Jorge Henao-Mejia, MD, PhD

Associate Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact InformationThe Institute for Immunology
Perelman School of Medicine at the University of Pennsylvania
421 Curie Boulevard
Biomedical Research Building II/III, Room 312
Philadelphia, PA, 19104


Specialty Division

Immunobiology and Experimental Pathology


M.D. (Medicine), University of Antioquia, Colombia, 2005
Ph.D. (Microbiology and Immunology), Indiana University, 2009

Specialty Certification

Postgraduate Training

Postdoctoral Fellow, Immunology & Microbiology, Indiana University, Indianapolis, IN, USA., 2009-2009
HHMI Fellow, Howard Hughes Medical Institute, Immunobiology, Yale University, New Haven, CT, USA., 2009-2010
Postdoctoral Fellow, Immunobiology, Yale University, New Haven, CT, USA., 2010-2014

Awards and Honors

Esther, L. Kinsley, Ph.D., Dissertation Award, Indiana University, 2009-2009
Young Investigator Award - 16th Conference on Retroviruses and Opportunistic Infections, 2009-2009
Under represented Minority Scholarship, Keystone Symposia on non-coding RNAs, 2011-2011
PEW Biomedical Scholar, 2017-2021
Burroughs Wellcome Fund-Investigator in the Pathogenesis of Infectious Disease Award, 2018-2023

Memberships and Professional Organizations

The American Association for the Advancement of Science, 2009 - Present
American Association of Immunology, 2017 - Present

Web Links

Selected Publications

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J., Nature 537(7619): , 2016

Generation of genetically modified mice using the CRISPR/Cas9 genome editing system

Henao-Mejia J*, Williams A*, Rongvaux A, Stein J, Hughes C, Flavell RA* (*Corresponding authors), Cold Spring Harb Protoc., 2016

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Henao-Mejia J*, Elinav E*, Jin C*, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA, Nature 482(7384): 179-185, 2012

The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.

Henao-Mejia J,* Williams A*, Goff LA, Staron M, Licona-Limon P, Kaech SM, Nakayama M, Rinn JL, Flavell, Immunity 38(5): 1-14, 2013

Inflammasomes in health and disease.

Henao-Mejia J*, Strowig T*, Elinav E*, Flavell R, Nature 481(7381): 278-286, 2012

Inflammasomes and Metabolic Disease

Henao-Mejia J.*, Elinav E*, Thaiss CA*, Flavell RA, Annu Rev Physiol 76(): 57-78, 2014

NLRP6 inflammasome regulates the intestinal host-microbial interface by orchestrating globlet cell-mediated mucus secretion

Wlodarska M, Nowarski R, Thaiss CA, Henao-Mejia J, Zhang JP, Frankel G, Hao L, Philbrick WM, Elinav E, Finlay BB, Flavell RA, Cell 156(5): 1045-1059, 2014

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

Elinav E,* Strowig T,* Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA, Cell 145(5): 745-757, 2011

Trans-chromosomal and nuclear matrix interactions require a lincRNA that escapes X chromosome inactivation

Hacisuleyman E., Goff LA, Trapnell C, Sauvageau DC, Hendrickson DR, Kelley P, McClanahan A, Henao-Mejia J, Sun L, Engreitz J, Guttman M, Lander ES, Flavell RA, Lodish HF, Raj A, Rinn JL, Nat Struct Mol Biol 21(2): 198-206, 2014

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

Eisenbarth SC*, Williams A*, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA, Nature 484(7395): 510-513, 2012