Gerald B. Wertheim, MD, PhD
Associate Professor of Clinical Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736
Email: wertheimg@email.chop.edu
Itmat Expertise
DNA methylation
Acute myeloid leukemia prognosis
Education
BS (Chemistry), Yale University, New Haven CT, 1994
PhD (Cancer Biology), University of Pennsylvania School of Medicine, 2004
MD (Medicine), University of Pennsylvania School of Medicine, 2005
Specialty Certification
American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011
Postgraduate Training
Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011
Awards and Honors
Phi Beta Kappa, Yale University, 1993
The Werner Bergmann Award in Chemistry, Yale University, 1994
summa cum laude, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012
Memberships and Professional Organizations
American Society of Hematology, 2015 - Present
Society of Hematopathology, 2015 - Present
The United States and Canadian Academy of Pathology, 2015 - Present
Selected Publications
Selective Sensitivity of Ph-like B-Cell Acute Lymphoblastic Leukemia to BRG1 Inhibition Identifies a Therapeutic Vulnerability
Hurtz C, Ayyadevara VSSA, Perencsik R, Patil S, Gaur S, Paik A, Toma M, Wertheim GB, Geng H, Skorski T, Swaminathan S, Leukemia, 2026
Upfront menin-inhibitor resistance in multiply pretreated leukemias
Mahdavi L, Alikarami F, Goodrow H, Lenard A, Riedel SS, Libbrecht C, Bowser I, Tasian SK, Falkenstein CD, Manning B, Skuli S, Carroll MP, Wertheim GB, Cai SF, McGeehan G, Yu S, Shi J, Xie HM, Bernt KM, Experimental Hematology 153(): , 2026, PMID:41027490
A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis
Mansoori B, Song Y, Zhang T, Zheng Z, Zhu Q, Li S, Reale M, Pangilinan C, Machhar JS, Liang J, Chang J, Hong YK, Wertheim GB, Murphy ME, Kim YM, Muschen M, Gack MU, Kossenkov AV, Liu Q, Auslander N, Aifantis I, Parekh C, Liang C, bioRxiv, 2025, PMID:41446230
Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia
Newman H, Wong D, Wu J, Schubert J, Golenberg N, Naveh N, Patel M, Xu F, Charles S, Chen J, Denenberg EH, Fanning EA, Gallo D, Luke T, Thomas M, Cao K, Chan AJS, Holloman M, Fan Z, Fu W, Hunger SP, MacFarland SP, Bernt KM, Surrey LF, Luo M, Wertheim GB, Li MM, Tasian SK, Zhong Y, HemaSphere 9(11): , 2025, PMID:41306327
Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate
Buono R, Juarez D, Paul M, Skuli SJ, Wong IB, Tarnekar I, Ying Z, Le I, Wertheim GB, Bakayoko A, Kruidenier M, Sebti SM, Konopleva M, Fleischman AG, Jang C, Carroll M, Fruman DA, bioRxiv, 2025, PMID:41280002
Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response
Skuli SJ, Bakayoko A, Kruidenier M, Manning B, Pammer P, Salimov A, Riley O, Brake-Sillá G, Dopkin D, Bowman M, Martinez-Gutierrez LN, Anderson CC, Reisz JA, Buono R, Paul M, Saland E, Liccardo F, DeVine A, Wong S, Xu JP, Nee E, Hausler R, Boettcher S, Sebti SM, Lai C, Maxwell KN, Sarry JE, Fruman DA, D'Alessandro A, Mesaros C, Keith B, Simon MC, Sung PJ, Wertheim GB, Skuli N, Bowman RL, Matthews A, Carroll M, Leukemia 39(9): , 2025, PMID:40634510
Integrated genomic analysis to reduce chromosomal analysis for the diagnosis of pediatric hematologic malignancies: addressing the shortage of cytogenetic technologists
Li D, Tasian SK, Wertheim G, Rheingold SR, Bernt KM, Newman H, Wainwright L, Wilmoth DM, Thiel B, Surrey LF, Margolskee E, Pillai V, Luo M, Paessler ME, Hunger SP, Li MM, Zhong Y, Haematologica 110(8): 1861-1864, 2025, PMID:39882648
Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy Strategy
Ayyadevara VSSA, Gaur S, Paik A, Perencsik R, Toma M, Wertheim GB, Geng H, Skorski T, Swaminathan S, Hurtz C, bioRxiv, 2025, PMID:40672274
Azacytidine Monotherapy in an Infant With Mosaic NRAS-Driven Juvenile Myelomonocytic Leukemia
Grenier JM, Tasian SK, Stieglitz E, Abdullaev Z, Wertheim GB, Li MM, Phillips CA, Pediatric Blood & Cancer 72(5): , 2025, PMID:40040253
Genetically Distinct Acute Megakaryoblastic Leukemia following Low Hypodiploid B-Lymphoblastic Leukemia linked by TP53 Mutation
Harris JC, Schubert J, Lockhart B, Olson R, Paessler ME, Margolskee E, Pillai V, Wu J, Golenberg N, Chen J, Denenberg EH, Luke T, Luo M, Zhong Y, Li MM, Wertheim GB, Pediatric and Developmental Pathology 28(3): 214 - 219, 2025, PMID:39898462
