PEOPLE

John Q. Trojanowski, MD, PhD

William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Co-Director, Center for Neurodegenerative Disease Research
Director, Institute on Aging
Director, Alzheimer's Disease Core Center
Director, Penn Udall Center for Parkinson's Research
University of Pennsylvania Perelman School of Medicine

Contact InformationCenter for Neurodegenerative Disease Research
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909

Email: TROJANOW@UPENN.EDU

Specialty Division

Neuropathology, Immunobiology and Experimental Pathology

Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Graduate Groups

Neuroscience

Education

University of Vienna, Vienna, Austria, 1969
B.A. (German), King's College (1965-1967 & 1969-1970), 1970
Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974
Ph.D. (Neuroanatomy), Tufts University Graduate School of Arts and Sciences, 1976
M.D. Tufts University School of Medicine, 1976

Specialty Certification

American Board of Pathology, Anatomic Pathology and Neuropathology
National Board of Medical Examiners - No. 138521, 1981

Postgraduate Training

Clinical Fellow in Medicine (Medical Intern, Mt. Auburn Hospital, Cambridge, MA), Harvard Medical School, 1976-1977
1977-79 Clinical Fellow in Pathology (Pathology and Neuropathology Resident, Massachusetts Gen. Hospital, Boston, MA) , Harvard Medical School, 1977-1979
Pathology and Neuropathology Resident, Hospital of the University of Pennsylvania, Philadelphia, PA, 1979-1980

Awards and Honors

Magna Cum Laude, King's College, 1970
Sandoz Award in Neurology, 1976
Wm. Dameshek Research Award, Tufts Univ. School of Medicine, 1976
Mead Johnson Excellence in Research Award, 1976
Roche Laboratories Neurosciences Research Award, 1976
N.I.N.C.D.S. National Research Service Award in Neuropathology, 1978-1979
N.I.N.C.D.S. Teacher Investigator Development Award (TIDA), NS-00762, 1983-1987
N.C.I. Method to Extend Research In Time (MERIT) Award, CA-36245-04-13, 1986-1995
M.A. Degree (Honoris Causa), University of Pennsylvania, 1987
Weil Award For Best Experimental Neuropathology Paper American Association of Neuropathologists, 1988
Metropolitan Life Foundation Promising Investigator Award For Alzheimer's Disease Research, 1991
Elected Member, American Society of Clinical Investigation, 1991
Established Investigator Award of the National Alliance for Research on Schizophrenia and Depression (NARSAD), 1994
Metropolitan Life Foundation Award for Medical Research in Alzheimer’s Disease, 1996
President, American Association of Neuropathology, 1997-1998
Potamkin Prize for Medical Research in Alzheimer’s Disease, 1998
Rita Hayworth Award for Medical Research in Alzheimer’s Disease, 1998
Pioneer Award for Alzheimer’s Disease Research of the Ronald and Nancy Reagan Research Institute, Alzheimer’s Association, 1998
Recognized by ISI as a an ISI "Highly Cited Researcher" (A list of the, 2000
Stanley Cohen Biomedical Research Award of the University of Pennsylvania School of Medicine, 2000
Member, Institute of Medicine of the National Academy of Sciences, Elected 2002, 2002
Irving Wright Award of Distinction of the American Federation for Aging Research, 2004-2004
Irving Wright Award for Distinction of the American Federation for Aging Research, 2004-2004
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Alzheimer Research Forum Award presented at SFN meeting, 2005-2005
Rous-Whipple Award from the American Society for Investigative Pathology, 2005-2005
Elected, Fellow of the College of Physicians of Philadelphia, 2005
F.E. Bennet Memorial Lecture of the American Neurological Association, 133rd Meeting, 2008-2008
Khalid Iqbal Lifetime Achievement Award presented at ICAD, 2009
The Wallace H. Coulter Lectureship Award (Endowed by the Wallace H. Coulter Foundation, Miami, FL) presented at AACC in Anaheim, CA, 2010
24th Annual Robert J. and Claire Pasarow Foundation Award in Neuropsychiatry Research, Los Angeles, CA, 2012
John Scott Award (establishd by John Scott in 1822 and given for inventions that have contributed in some outstanding way to the "comfort, welfare and happiness" of mankind by the City of Philadelphia since 1822), 2012
J. Allyn Taylor International Prize in Medicine, Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014, 2014
Award for Meritorious Contributions to Neuropathology from the American Association of Neuropathologists, 13 June, 2015, 2015
The Mayo Clinic Irving S. Cooper Professorship, “New Understanding of Disease Progression and Therapy in Neurodegenerative Tauopathies”, Mayo Clinic, Rochester, MN, 21 August, 2017, 2017
Alzheimer’s Association Lifetime Achievement Award in Alzheimer’s Disease Research, AAIC Meeting, Chicago, IL, July 24, 2018
Gordon Holmes Lecture of Association for British Neurology, Birmingham, England, 2018

