Gerald B. Wertheim, MD, PhD

Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736


Itmat Expertise

DNA methylation
Acute myeloid leukemia prognosis


BS (Chemistry), Yale University, New Haven CT, 1994
PhD (Cancer Biology), University of Pennsylvania School of Medicine, 2004
MD (Medicine), University of Pennsylvania School of Medicine, 2005

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011

Postgraduate Training

Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011

Awards and Honors

Phi Beta Kappa, Yale University, 1993
summa cum laude, Yale University, 1994
The Werner Bergmann Award in Chemistry, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012

Memberships and Professional Organizations

The United States and Canadian Academy of Pathology, 2015 - Present
Society of Hematopathology, 2015 - Present
American Society of Hematology, 2015 - Present

Selected Publications

Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia

Regina M Myers, Yimei Li, Allison Barz Leahy, David M Barrett, David T Teachey, Colleen Callahan, Christina C Fasano, Susan R Rheingold, Amanda DiNofia, Lisa Wray, Richard Aplenc, Diane Baniewicz, Hongyan Liu, Pamela A Shaw, Edward Pequignot, Kelly D Getz, Jennifer L Brogdon, Andrew D Fesnak, Donald L Siegel, Megan M Davis, Chelsie Bartoszek, Simon F Lacey, Elizabeth O Hexner, Anne Chew, Gerald B Wertheim, Bruce L Levine, Carl H June, Stephan A Grupp, Shannon L Maude, Journal of Clinical Oncology, 2021, PMID:34156874

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Blinatumomab Induces Bone Marrow Lymphoid Infiltrates That Correlate with Response in B-ALL

Lytle A, Pillai V, Wertheim GW, Paessler M, Croy C and Rheingold S, United States and Canadian Academy of Pathology 2021 Baltimore, Maryland, 2021

Morphological and Immunophenotypic Characterization of CAR T Cells

Wei J, Faude S, Xu X, Wertheim G, Paessler M, Bhoj V, Pillai V, United States and Canadian Academy of Pathology 2021 Baltimore, Maryland, 2021

Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial

Kadauke S, Myers RM, Li Y, Aplenc R, Baniewicz D, Barrett DM, Barz Leahy A, Callahan C, Dolan JG, Fitzgerald JC, Gladney W, Lacey SF, Liu H, Maude SL, McGuire R, Motley LS, Teachey DT, Wertheim GB, Wray L, DiNofia AM, Grupp SA, Journal of Clinical Oncology 39(8): 920-930, 2021, PMID:33417474

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NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome

Zhao X, Kotch C, Fox E, Surrey LF, Wertheim GB, Baloch ZW, Lin F, Pillai V, Luo M, Kreiger PA, Pogoriler JE, Linn RL, Russo PA, Santi M, Resnick AC, Storm PB, Hunger SP, Bauer AJ and Li MM, JCO Precision Oncology 5(): 204-214, 2021, PMID:34036219

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Pathology and Molecular Diagnosis of Leukemias and Lymphomas

Margolskee E, Wertheim GBW, Harvey RC, Pizzo and Poplack's Pediatric Oncology 8th Edition, 2021

Eosinophilia/Hypereosinophilia in the Setting of Reactive and Idiopathic Causes, Well-Defined Myeloid or Lymphoid Leukemias, or Germline Disorders

Kelemen K, Saft L, Craig FE, Orazi A, Nakashima M, Wertheim GB, George TI, Horny HP, King RL, Quintanilla-Martinez L, Wang SA, Rimsza LM, Reichard KK, American journal of clinical pathology 155(2): 179-210, 2020, PMID:33367563

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A Novel KMT2A-ARHGEF12 Fusion Gene Identified in a High-Grade B-cell Lymphoma

Jung HS, Lin F, Wolpaw A, Reilly AF, Margolskee E, Luo M, Wertheim GB, Li MM, Cancer Genetics, 2020, PMID:32805689

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Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL

Hurtz C, Wertheim GB, Loftus JP, Blumenthal D, Lehman A, Li Y, Bagashev A, Manning B, Cummins KD, Burkhardt JK, Perl AE, Carroll M, Tasian SK, The Journal of Clinical Investigation 130(7): 3637-3653, 2020, PMID:32191635

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Evolution of Histomorphologic, Cytogenetic, and Genetic Abnormalities in an Untreated Patient With MIRAGE Syndrome

Rentas S, Pillai V, Wertheim GB, Akgumus GT, Nichols KE, Deardorff MA, Conlin LK, Li MM, Olson TS, Luo M, Cancer Genetics 245(): 42-48, 2020, PMID:32619790

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