Yongping Wang, MD, PhD
Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact InformationStem Cell Lab, 5NW60 Main Building
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759
Email: wangy2@email.chop.edu
Specialty Division
Cancer and Immunobiology
Research Expertise
RNAi, library screening, stem cell, erythropoiesis
Clinical Expertise
cGMP cellular therapy, stem cell, bone marrow transplant, mesenchymal stromal cell (MSC), chimeric antigen receptor T cells (CARTs)
Education
B.S. (Molecular Biophysics and Biochemistry; Economics), Yale, 1995
M.D, Ph.D. (Medicine; Pharmacology), Dartmouth Medical School, 2003
Specialty Certification
Clinical Pathology and Transfusion Medicine, 2007
Clinical Pathology and Transfusion Medicine, 2017
AABB Certification in Advanced Biotherapies, 2022
Postgraduate Training
Resident, Clinical Pathology, Hospital of University of Pennsylvania, 2003-2008
Fellow, Transfusion Medicine, Hospital of University of Pennsylvania, 2006-2007
Certificate, Clinical Pathology and Transfusion Medicine, University of Pennsylvania, 2007-2007
Post-doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2008-2009
Awards and Honors
Summer Undergraduate Research Fellowship, California Institute of Technology, 1994
Max Kade Foundation Fellowship, Yale University and Universtität Heidelberg, 1994
Honors in Economics, Yale University, 1995
Honors in Molecular Biophysics and Biochemistry, Yale University, 1995
Magna Cum Laude, Yale University, 1995
Howard Hughes Medical Institute Predoctoral Fellowship, Howard Hughes Medical Institute, 1996-2000
SmithKlein Beecham Student Award, New England Pharmacologists 27th Annual Meeting, 1998
Honor Student, American Academy of Achievements, 2000
The Leonard Berwick Residency Teaching Award, Deptartment of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2006
University of Pennsylvania Medical School, Basic Science Teaching Award, 2006
The William Pepper Resident Award, Dept. of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2007
The Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 43rd Annual Meeting Philadelphia, Pennsylvania, 2008
Memberships and Professional Organizations
AABB - Association for the Advancement of Blood and Biotherapies, 2007 - present
International Society for Cell and Gene Therapy, 2011 - present
Web Links
Selected Publications
The Safety of Familial Virus Specific Cytotoxic T-Lymphocytes for the Treatment of Refractory Viral Infection after Allogeneic Hematopoietic Stem Cell Transplantation, and Solid Organ Transplantation
Edo Schaefer, Allyson Flower, Janet Ayello, Yaya Chu, Carmella van De Ven, Lauren Harrison, Erin Morris, Yongping Wang, MD, Shalini Shenoy, Dean Lee, MD, Rolla Abu-Arja, Bryon D. Johnson, Michael R. Verneris, Christopher C. Dvorak, Julia Chu, Kenneth R. Cooke, Julie Talano, Nancy Bunin, Mitchell S. Cairo, 56th Congress of the International Society of Paediatric Oncology, Honolulu, HI, 2024
Treatment of Refractory Cytomegalovirus (CMV) Infections using CMV-specific Cytotoxic T-lymphocytes (CTLs) in Children, Adolescents and Young Adults (CAYA) Post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) or Solid Organ Transplant (SOT)
Edo Schaefer, MD, Allyson Flower, MD, Janet Ayello, MS, MT, Yaya Chu, PhD, Carmella van De Ven, MS, Elizabeth Mintzer, Lauren Harrison, RN, MSN, Erin Morris, RN, Yongping Wang, MD, PhD, Shalini Shenoy, MD, MBBS, Dean Lee, MD, PHD, Rolla Abu-Arja, MD, Bryon D. Johnson, PhD, Michael R. Verneris, MD, Christopher C. Dvorak, MD, Julia Chu, MD, MPH, Kenneth R. Cooke, MD, Julie Talano, MD, Nancy Bunin, MD, Mitchell S. Cairo, MD, Pediatric Transplantation and Cellular Therapy Consortium Annual meeting, Seattle, WA, 2024