Memberships and Professional Organizations

The Anne and Howard Gottlieb/Institute for the Study of Aging Award for Alzheimer’s Disease Drug Discovery, 2003 - Present
The Gerontological Society of America (GSA), Task Force on Research Committee, 2004 - 2007
Organizing Committee, 8th International Conference On Progress In
Alzheimer’s And Parkinson’s Disease, Salzburg, Austria, 2005 - 2007
8th International Conference on Progress in Alzheimer's and Parkinson's Disease, 2005 - 2007
Coins for Alzheimer’s Research Trust (CART), The CART Fund, in partnership with the American Federation for Aging Research, Grant Review, 2005 - Present
Member, Alzheimer 100 Scientific Advisory Board on the centennial of the presentation by Alois Alzheimer of the Auguste D. case in Tubingen on November 3, 1906, 2005 - 2006
Neuroscience Intrerest Group of the Institue of Medicine, Neuroscience,Behavior, Brain Function and Disorders, 2007 - Present
Neuroscience Interest Group of the Institute of Medicine, 2007 - Present
Alzheimer's Disease Neuroimaging Initiative Targeted Proteonomics Project Team, of the NIH Biomarkers Consortium and Foundation of the NIH, 2008 - Present
Member, NINDS Morris K. Udall Parkinson’s Disease Center Coordinating Committee, 2008 - 2011
EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), 2008 - Present
National Advisory Panel for the Surgery, Anesthesia, and Dementia Study, 2008 - Present
MetLife Foundation Awards for Medical Research in Alzheimer's Disease Advisory Committee, 2008 - Present
NIA Division of Aging Biology Review Subcommittee on the Nathan Shock Centers, 2009 - Present
Alliance for Aging Research Working Group on the Uses of Biomarkers in Alzheimer's Disease, 2010 - Present
National Institute on Aging, National Advisory Council on Aging (NACA), - Present
Elwyn Institute, Elwyn, PA, - Present
National Institutes on Aging, Neuroscience, Behavior and Sociology of Aging Review Committee (Sub-committee A) Study Section, - Present
National Cancer Institute, - Present
National Institutes of Health Pathology A Study Section, - Present
National Institutes of Child Health and Human Development, - Present
Alzheimer's Association, Ad Hoc Grant Reviewer; Medical and Scientific Advisory Board, - Present
Rush-Presbyterian-St. Luke's Medical Center, Alzheimer's Disease Center, Chicago IL, - Present
Alzheimer's Association, - Present
American Health Assistance Foundation Alzheimer's Disease Research Review Committee, - Present
National Instutitues on Aging Leadership and Excellence In Alzheimer's Disease (LEAD) Award, - Present
National Institutes of Neurologic Disorders and Stroke, - Present
National Institute on Aging, Board of Scientific Councilors, - Present
National Sleep Foundation, - Present
National Institutes of Health Grant Study Section Reviewers Reserve, - Present
National Institutes of Health, - Present
American Board of Pathology, - Present
Harvard Brain Tissue Resource Center, - Present
University of Pittsburgh Alzheimer’s Disease Research Center, - Present
National Campaign to End Neurological Disorders (END)), - Present
Amyotrophic Lateral Sclerosis Association Grant Review Committee, - Present
American Federation for Aging Research National Scientific Advisory Council, - Present
Dystonia Medical Research Foundation, - Present
Society for Neuroscience, - Present
Paul Beeson Physician Faculty Scholar in Aging Research Grant Review Committee, - Present
National Institutes of Neurologic Disorders and Stroke Parkinson’s Disease Center Grant Review Committee, - Present
National Institute on Aging, - Present
The Institute for the Study of Aging, - Present
National Institute on Aging, - Present
University of Washington Alzheimer's Disease Research Center, - Present
American Academy of Neurology, - Present
Alzheimer's Disease and Related Disorders Association of Greater Philadelphia, - Present
Institute on Aging, - Present
National Institute on Aging, - Present
American Brain Tumor Association, - Present
Institute of Medicine Class of 2002, - Present
National Institutes of Health Neurology A Study Section, - Present
International Academy of Pathology, Abstract Review Board member, - Present
Killam Research Fellowship Program, The Canada Council, - Present
Association of American Physicians, - Present
American Academy of Neurology (Consultant, Potamkin Award), - Present
American Academy of Neurology (Consultant, Potamkin Award Subcommittee), - Present
American Society for Clinical Investigators, - Present
American Society for Investigative Pathology, - Present
American Association of Neuropathologists, - Present
American Association of Pathologists, - Present
American Society for Cell Biology, - Present
Society for Neuroscience, - Present
National Sleep Foundation, - Present

