PEOPLE

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Co-Director, Center for Neurodegenerative Disease Research
Director, Institute on Aging
Director, Alzheimer's Disease Core Center
Director, Penn Udall Center for Parkinson's Research
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Neurodegenerative Disease Research
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909

Email: TROJANOW@UPENN.EDU

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Graduate Groups

Neuroscience

Education

University of Vienna, Vienna, Austria, 1969
B.A. (German), King's College (1965-1967 & 1969-1970), 1970
Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974
Ph.D. (Neuroanatomy), Tufts University Graduate School of Arts and Sciences, 1976
M.D. Tufts University School of Medicine, 1976

Specialty Certification

American Board of Pathology, Anatomic Pathology and Neuropathology
National Board of Medical Examiners - No. 138521, 1981

Postgraduate Training

Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA, 1979-1980

Awards and Honors

Magna Cum Laude, King's College, 1970
Sandoz Award in Neurology, 1976
Wm. Dameshek Research Award, Tufts Univ. School of Medicine, 1976
Mead Johnson Excellence in Research Award, 1976
Roche Laboratories Neurosciences Research Award, 1976
N.I.N.C.D.S. National Research Service Award in Neuropathology, 1978-1979
N.I.N.C.D.S. Teacher Investigator Development Award (TIDA), NS-00762, 1983-1987
N.C.I. Method to Extend Research In Time (MERIT) Award, CA-36245-04-13, 1986-1995
M.A. Degree (Honoris Causa), University of Pennsylvania, 1987
Weil Award For Best Experimental Neuropathology Paper American Association of Neuropathologists, 1988
Elected Member, American Society of Clinical Investigation, 1991
Metropolitan Life Foundation Promising Investigator Award For Alzheimer's Disease Research, 1991
Established Investigator Award of the National Alliance for Research on Schizophrenia and Depression (NARSAD), 1994
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 1996
President, American Association of Neuropathology, 1997-1998
Pioneer Award for Alzheimer’s Disease Research of the Ronald and Nancy Reagan Research Institute, Alzheimer’s Association, 1998
Rita Hayworth Award for Medical Research in Alzheimer’s Disease, 1998
Potamkin Prize for Medical Research in Alzheimer’s Disease, 1998
Recognized by ISI as a an ISI "Highly Cited Researcher" (A list of the, 2000
Stanley Cohen Biomedical Research Award of the University of Pennsylvania School of Medicine, 2000
Member, Institute of Medicine of the National Academy of Sciences, Elected 2002, 2002
Irving Wright Award for Distinction of the American Federation for Aging Research, 2004-2004
Irving Wright Award of Distinction of the American Federation for Aging Research, 2004-2004
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Elected, Fellow of the College of Physicians of Philadelphia, 2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
F.E. Bennet Memorial Lecture of the American Neurological Association, 133rd Meeting, 2008-2008
Khalid Iqbal Lifetime Achievement Award presented at ICAD, 2009
The Wallace H. Coulter Lectureship Award (Endowed by the Wallace H. Coulter Foundation, Miami, FL) presented at AACC in Anaheim, CA, 2010
John Scott Award (establishd by John Scott in 1822 and given for inventions that have contributed in some outstanding way to the "comfort, welfare and happiness" of mankind by the City of Philadelphia since 1822), 2012
24th Annual Robert J. and Claire Pasarow Foundation Award in Neuropsychiatry Research, Los Angeles, CA, 2012
J. Allyn Taylor International Prize in Medicine, Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014, 2014
Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists, 13 June, 2015, 2015
The Mayo Clinic Irving S. Cooper Professorship, “New Understanding of Disease Progression and Therapy in Neurodegenerative Tauopathies”, Mayo Clinic, Rochester, MN, 21 August, 2017, 2017
Gordon Holmes Lecture of Association for British Neurology, Birmingham, England, 2018
Alzheimer’s Association Lifetime Achievement Award in Alzheimer’s Disease Research, AAIC Meeting, Chicago, IL, July 24, 2018

