article

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimer’s Disease

Holstege H, Hulsman M, Charbonnier C, et al, Nat Genet 54(12): 1786-1794, 2022, PMID:36411364

Read article

Integration of GWAS and brain transcriptomic analyses in a multi-ethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance

Gao Y, Felsky D, Reyes-Dumeyer D, Sanjeev S, Rentería MA, Ma Y, Klein H, Cosentino S, De Jager P, Bennett DA, Brickman AM, Schellenberg GD, Mayeux R, Barral S, Alzheimers Dement 18(10): 1797-1811, 2022, PMID:34873813

Read article