Yongping Wang, MD, PhD
Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact InformationStem Cell Lab, 5NW60 Main Building
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759
Email: wangy2@email.chop.edu
Specialty Division
Cancer and Immunobiology
Research Expertise
RNAi, library screening, stem cell, erythropoiesis
Clinical Expertise
cGMP cellular therapy, stem cell, bone marrow transplant, hemoglobinopathy gene therapy, chimeric antigen receptor T cells (CARTs)
Education
B.S. (Molecular Biophysics and Biochemistry; Economics), Yale University, 1995
M.D, Ph.D. (Medicine; Pharmacology), Dartmouth Medical School, 2003
Specialty Certification
Clinical Pathology and Transfusion Medicine, 2007
Clinical Pathology and Transfusion Medicine, 2017
AABB Certified Advanced Biotherapies Professional CABP(H), 2022
Postgraduate Training
Resident, Clinical Pathology, Hospital of University of Pennsylvania, 2003-2008
Fellow, Transfusion Medicine, Hospital of University of Pennsylvania, 2006-2007
Certificate, Clinical Pathology and Transfusion Medicine, University of Pennsylvania, 2007-2007
Post-doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2008-2009
Awards and Honors
Max Kade Foundation Fellowship, Yale University and Universtität Heidelberg, 1994
Summer Undergraduate Research Fellowship, California Institute of Technology, 1994
Magna Cum Laude, Yale University, 1995
Honors in Economics, Yale University, 1995
Honors in Molecular Biophysics and Biochemistry, Yale University, 1995
Howard Hughes Medical Institute Predoctoral Fellowship, Howard Hughes Medical Institute, 1996-2000
SmithKlein Beecham Student Award, New England Pharmacologists 27th Annual Meeting, 1998
Honor Student, American Academy of Achievements, 2000
The Leonard Berwick Residency Teaching Award, Deptartment of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2006
University of Pennsylvania Medical School, Basic Science Teaching Award, 2006
The William Pepper Resident Award, Dept. of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2007
The Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 43rd Annual Meeting Philadelphia, Pennsylvania, 2008
Memberships and Professional Organizations
AABB - Association for the Advancement of Blood and Biotherapies, 2007 - present
International Society for Cell and Gene Therapy, 2011 - present
Web Links
Selected Publications
Ex Vivo HSC Base Editing Using LNP-Delivered ABE8e for Fetal Hemoglobin Induction in Sickle Cell Disease
Sarah Cotteta, Omar Banda, Yongping Wang, Mohamad-Gabriel Alameh, Stephan Grupp, Eugene Khandros, Stephan Kadauke, International Society for Cell and Gene Therapy annual meeting, Dublin, Ireland, 2026
Scalable, Cost-Effective Point-of-Care Manufacture of huCART19 Cells with Excellent Clinical Outcomes in Pediatric B-ALL
Allison Barz Leahy, Jennifer Brogdon, Lucy E. Cain, Amanda DiNofia, Joseph A. Fraietta, Nicholas Giacobbe, Richard Hanna, Kathleen Kane, Yimei Li, Shannon Maude, Regina Myers, Ezra Porter, Anna Sparrow, Nancy Shapiro, Melissa Varghese, Yongping Wang, Stephan Kadauke, Stephan A. Grupp, International Society for Cell and Gene Therapy annual meeting, Dublin, Ireland, 2026
Improved Hematopoietic Stem Cell Mobilization for Gene Therapy of Hemoglobinopathies Using Single Agent Motixafortide
Stephan A Grupp, Michael S Grimley, Timothy Driscoll, Kris Michael Mahadeo, Alexis Leonard, Yongping Wang, Helen Phillips, David Justus, Leslie E Lehmann, Erica Esrick, Sarah Nikiforow, Julie Kanter, Matthew Hsieh, John F Tisdale, Akshay Sharma, Zachary D Crees, John Manis, Transplantation and Cellular Therapy 32(2S): S18, 2026
Genomic and Immunomic Characterization, Safety and Efficacy of Related Donor-Derived Cytotoxic T-Lymphocytes (CTLs) in Immunocompromised Recipients with Medically Refractory Adv and CMV Infection: On Behalf of the Viral CTL Consortium (VIRCTLC)
Mitchell S. Cairo, Dean A Dean Lee, Laura Vella, Yanling Liao, Edo Schaefer, Allyson Flower, Yimei Li, Morgan Anderson-Crannage, Carmella van de Ven, Lauren Harrison, Erin Morris, Yongping Wang, Monica Manglani, Yi Qi, Jonathan Tedesco, Shalini Shenoy, Christopher C. Dvorak, Kenneth R. Cooke, Michael R. Verneris, Neena Kapoor, Julie A Talano, Transplantation and Cellular Therapy 32(2S): S93, 2026
Training in Cell and Gene Therapy Manufacturing: Unmet Needs and Arguments for Graduate Medical Education
Wang Y, McKenna D, Spitzer T, Brunker P, Nedelcu E, Fesnak A, Celluzzi C, DiGuardo M, Jacob EK, Transfusion 66(1): 259-65, 2026
Alternative Donor Peripheral Stem Cell Transplantation With TCRαβ/CD19 Depletion For Pediatric Patients With Bone Marrow Failure
Caitlin W. Elgarten, Joseph H. Oved, Lisa Wray, Kimberly Venella, Peter Nicholas, Stephan Kadauke, Yongping Wang, Stephan Grupp, Timothy S. Olson, EJC Paediatric Oncology 6(Supplement 1): , 2025
Toward ‘n of one’ gene therapies: Scalable ex vivo adenine base editing via lipid nanoparticles in a sickle cell disease model
Sarah Cotteta, Omar Banda, Friederike Herbst-Nowrouzi, Brooklyn McDonald, Yongping Wang, Mohamad-Gabriel Alameh, Frederic Bushman, Stephan Grupp, Eugene Khandros, Stephan Kadauke, Blood 146(Supplement 1): , 2025
Outcomes of Unrelated Donor Stem Cell Transplantation with Partial T Cell Depletion for Pediatric Patients with Hemoglobinopathies
Gibson NM, Elgarten CW, Oved JH, Wray L, Freedman J, Khandros E, Worster E, Nicholas P, Kadauke S, Wang Y, Grupp S, Kwiatkowski JL, Olson TS, Transplant Cell Ther 31(10): 828.e1-e14, 2025
Final results of the safety and efficacy of related donor-derived CMV and Adenovirus (ADV) Cytotoxic T-Lymphocytes in children and adolescents with medically refractory infection.
Mitchell S. Cairo, Julie-An Talano, Allyson Flower, Edo Schaefer, Yongping Wang, Yimei Li, Janet Ayello, Lauren Harrison, Yaya Chu, Yanling Liao, Kenneth Cooke, Michael Verneris, Julie Chu, Christopher Dvorak, Shalini Shenoy, Scott Goebel, Neena Kapoor, Rolla Abu-Anja, Caitlin Elgarten, Angelina Jacob, Laura Vella, Nancy Bunin, and Dean Lee, 57th Congress of the International Society of Paediatric Oncology, Amsterdam, Netherlands, 2025
Challenging immunophenotyping of patients with sickle cell disease adversely affects gene therapy product manufacturing – case reports
Nora M. Gibson, Arwa Z. Al-Riyami, Alexis Peedin, Stephan Kadauke, Stephan Grupp, Timothy S. Olson, Yongping Wang, International Society for Cell and Gene Therapy Annual Meeting, New Orleans, LA, 2025