Memberships and Professional Organizations

The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, 2003 - Present
The Gerontological Society of America (GSA), Task Force on Research Committee, 2004 - 2007
8th International Conference on Progress in Alzheimer's and Parkinson's Disease, 2005 - 2007
Organizing Committee, 8th International Conference On Progress In
Alzheimer’s And Parkinson’s Disease, Salzburg, Austria, 2005 - 2007
Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, 2005 - Present
Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, 2005 - 2006
Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, 2007 - Present
Neuroscience Interest Group of the Institute of Medicine, 2007 - Present
Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, 2008 - 2011
National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, 2008 - Present
EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), 2008 - Present
Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, 2008 - Present
MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, 2008 - Present
NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, 2009 - Present
Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, 2010 - Present
National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, - Present
National Institute on Aging, - Present
The Institute for the Study of Aging, - Present
National Institute on Aging, - Present
University of Washington Alzheimer's Disease Research Center, - Present
American Academy of Neurology, - Present
Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, - Present
Institute on Aging, - Present
National Sleep Foundation, - Present
National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, - Present
National Cancer Institute, - Present
National Institutes of Health Pathology A Study Section, - Present
National Institutes of Child Health and Human Development, - Present
Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, - Present
Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, - Present
Alzheimer's Association, - Present
American Health Assistance Foundation Alzheimer's Disease Research Review Committee, - Present
National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, - Present
National Institutes of Neurologic Disorders and Stroke, - Present
American Brain Tumor Association, - Present
National Institute on Aging, - Present
National Institute on Aging, National Advisory Council on Aging (NACA), - Present
National Institute on Aging, Board of Scientific Councilors, - Present
Institute of Medicine Class of 2002, - Present
Society for Neuroscience, - Present
American Society for Cell Biology, - Present
American Association of Pathologists, - Present
American Association of Neuropathologists, - Present
American Society for Investigative Pathology, - Present
American Society for Clinical Investigators, - Present
American Academy of Neurology (Consultant, Potamkin Award Subcommittee), - Present
American Academy of Neurology (Consultant, Potamkin Award), - Present
Association of American Physicians, - Present
Killam Research Fellowship Program, The Canada Council, - Present
International Academy of Pathology, Abstract Review Board member, - Present
National Institutes of Health Neurology A Study Section, - Present
National Institutes of Health, - Present
National Institutes of Health Grant Study Section Reviewers Reserve, - Present
National Sleep Foundation, - Present
Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, - Present
Society for Neuroscience, - Present
Dystonia Medical Research Foundation, - Present
American Federation for Aging Research National Scientific Advisory Council, - Present
Amyotrophic Lateral Sclerosis Association Grant Review Committee, - Present
National Campaign to End Neurological Disorders (END)), - Present
University of Pittsburgh Alzheimer’s Disease Research Center, - Present
Elwyn Institute, Elwyn, PA, - Present
American Board of Pathology, - Present
Harvard Brain Tissue Resource Center, - Present

Web Links


Selected Publications

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau.

Narasimhan Sneha, Changolkar Lakshmi, Riddle Dawn M, Kats Alexandra, Stieber Anna, Weitzman Sarah A, Zhang Bin, Li Zhiyong, Roberson Erik D, Trojanowski John Q, Lee Virginia M Y, The Journal of experimental medicine 217(2): , 2020, PMID:31826239

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Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases.

