PEOPLE

Gerald B. Wertheim, MD, PhD

Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736

Email: wertheimg@email.chop.edu

Itmat Expertise

DNA methylation
Acute myeloid leukemia prognosis

Education

BS (Chemistry), Yale University, New Haven CT, 1994
PhD (Cancer Biology), University of Pennsylvania School of Medicine, 2004
MD (Medicine), University of Pennsylvania School of Medicine, 2005

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011

Postgraduate Training

Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011

Awards and Honors

Phi Beta Kappa, Yale University, 1993
summa cum laude, Yale University, 1994
The Werner Bergmann Award in Chemistry, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012

Memberships and Professional Organizations

The United States and Canadian Academy of Pathology, 2015 - Present
Society of Hematopathology, 2015 - Present
American Society of Hematology, 2015 - Present

Selected Publications

Identification of TP53 Germline Variants in Pediatric Patients Undergoing Tumor Testing: Strategy and Prevalence

Luo M, Wong D, Zelley K, Wu J, Schubert J, Denenberg EH, Fanning EA, Chen J, Gallo D, Golenberg N, Patel M, Conlin LK, Maxwell KN, Wertheim GB, Surrey LF, Zhong Y, Brodeur GM, MacFarland SP, Li MM, J Natl Cancer Inst, 2024, PMID:38702830

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Reinfusion of CD19 CAR T Cells for Relapse Prevention and Treatment in Children With Acute Lymphoblastic Leukemia

Myers RM, Devine K, Li Y, Lawrence S, Barz Leahy A, Liu H, Vernau L, Callahan C, Baniewicz D, Kadauke S, McGuire R, Wertheim GB, Kulikovskaya I, Gonzalez VE, Fraietta JA, DiNofia Am, Hunger SP, Rheingold SR, Aplenc R, June CH, Grupp SA, Wray L, Maude SL, Blood Adv 14(8): 2182-2192, 2024, PMID:38386999

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Condensate-promoting ENL Mutation Drives Tumorigenesis in Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression

Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L, Cancer Discov, 2024, PMID:38655899

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FLT3 Tyrosine Kinase Inhibition Modulates PRC2 and Promotes Differentiation in Acute Myeloid Leukemia

Sung PJ, Selvam M, Riedel SS, Xie HM, Bryant K, Manning B, Wertheim GB, Kulej K, Pham L, Bowman RL, Peresie J, Nemeth MJ, Levine RL, Garcia BA, Meyer SE, Sidoli S, Bernt KM, Carroll M, Leukemia 38(2): 291-301, 2024, PMID:38182819

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Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing

Newman H, Egan Clark M, Wong D, Wu J, Brodeur GM, Hunger SP, Tasian SK, Olson T, Warren JT, Teachey DT, Bona K, Schubert J, Golenberg N, Patel M, Denenberg EH, Fanning EA, Chen J, Luke T, Charles S, Gallo D, Cao K, Fu W, Fan Z, Surrey LF, Wertheim G, Luo M, MacFarland SP, Li MM, Zhong Y, Haematologica, 2024, PMID:38385299

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A Novel Cryopreservation and Biobanking Strategy to Study Lymphoid Tissue Stromal Cells in Human Disease

Brandstadter JD, De Martin A, Lϋtge M, Ferreira A, Gaudette BT, Stanossek Y, Shumei Wang 3, Gonzalez MV, Camiolo E, Wertheim G, Austin B, Allman D, Bagg A, Lim MS, Fajgenbaum DC, Aster JC, Ludewig B, Maillard I, Eur J Immunol 53(9): e2250362, 2023, PMID:37366295

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Co-Occurrence of Pallister-Killian Syndrome and Burkitt Lymphoma in a Patient with Near-Normal Neurocognitive Development

Izumi K, Ganetzky RD, Wertheim G, Skraban CM, Bedoukian EC, Wilkens A, Fincher C, Thomas NH, Ginsberg JP, Rheingold SR, Conlin LK, Deardorff MA, Mol Syndromol 14(4): 303-309, 2023, PMID:37589028

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Iris and Orbital Myeloid Sarcoma in a Pediatric Patient

Qin VL, Verkuil L, Zangeaneh T, Wertheim G, Davidson SL, J AAPOS 27(3): , 2023, PMID:37207926

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Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole Genome Sequencing of Hodgkin and Reed Sternberg Cells

Maura F, Ziccheddu B, Xiang JZ, Bhinder B, Rosiene J, Abascal F, Maclachlan KH, Eng KW, Uppal M, He F, Zhang W, Gao Q, Yellapantula VD, Trujillo-Alonso V, Park SI, Oberley MJ, Ruckdeschel E, Lim MS, Wertheim GB, Barth MJ, Horton TM, Derkach A, Kovach AE, Forlenza CJ, Zhang Y, Landgren O, Moskowitz CH, Ethel Cesarman E, Imielinski M, Elemento O, Roshal M, Giulino-Roth L, Blood Cancer Discovery 4(3): 208-227, 2023, PMID:36723991

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