Yongping Wang, MD, PhD
Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact InformationStem Cell Lab, 5NW60 Main Building
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759
Email: wangy2@email.chop.edu
Specialty Division
Cancer and Immunobiology
Research Expertise
RNAi, library screening, stem cell, erythropoiesis
Clinical Expertise
cGMP cellular therapy, stem cell, bone marrow transplant, mesenchymal stromal cell (MSC), chimeric antigen receptor T cells (CARTs)
Education
B.S. (Molecular Biophysics and Biochemistry; Economics), Yale, 1995
M.D, Ph.D. (Medicine; Pharmacology), Dartmouth Medical School, 2003
Specialty Certification
Clinical Pathology and Transfusion Medicine, 2007
Clinical Pathology and Transfusion Medicine, 2017
Postgraduate Training
Resident, Clinical Pathology, Hospital of University of Pennsylvania, 2003-2008
Fellow, Transfusion Medicine, Hospital of University of Pennsylvania, 2006-2007
Certificate, Clinical Pathology and Transfusion Medicine, University of Pennsylvania, 2007-2007
Post-doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2008-2009
Awards and Honors
Max Kade Foundation Fellowship, Yale University and Universtität Heidelberg, 1994
Summer Undergraduate Research Fellowship, California Institute of Technology, 1994
Honors in Molecular Biophysics and Biochemistry, Yale University, 1995
Magna Cum Laude, Yale University, 1995
Honors in Economics, Yale University, 1995
Howard Hughes Medical Institute Predoctoral Fellowship, Howard Hughes Medical Institute, 1996-2000
SmithKlein Beecham Student Award, New England Pharmacologists 27th Annual Meeting, 1998
Honor Student, American Academy of Achievements, 2000
University of Pennsylvania Medical School, Basic Science Teaching Award, 2006
The Leonard Berwick Residency Teaching Award, Deptartment of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2006
The William Pepper Resident Award, Dept. of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2007
The Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 43rd Annual Meeting Philadelphia, Pennsylvania, 2008
Memberships and Professional Organizations
AABB - Association for the Advancement of Blood and Biotherapies, 2007 - present
International Society for Cell and Gene Therapy, 2011 - present
AABB Cellular Therapy Section, Committee on Novel Therapies and CT Product Development, 2014 - Present
Web Links
Selected Publications
Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor
Rene Machietto, Nicholas Giacobbe, Jessica Perazzelli, Ted J. Hofmann, Allison Barz Leahy, Stephan A. Grupp, Yongping Wang, Stephan Kadauke, J Vis Exp, 2023
In vivo modification of hematopoietic stem cells by targeted lipid nanoparticles delivering mRNA
Laura Breda, Tyler E. Papp, Michael P. Triebwasser, Amir Yadegari, Megan T. Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A. Grupp, Stella Chou, Houping Ni, Barbara L. Mui, Ying K. Tam, Drew Weissman, Stefano Rivella and Hamideh Parhiz, Science 381(6656): 436-443, 2023
A Machine Learning Model That Incorporates CD45 Surface Expression Predicts Hematopoietic Progenitor Cell Recovery After Freeze-thaw
Arwa Z. Al-Riyami, Elena Maryamchik, Richard S. Hanna, Amir Reza Pashmineh Azar, Xingwu Zheng, Shilpa Choudhari, Colleen Finn, Nicholas Giacobbe, Rene Machietto, Robert Rieser, Farzaneh Ghasemi Tahrir, Xiaoyong Zhang, Stephan Kadauke, Yongping Wang, Cytotherapy, 2023
Infusing Collaboration: Stem Cell Infusion Day Procedures
Emily Roth, Danielle Reahm, Anna D'Aprile, Jason L Freedman, Stephan A. Grupp, and Yongping Wang, American Society of Transplantation & Cellular Therapy annual meeting. Orlando, FL., 2023
Manufacture and Characterization of GMP-Compliant SARS-COV-2 Cytotoxic T Lymphocytes
Yaya Chu, Jordan Milner, Margaret Lamb, Elena Maryamchik, Olivia Rigot, Janet Ayello, Lauren Harrison, Rosemarie Shaw, Gregory K. Behbehani6, Elaine R. Mardis, Katherine Miller, Lakshmi Prakruthi Rao Venkata, Hsiaochi Chang, Dean Lee, Elana Rosenthal, Stephan Kadauke, Nancy Bunin, Julie-An Talano, Bryon Johnson, Yongping Wang*, and Mitchell S. Cairo* (*co-senior author), The Journal of Infectious Diseases, 2022
Treating Children, Adolescents, and Young Adults (CAYA) with Refractory Viral Infections in Primary Immunodeficiencies (PID), or Post Solid Organ Transplant (SOT) or Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) with Virus Specific T- Lymphocytes (vCTLs)
Jordan Milner, Julie-An Talano, Lauren Harrison, Janet Ayello, Allyson Flower, Yaya Chu, Olivia Rigot, Bryon D Johnson, Yimei Li, Dean Anthony Lee, Rolla Abu-Arja, Julia Chu, Christopher C. Dvorak, Lynn C. O'Donnell, Yongping Wang, Nancy J. Bunin, and Mitch S. Cairo, Pediatric Transplantation & cellular Therapy Consortium annual meeting, 2022
Unrelated donor α/β T-cell and B-cell-depleted HSCT for the treatment of pediatric acute leukemia
Allison Barz Leahy, Yimei Li, Julie-An Talano, Caitlin W. Elgarten, Alix E. Seif, Yongping Wang, Bryon Johnson, Dimitri S. Monos, Stephan Kadauke, Timothy S. Olson, Jason Freedman, Lisa Wray, Stephan A. Grupp, Nancy Bunin, Blood Advances 6(4): 1175-1185, 2022
Ex Vivo T-Cell Receptor αβ +/CD19 +depletion of Peripheral Stem Cell Grafts for Pediatric Patients with Bone Marrow Failure (BMF) Undergoing Unrelated Donor Transplantation
Joseph H Oved, Caitlin W Elgarten, Yongping Wang, Stephan Kadauke, Dimitri S. Monos, David M. Barrett, Stephan A. Grupp, Nancy Bunin, Timothy S. Olson, Blood 138 Supp(): 171, 2021
Manufacture and Immunological Characterization of GMP-compliant functional SARS-COV-2 cytotoxic T lymphocytes (CTLs) utilizing the CliniMACS Cytokine Capture System
Yaya Chu, Jordan Milner, Margaret Lamb, Elena Maryamchik, Olivia Rigot, Janet Ayello, Lauren Harrison, Rosemarie Shaw, Greg K. Behbehani, Elaine R. Mardis, Katherine E Miller, Lakshmi Prakruthi Rao Venkata, Hsiaochi Chang, Dean Anthony Lee, Elana Y. Rosenthal, Stephan Kadauke, Nancy Bunin, Julie-An Talano, Bryon Johnson, Yongping Wang, Mitchell S. Cairo, Blood 138 Supp(): 476, 2021
Optimization of Gating of IFN-Gamma Positive Viral Specific Cytotoxic T-Cells (vCTLs) Following Viral Peptivators® Stimulation Utilizing the Cytokine Capture System on the Clinimacs® Prodigy: Quality Control of the Viral CTL Consortium (VIRCTL)
Olivia Rigot, Janet Ayello, Bernadette Fallon, Lin Marie Colon, Robert Kuhns, Lauren Harrison, Rosemarie Shaw, Sandra Fabricatore, Isabel D Gonzalez, Allyson Flower, Bryon D Johnson, Yongping Wang, Mitchell S Cairo, Transplant Cell Ther 27 3S(): S356, 2021