Ramos Eliana Marisa, Dokuru Deepika Reddy, Van Berlo Victoria, Wojta Kevin, Wang Qing, Huang Alden Y, Deverasetty Sandeep, Qin Yue, van Blitterswijk Marka, Jackson Jazmyne, Appleby Brian, Bordelon Yvette, Brannelly Patrick, Brushaber Danielle E, Dickerson Bradford, Dickinson Susan, Domoto-Reilly Kimiko, Faber Kelley, Fields Julie, Fong Jamie, Foroud Tatiana, Forsberg Leah K, Gavrilova Ralitza, Ghoshal Nupur, Goldman Jill, Graff-Radford Jonathan, Graff-Radford Neill, Grant Ian, Grossman Murray, Heuer Hilary W, Hsiung Ging-Yuek R, Huey Edward, Irwin David, Kantarci Kejal, Karydas Anna, Kaufer Daniel, Kerwin Diana, Knopman David, Kornak John, Kramer Joel H, Kremers Walter, Kukull Walter, Litvan Irene, Ljubenkov Peter, Lungu Codrin, Mackenzie Ian, Mendez Mario F, Miller Bruce L, Onyike Chiadi, Pantelyat Alexander, Pearlman Rodney, Petrucelli Len, Potter Madeline, Rankin Katherine P, Rascovsky Katya, Roberson Erik D, Rogalski Emily, Shaw Leslie, Syrjanen Jeremy, Tartaglia Maria Carmela, Tatton Nadine, Taylor Joanne, Toga Arthur, Trojanowski John Q, Weintraub Sandra, Wong Bonnie, Wszolek Zbigniew, Rademakers Rosa, Boeve Brad F, Rosen Howard J, Boxer Adam L, Coppola Giovanni, Alzheimer's & dementia : the journal of the Alzheimer's Association 16(1): 118-130, 2020, PMID:31914217

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Utility of the global CDR plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.

Miyagawa Toji, Brushaber Danielle, Syrjanen Jeremy, Kremers Walter, Fields Julie, Forsberg Leah K, Heuer Hilary W, Knopman David, Kornak John, Boxer Adam, Rosen Howard J, Boeve Bradley F, Appleby Brian, Bordelon Yvette, Bove Jessica, Brannelly Patrick, Caso Christina, Coppola Giovanni, Dever Reilly, Dheel Christina, Dickerson Bradford, Dickinson Susan, Dominguez Sophia, Domoto-Reilly Kimiko, Faber Kelley, Ferrell Jessica, Fishman Ann, Fong Jamie, Foroud Tatiana, Gavrilova Ralitza, Gearhart Debra, Ghazanfari Behnaz, Ghoshal Nupur, Goldman Jill S, Graff-Radford Jonathan, Graff-Radford Neill, Grant Ian, Grossman Murray, Haley Dana, Hsiung Robin, Huey Edward, Irwin David, Jones David, Jones Lynne, Kantarci Kejal, Karydas Anna, Kaufer Daniel, Kerwin Diana, Kraft Ruth, Kramer Joel, Kukull Walter, Litvan Irene, Lucente Diane, Lungu Codrin, Mackenzie Ian, Maldonado Miranda, Manoochehri Masood, McGinnis Scott, McKinley Emily, Mendez Mario F, Miller Bruce, Multani Namita, Onyike Chiadi, Padmanabhan Jaya, Pantelyat Alexander, Pearlman Rodney, Petrucelli Leonard, Potter Madeline, Rademakers Rosa, Ramos Eliana M, Rankin Kate, Rascovsky Katya, Roberson Erik D, Rogalski Emily, Sengdy Pheth, Shaw Leslie, Tartaglia Maria C, Tatton Nadine, Taylor Joanne, Toga Arthur, Trojanowski John Q, Wang Ping, Weintraub Sandra, Wong Bonnie, Wszolek Zbigniew, Alzheimer's & dementia : the journal of the Alzheimer's Association 16(1): 106-117, 2020, PMID:31914218

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Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.

Roy Ethan R, Wang Baiping, Wan Ying-Wooi, Chiu Gabriel S, Cole Allysa L, Yin Zhuoran, Propson Nicholas E, Xu Yin, Jankowsky Joanna L, Liu Zhandong, Lee Virginia My, Trojanowski John Q, Ginsberg Stephen D, Butovsky Oleg, Zheng Hui, Cao Wei, The Journal of clinical investigation, 2020, PMID:31917687

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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.

Bassil Fares, Brown Hannah J, Pattabhiraman Shankar, Iwasyk Joe E, Maghames Chantal M, Meymand Emily S, Cox Timothy O, Riddle Dawn M, Zhang Bin, Trojanowski John Q, Lee Virginia M-Y, Neuron 105(2): 260-275.e6, 2020, PMID:31759806

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Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration.

