Qian Zhang, MD, PhD

Research Associate Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine

Contact InformationUniversity of Pennsylvania School of Medicine
Department of Pathology & Laboratory Medicine
Stellar Chance Laboratories Building
422 Curie Blvd.
413A/Stellar Chance
Philadelphia, PA 19104
Office: 215-573-5468


Specialty Division

Cancer and Immunobiology

Research Expertise

Lymphomas and other hematologic malignancies

The pathogenesis of lymphomas and, more specifically, on the role of aberrant signal transduction in malignant transformation of lymphocytes. The area of signal transduction in lymphomas and other hematopoietic and non-hematopoietic malignancies has far reaching basic, diagnostic, and therapeutic implications.


M.D. Xi'an Medical University, Xian, China, 1986
Ph.D. Institute for Medical Microbiology and Immunology University of Copenhagen, Copenhagen, Denmark, 2000

Specialty Certification

Postgraduate Training

Resident Physician, Internal Medicine , The 5th Hospital of Xi'an, Xi'an, China, 1986-1989
Postdoctoral Research Fellow, Department of Medicine, Pulmonary and Critical Care Division , University of Pennsylvania School of Medicine, Philadelphia, PA, 1993-1994
Postdoctoral Research Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 1994-1997

Awards and Honors

Award of Excellent Student in Xi'an Medical University, 1981-1982
Award of Foundation of Chinese Medical Association, 1990-1990

Memberships and Professional Organizations

American Association for Cancer Research, 2010 - Present
American Society of Hematology, 2011 - Present

Selected Publications

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.

Zhang Q, Wang HY, Woetmann A, Raghunath PN, Odum N, Wasik, MA, Blood 108(3): 1058-1064, 2006, PMID:16861352

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Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

Kasprzycka M, Majewski M, Wang ZJ, Ptasznik A, Wysocka M, Zhang Q, Marzec M, Gimotty P, Crompton MR, Wasik MA, Am J Pathol. 168(5): 1631-1641, 2006, PMID:16651629

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Chromatin Modification Pathways.

Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA, Keystone Symposium, 2005

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

Marzec M, Kasprzycka M, Ptasznik A, Wlodarski P, Zhang Q, Odum N, Wasik MA, Lab Invest. 85(12): 1544-1554, 2005, PMID:16170336

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Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma.

Zhang Q, Raghunath PN, Majewski M, Carpentieri DF, Xuen L, Odum N, Morrise S, Skorski T, Wasik MA, J Immunol. 168(1): 466-474, 2002, PMID:11751994

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Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.

Nieborowska-Skorska M, Slupianek A, Xue L, Zhang Q, Raghunath PN, Hoser G, Wasik MA, Morris SW, Skorski T, Cancer Res. 61(17): 6517-6523, 2001, PMID:11522649

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Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders.

Paessler M, Kossev P, Tsai D, Raghunath PN, Majewski M, Zhang Q, Ramalingam P, Schuster S, Tomaszewski J, Arber D, Hsi E, Wasik MA, Lab Invest. 82(11): 1599-1606, 2002, PMID:12429820

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SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells.

Brockdorff JL, Woetmann A, Mustelin T, Kaltoft K, Zhang Q, Wasik MA, Ropke C, Odum N, Cytokine 20(4): 141-147, 2002, PMID:12543077

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