Adenoviral Cellular Therapy with Adenovirus (ADV)-specific Cytotoxic T-lymphocytes (CTLs) for Resistant Infections in Children, Adolescent, and Young Adult (CAYA) Patients Following Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT): A Promising Approach
Edo Schaefer, MD Christine Vu, DO Allyson Flower, MD Janet Ayello, MS, MT(ASCP) Yaya Chu, PhD Carmella van de Ven, MA Elizabeth Mintzer Lauren Harrison, RN, MSN Erin Morris, RN, BSN Yongping Wang, MD, PhD Shalini Shenoy, MD Dean Anthony Lee, MD, PhD Rolla Abu-Arja, MD Bryon D Johnson, PhD Michael R. Verneris, MD Christopher C. Dvorak, MD Julia Chu, MD Kenneth R. Cooke, MD Julie A Talano, MD Nancy J. Bunin, MD Mitchell S. Cairo, MD, Transplantation and Cellular Therapy 30(2): S432, 2024
Unrelated and Haploidentical Peripheral Stem Cell Transplant with TCRαβ/CD19 Depletion for the Treatment of Pediatric Patients with Inborn Errors of Immunity
Susan E. McClory, MD, PhD Caitlin W. Elgarten, MD, MSCE Kaitlyn N Quijano Anne Wohlschlaeger, MSN, CRNP Mrs. Patricia Hankins, BSN, RN Lei Wang, PhD Yongping Wang, MD, PhD Stephan Kadauke, MD, PhD Dimitri Monos, PhD Timothy S. Olson, MD, PhD Stephan A. Grupp, MD, PhD Elisa Ochfeld Jennifer R. Heimall, MD Nancy J. Bunin, MD, Transplantation and Cellular Therapy 30(2): S68, 2024
Outcomes of Unrelated Partial T Cell Depleted Stem Cell Transplantation for Patients with Hemoglobinopathies
Nora M. Gibson, MD Caitlin W. Elgarten, MD, MSCE Joseph H. Oved, M.D. M.A. Lisa Wray, MD Jason L. Freedman, MD, MSCE Yongping Wang, MD, PhD Stephan Kadauke, MD, PhD Patricia Hankins, BSN, RN, CCRC Peter Nicholas Elizabeth Worster, CRNP Janet L. Kwiatkowski, MD, MSCE Stephan A. Grupp, MD, PhD Nancy J. Bunin, MD Timothy S. Olson, MD, PhD, Transplantation and Cellular Therapy 30(2): S301, 2024
Pilot study of unrelated donor (URD) peripheral stem cell transplant (PSCT) with CD45RA depleted addback following TCRab/CD19 depletion in pediatric patients with hematologic malignancies
Caitlin W. Elgarten, MD, MSCE Stephanie Heidemann, MD Jason L. Freedman, MD, MSCE Stephan A. Grupp, MD, PhD Patricia Hankins, BSN, RN, CCRC Stephan Kadauke, MD, PhD Yimei Li, PhD Barbara McGlynn, BSN, RN Timothy S. Olson, MD, PhD Yongping Wang, MD, PhD Lisa Wray, MD Lei Wang, PhD Alix E. Seif, MD, MPH Nancy J. Bunin, MD, Transplantation and Cellular Therapy 30(2): S9, 2024
A Machine Learning Model That Incorporates CD45 Surface Expression Predicts Hematopoietic Progenitor Cell Recovery After Freeze-thaw
Arwa Z. Al-Riyami, Elena Maryamchik, Richard S. Hanna, Amir Reza Pashmineh Azar, Xingwu Zheng, Shilpa Choudhari, Colleen Finn, Nicholas Giacobbe, Rene Machietto, Robert Rieser, Farzaneh Ghasemi Tahrir, Xiaoyong Zhang, Stephan Kadauke, Yongping Wang, Cytotherapy 25(10): 1048-1056, 2023
Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor
Rene Machietto, Nicholas Giacobbe, Jessica Perazzelli, Ted J. Hofmann, Allison Barz Leahy, Stephan A. Grupp, Yongping Wang, Stephan Kadauke, J Vis Exp 198(): doi: 10.3791/65488 online only, 2023
In vivo modification of hematopoietic stem cells by targeted lipid nanoparticles delivering mRNA
Laura Breda, Tyler E. Papp, Michael P. Triebwasser, Amir Yadegari, Megan T. Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A. Grupp, Stella Chou, Houping Ni, Barbara L. Mui, Ying K. Tam, Drew Weissman, Stefano Rivella and Hamideh Parhiz, Science 381(6656): 436-443, 2023
Manufacture and Characterization of GMP-Compliant SARS-COV-2 Cytotoxic T Lymphocytes
Yaya Chu, Jordan Milner, Margaret Lamb, Elena Maryamchik, Olivia Rigot, Janet Ayello, Lauren Harrison, Rosemarie Shaw, Gregory K. Behbehani6, Elaine R. Mardis, Katherine Miller, Lakshmi Prakruthi Rao Venkata, Hsiaochi Chang, Dean Lee, Elana Rosenthal, Stephan Kadauke, Nancy Bunin, Julie-An Talano, Bryon Johnson, Yongping Wang*, and Mitchell S. Cairo* (*co-senior author), The Journal of Infectious Diseases 227(6): 788-799, 2023