Olney Nicholas T, Ong Elise, Goh Sheng-Yang M, Bajorek Lynn, Dever Reilly, Staffaroni Adam M, Cobigo Yann, Bock Meredith, Chiang Kevin, Ljubenkov Peter, Kornak John, Heuer Hilary W, Wang Ping, Rascovsky Katya, Wolf Amelia, Appleby Brian, Bove Jessica, Bordelon Yvette, Brannelly Patrick, Brushaber Danielle, Caso Christine, Coppola Giovanni, Dickerson Bradford C, Dickinson Susan, Domoto-Reilly Kimiko, Faber Kelly, Ferrall Jessica, Fields Julie, Fishman Ann, Fong Jamie, Foroud Tatiana, Forsberg Leah K, Gearhart Debra J, Ghazanfari Behnaz, Ghoshal Nupur, Goldman Jill, Graff-Radford Jonathan, Graff-Radford Neill R, Grant Ian, Grossman Murray, Haley Dana, Hsiung Gingyuek, Huey Edward D, Irwin David J, Jones David T, Kantarci Kejal, Karydas Anna M, Kaufer Daniel, Kerwin Diana, Knopman David S, Kramer Joel H, Kraft Ruth, Kremers Walter, Kukull Walter, Lapid Maria I, Litvan Irene, Mackenzie Ian R, Maldonado Miranda, Manoochehri Masood, McGinnis Scott M, McKinley Emily C, Mendez Mario F, Miller Bruce L, Onyike Chiadi, Pantelyat Alex, Pearlman Rodney, Petrucelli Len, Potter Madeleine, Rademakers Rosa, Ramos Eliana M, Rankin Katherine P, Roberson Erik D, Rogalski Emily, Sengdy Pheth, Shaw Leslie M, Syrjanen Jeremy, Tartaglia M Carmela, Tatton Nadine, Taylor Joanne, Toga Arthur, Trojanowski John Q, Weintraub Sandra, Wong Bonnie, Wszolek Zbigniew, Boxer Adam L, Boeve Brad F, Rosen Howard J, Alzheimer's & dementia : the journal of the Alzheimer's Association 16(1): 49-59, 2020, PMID:31784375

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Transmission of tauopathy strains is independent of their isoform composition.

He Zhuohao, McBride Jennifer D, Xu Hong, Changolkar Lakshmi, Kim Soo-Jung, Zhang Bin, Narasimhan Sneha, Gibbons Garrett S, Guo Jing L, Kozak Michael, Schellenberg Gerard D, Trojanowski John Q, Lee Virginia M-Y, Nature communications 11(1): 7, 2020, PMID:31911587

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Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.

Henderson Michael X, Covell Dustin J, Chung Charlotte Hiu-Yan, Pitkin Rose M, Sandler Raizel M, Decker Samantha C, Riddle Dawn M, Zhang Bin, Gathagan Ronald J, James Michael J, Trojanowski John Q, Brunden Kurt R, Lee Virginia M Y, Luk Kelvin C, Neurobiology of disease 136(): 104712, 2019, PMID:31837422

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Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.

Wheeler Jeanna M, McMillan Pamela, Strovas Timothy J, Liachko Nicole F, Amlie-Wolf Alexandre, Kow Rebecca L, Klein Ronald L, Szot Patricia, Robinson Linda, Guthrie Chris, Saxton Aleen, Kanaan Nicholas M, Raskind Murray, Peskind Elaine, Trojanowski John Q, Lee Virginia M Y, Wang Li-San, Keene C Dirk, Bird Thomas, Schellenberg Gerard D, Kraemer Brian, Science translational medicine 11(523): , 2019, PMID:31852801

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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.

Henderson Michael X, Sedor Samantha, McGeary Ian, Cornblath Eli J, Peng Chao, Riddle Dawn M, Li Howard L, Zhang Bin, Brown Hannah J, Olufemi Modupe F, Bassett Danielle S, Trojanowski John Q, Lee Virginia M Y, Neuron, 2019, PMID:31899072

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