Qian Zhang, MD, PhD
Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Contact InformationUniversity of Pennsylvania School of Medicine
Department of Pathology & Laboratory Medicine
Stellar Chance Laboratories Building
422 Curie Blvd.
413A/Stellar Chance
Philadelphia, PA 19104
Office: 215-573-5468
Email: qian2@pennmedicine.upenn.edu
Specialty Division
Cancer and Immunobiology
Research Expertise
Lymphomas and other hematologic malignancies
The pathogenesis of lymphomas and, more specifically, on the role of aberrant signal transduction in malignant transformation of lymphocytes. The area of signal transduction in lymphomas and other hematopoietic and non-hematopoietic malignancies has far reaching basic, diagnostic, and therapeutic implications.
Education
M.D. Xi'an Medical University, Xian, China, 1986
Ph.D. Institute for Medical Microbiology and Immunology University of Copenhagen, Copenhagen, Denmark, 2000
Specialty Certification
Postgraduate Training
Resident Physician, Internal Medicine , The 5th Hospital of Xi'an, Xi'an, China, 1986-1989
Postdoctoral Research Fellow, Department of Medicine, Pulmonary and Critical Care Division , University of Pennsylvania School of Medicine, Philadelphia, PA, 1993-1994
Postdoctoral Research Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 1994-1997
Awards and Honors
Award of Excellent Student in Xi'an Medical University, 1981-1982
Award of Foundation of Chinese Medical Association, 1990-1990
Memberships and Professional Organizations
American Association for Cancer Research, 2010 - Present
American Society of Hematology, 2011 - Present
Selected Publications
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.
Zhang Q, Wang HY, Woetmann A, Raghunath PN, Odum N, Wasik, MA, Blood 108(3): 1058-1064, 2006, PMID:16861352
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
Kasprzycka M, Majewski M, Wang ZJ, Ptasznik A, Wysocka M, Zhang Q, Marzec M, Gimotty P, Crompton MR, Wasik MA, Am J Pathol. 168(5): 1631-1641, 2006, PMID:16651629
Chromatin Modification Pathways.
Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA, Keystone Symposium, 2005
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.
Marzec M, Kasprzycka M, Ptasznik A, Wlodarski P, Zhang Q, Odum N, Wasik MA, Lab Invest. 85(12): 1544-1554, 2005, PMID:16170336
Detection of protein tyrosine-kinase (PTK) gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresis.
Wang ZY, Zhang Q, Wilson J, Ratajczak MZ, Wasik MA, J Mol Diagn. 5(2): 113-120, 2003, PMID:12707376
Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeric base stretches.
Zhang Q, Capocasale R, Fox FE, Bedian V, Vonderheid EC, Moore JS, Nowell PC, Haines DS, Wasik MA, Arch Immunol Ther Exp. (Warsz) 50(6): 419-427, 2002, PMID:12546068
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma.
Zhang Q, Raghunath PN, Majewski M, Carpentieri DF, Xuen L, Odum N, Morrise S, Skorski T, Wasik MA, J Immunol. 168(1): 466-474, 2002, PMID:11751994
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
Zhang Q, Nowak I, Vonderheid EC, Rook AH, Kadin ME, Nowell PC, Shaw LM, Wasik MA, Proc Natl Acad Sci USA. 93(17): 9148-9153, 1996, PMID:8799169
Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.
Nieborowska-Skorska M, Slupianek A, Xue L, Zhang Q, Raghunath PN, Hoser G, Wasik MA, Morris SW, Skorski T, Cancer Res. 61(17): 6517-6523, 2001, PMID:11522649
Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders.
Paessler M, Kossev P, Tsai D, Raghunath PN, Majewski M, Zhang Q, Ramalingam P, Schuster S, Tomaszewski J, Arber D, Hsi E, Wasik MA, Lab Invest. 82(11): 1599-1606, 2002, PMID:12429820
SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells.
Brockdorff JL, Woetmann A, Mustelin T, Kaltoft K, Zhang Q, Wasik MA, Ropke C, Odum N, Cytokine 20(4): 141-147, 2002, PMID:12543077
