PEOPLE

Yongping Wang, MD, PhD

Assistant Professor of Clinical Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationStem Cell Lab, 5NW60 Main Building
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759

Email: wangy2@email.chop.edu

Specialty Division

Immunobiology and Experimental Pathology

Research Expertise

RNAi, library screening, stem cell, erythropoiesis

Clinical Expertise

cGMP cellular therapy, stem cell, bone marrow transplant, mesenchymal stromal cell (MSC), chimeric antigen receptor T cells (CARTs)

Education

B.S. (Molecular Biophysics and Biochemistry; Economics), Yale, 1995
M.D, Ph.D. (Medicine; Pharmacology), Dartmouth Medical School, 2003

Specialty Certification

Clinical Pathology and Transfusion Medicine, 2007
Clinical Pathology and Transfusion Medicine, 2017

Postgraduate Training

Resident, Clinical Pathology, Hospital of University of Pennsylvania, 2003-2008
Fellow, Transfusion Medicine, Hospital of University of Pennsylvania, 2006-2007
Certificate, Clinical Pathology and Transfusion Medicine, University of Pennsylvania, 2007-2007
Post-doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 2008-2009

Awards and Honors

Summer Undergraduate Research Fellowship, California Institute of Technology, 1994
Max Kade Foundation Fellowship, Yale University and Universtität Heidelberg, 1994
Magna Cum Laude, Yale University, 1995
Honors in Economics, Yale University, 1995
Honors in Molecular Biophysics and Biochemistry, Yale University, 1995
Howard Hughes Medical Institute Predoctoral Fellowship, Howard Hughes Medical Institute, 1996-2000
SmithKlein Beecham Student Award, New England Pharmacologists 27th Annual Meeting, 1998
Honor Student, American Academy of Achievements, 2000
The Leonard Berwick Residency Teaching Award, Deptartment of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2006
University of Pennsylvania Medical School, Basic Science Teaching Award, 2006
The William Pepper Resident Award, Dept. of Pathology and Laboratory Medicine, School of Medicine, UPenn, 2007
The Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, 43rd Annual Meeting Philadelphia, Pennsylvania, 2008

Memberships and Professional Organizations

AABB - Association for the Advancement of Blood and Biotherapies, 2007 - present
International Society for Cell and Gene Therapy, 2011 - present
AABB Cellular Therapy Section, Committee on Novel Therapies and CT Product Development, 2014 - Present

Web Links


Selected Publications

Treating Children, Adolescents, and Young Adults (CAYA) with Refractory Viral Infections in Primary Immunodeficiencies (PID), or Post Solid Organ Transplant (SOT) or Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) with Virus Specific T- Lymphocytes (vCTLs)

Jordan Milner, Julie-An Talano, Lauren Harrison, Janet Ayello, Allyson Flower, Yaya Chu, Olivia Rigot, Bryon D Johnson, Yimei Li, Dean Anthony Lee, Rolla Abu-Arja, Julia Chu, Christopher C. Dvorak, Lynn C. O'Donnell, Yongping Wang, Nancy J. Bunin, and Mitch S. Cairo, Pediatric Transplantation & cellular Therapy Consortium annual meeting, 2022

Unrelated donor α/β T-cell and B-cell-depleted HSCT for the treatment of pediatric acute leukemia

Allison Barz Leahy, Yimei Li, Julie-An Talano, Caitlin W. Elgarten, Alix E. Seif, Yongping Wang, Bryon Johnson, Dimitri S. Monos, Stephan Kadauke, Timothy S. Olson, Jason Freedman, Lisa Wray, Stephan A. Grupp, Nancy Bunin, Blood Advances, 2022

Ex Vivo T-Cell Receptor αβ +/CD19 +depletion of Peripheral Stem Cell Grafts for Pediatric Patients with Bone Marrow Failure (BMF) Undergoing Unrelated Donor Transplantation

Joseph H Oved, Caitlin W Elgarten, Yongping Wang, Stephan Kadauke, Dimitri S. Monos, David M. Barrett, Stephan A. Grupp, Nancy Bunin, Timothy S. Olson, Blood 138 Supp(): 171, 2021

Manufacture and Immunological Characterization of GMP-compliant functional SARS-COV-2 cytotoxic T lymphocytes (CTLs) utilizing the CliniMACS Cytokine Capture System