Web Links


Selected Publications

The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates.

Riad A, Lengyel-Zhand Z, Zeng C, Weng CC, Lee VM, Trojanowski JQ, Mach RH., Mol Neurobiol, 2020

Defining and predicting transdiagnostic categories of neurodegenerative disease.

Cornblath EJ, Robinson JL, Irwin DJ, Lee EB, Lee VM, Trojanowski JQ, Bassett DS., Nat Biomed Eng., 2020

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation.

Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M; Alzheimer's Disease Neuroimaging Initiative (ADNI), Brendel M, Haass C, Franzmeier N., EMBO Mol Med. Online ahead of print., 2020

ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies.

Dai DL, Tropea TF, Robinson JL, Suh E, Hurtig H, Weintraub D, Van Deerlin V, Lee EB, Trojanowski JQ, Chen-Plotkin AS., Acta Neuropathol, 2020

Association of CSF Aβ, amyloid PET and cognition in cognitively unimpaired elderly adults.

Guo T, Shaw LM, Trojanowski JQ, Jagust WJ, Landau SM; Alzheimer's Disease Neuroimaging Initiative., Neurology, 2020

Distribution patterns of tau pathology in progressive supranuclear palsy.

Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM, Trojanowski JQ, Höglinger GU., Acta Neuropathol., 2020

Hallucinations and Development of Dementia in Parkinson's Disease.

Gryc W, Roberts KA, Zabetian CP, Weintraub D, Trojanowski JQ, Quinn JF, Hiller AL, Chung KA, Poston KL, Yang L, Hu SC, Edwards KL, Montine TJ, Cholerton BA., J Parkinsons Dis., 2020

Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau.

Kling MA, Goodenowe DB, Senanayake V, MahmoudianDehkordi S, Arnold M, Massaro TJ, Baillie R, Han X, Leung YY, Saykin AJ, Nho K, Kueider-Paisley A, Tenenbaum JD, Wang LS, Shaw LM, Trojanowski JQ, Kaddurah-Daouk RF; Alzheimer's Disease Metabolomics Consortium (ADMC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI)., Alzheimers Dement., 2020

ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration.

Cousins KAQ, Irwin DJ, Wolk DA, Lee EB, Shaw LMJ, Trojanowski JQ, Da Re F, Gibbons GS, Grossman M, Phillips JS., Brain, 2020, PMID:32666090

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Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis.

Gao Y, Wang T, Yu X; International FTD-Genomics Consortium (IFGC), Zhao H, Zeng P., Sci Rep., 2020

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