New insights into the genetic etiology of Alzheimer's disease and related dementias.

Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, (716 co-authors), Wang LS, Wang R, Weinhold L, Wiltfang J, Windle G, Woods B, Yannakoulia M, Zare H, Zhao Y, Zhang X, Zhu C, Zulaica M; EADB; GR@ACE; DEGESCO; EADI; GERAD; Demgene; FinnGen; ADGC; CHARGE, Farrer LA, Psaty BM, Ghanbari M, Raj T, Sachdev P, Mather K, Jessen F, Ikram MA, de Mendonça A, Hort J, Tsolaki M, Pericak-Vance MA, Amouyel P, Williams J, Frikke-Schmidt R, Clarimon J, Deleuze JF, Rossi G, Seshadri S, Andreassen OA, Ingelsson M, Hiltunen M, Sleegers K, Schellenberg GD, van Duijn CM, Sims R, van der Flier WM, Ruiz A, Ramirez A, Lambert JC., Nature Genetics 54(4): 412-436, 2022, PMID:35379992

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Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

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INFERNO: INFERring the molecular mechanisms of NOncoding genetic variants

Amlie-Wolf, Alexandre; Tang, Mitchell; Mlynarski, Elizabeth; Kuksa, Pavel P; Valladares, Otto; Katanic, Zivadin; Tsuang, Debby; Brown, Christopher; Schellenberg, Gerard D.; Wang, Li-San, Nucleic Acids Research 46(17): 8740-8753, 2018

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

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Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States.

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High-throughput identification of long-range regulatory elements and their target promoters in the human genome.

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

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