Yaya Chu, Jordan Milner, Margaret Lamb, Elena Maryamchik, Olivia Rigot, Janet Ayello, Lauren Harrison, Rosemarie Shaw, Greg K. Behbehani, Elaine R. Mardis, Katherine E Miller, Lakshmi Prakruthi Rao Venkata, Hsiaochi Chang, Dean Anthony Lee, Elana Y. Rosenthal, Stephan Kadauke, Nancy Bunin, Julie-An Talano, Bryon Johnson, Yongping Wang, Mitchell S. Cairo, Blood 138 Supp(): 476, 2021

Optimization of Gating of IFN-Gamma Positive Viral Specific Cytotoxic T-Cells (vCTLs) Following Viral Peptivators® Stimulation Utilizing the Cytokine Capture System on the Clinimacs® Prodigy: Quality Control of the Viral CTL Consortium (VIRCTL)

Olivia Rigot, Janet Ayello, Bernadette Fallon, Lin Marie Colon, Robert Kuhns, Lauren Harrison, Rosemarie Shaw, Sandra Fabricatore, Isabel D Gonzalez, Allyson Flower, Bryon D Johnson, Yongping Wang, Mitchell S Cairo, Transplant Cell Ther 27 3S(): S356, 2021

Immune Reconstitution Following TCRαβ/CD19-Depleted Hematopoietic Cell Transplantation for Hematologic Malignancy in Pediatric Patients

Danielle E. Arnold, Derek MacMath, Alix E. Seif, Jennifer R. Heimall, Yongping Wang, Dimitri Monos, Stephan A. Grupp, Nancy J. Bunin, Transplantation and Cellular Therapy 27(2): 169.e1, 2021

Outcomes and Challenges of Manufacturing Virus-Specific Cytotoxic T-lymphocytes Using IFN-gamma Cytokine Capture System

Elena Maryamchik MD, Stephan Kadauke MD PHD, Allyson Flower, MD, Barrett, David MD PhD, Janet Ayello, MS, MT, Lauren Harrison, RN, MSN, Erin Morris, RN , Meghan Sturhahn, RN, MSN, Lynn O’Donnell, PHD, Dean Lee, MD, PHD, Rolla Abu-Arja, MD, Bryon Johnson MD PHD, Julie Talano MD, Mitchell S. Cairo, MD, Nancy Bunin, MD, Yongping Wang, MD, PHD, International Society for Cell and Gene Therapy annual meeting, Paris, France (virtual), 2020

Low CD45 Expression Predicts Poor Post-Thaw CD34 Cell Viability

Elena Maryamchik MD, Xingwu Zheng, Xiaoyong Zhang, Rene Machietto, Colleen Finn, Nicholas Giacobbe, Mario Quant, Shilpa Choudhari, Stephan Kadauke MD PhD, Yongping Wang MD PhD, International Society for Cell and Gene Therapy annual meeting, Paris, France (virtual), 2020

Partially CD3+-Depleted Unrelated and Haploidentical Donor Peripheral Stem Cell Transplantation Has Favorable Graft-versus-Host Disease and Survival Rates in Pediatric Hematologic Malignancy

Alix E. Seif, Yimei Li, Dimitri S. Monos, Stephanie C. Heideman, nRichard Aplenc, David M. Barrett, James T. Casper, Jason L. Freedman, Stephan A. Grupp, David A. Margolis, Timothy S. Olson, David T. Teachey, Carolyn A. Keever-Taylor, Yongping Wang, Julie-An M. Talano, Nancy J. Bunin, Biology of Blood and Marrow Transplantation 26(): 493-501, 2020

The Safety and Efficacy of Targeted Virus Specific Cytotoxic T-lymphocytes Manufactured by the IFN-g Cytokine Capture System (CCS) for the Treatment of Refractory Adenovirus (ADV), cytomegalovirus (CMV), Epstein Barr Virus (EBV) and BK Virus (BKV) in Children, Adolescents and Young Adults after Allogenic Hematopoietic Stem Cell Transplantation (Allo-HSCT), Solid Organ Transplantation (SOT), or with Primary Immunodeficiency (PID).

Allyson Flower, Janet Ayello, Lauren Harrison, Erin Morris, Meghan Sturhan, Elena Maryamchik, Yongping Wang, Lynn O’Donnell, Dean Lee, Julie Talano, Bryon Jonson, Mitchell S. Cairo, Nancy Bunin., American Society of Transplantation & Cellular Therapy annual meeting. Orlando, FL., 2020