Jorge Henao-Mejia, MD, PhD
Associate Professor of Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationThe Institute for Immunology
Perelman School of Medicine at the University of Pennsylvania
421 Curie Boulevard
Biomedical Research Building II/III, Room 312
Philadelphia, PA, 19104
Email: jhena@pennmedicine.upenn.edu
Specialty Division
Cancer and Immunobiology
Education
M.D. (Medicine), University of Antioquia, Colombia, 2005
Ph.D. (Microbiology and Immunology), Indiana University, 2009
Specialty Certification
Postgraduate Training
HHMI Fellow, Howard Hughes Medical Institute, Immunobiology, Yale University, New Haven, CT, USA., 2009-2010
Postdoctoral Fellow, Immunology & Microbiology, Indiana University, Indianapolis, IN, USA., 2009-2009
Postdoctoral Fellow, Immunobiology, Yale University, New Haven, CT, USA., 2010-2014
Awards and Honors
Esther, L. Kinsley, Ph.D., Dissertation Award, Indiana University, 2009-2009
Young Investigator Award - 16th Conference on Retroviruses and Opportunistic Infections, 2009-2009
Under represented Minority Scholarship, Keystone Symposia on non-coding RNAs, 2011-2011
PEW Biomedical Scholar, 2017-2021
Burroughs Wellcome Fund-Investigator in the Pathogenesis of Infectious Disease Award, 2018-2023
Memberships and Professional Organizations
The American Association for the Advancement of Science, 2009 - Present
American Association of Immunology, 2017 - Present
Web Links
Selected Publications
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J., Nature 537(7619): , 2016
Generation of genetically modified mice using the CRISPR/Cas9 genome editing system
Henao-Mejia J*, Williams A*, Rongvaux A, Stein J, Hughes C, Flavell RA* (*Corresponding authors), Cold Spring Harb Protoc., 2016
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia J*, Elinav E*, Jin C*, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA, Nature 482(7384): 179-185, 2012
The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.
Henao-Mejia J,* Williams A*, Goff LA, Staron M, Licona-Limon P, Kaech SM, Nakayama M, Rinn JL, Flavell, Immunity 38(5): 1-14, 2013
Inflammasomes in health and disease.
Henao-Mejia J*, Strowig T*, Elinav E*, Flavell R, Nature 481(7381): 278-286, 2012
Inflammasomes and Metabolic Disease
Henao-Mejia J.*, Elinav E*, Thaiss CA*, Flavell RA, Annu Rev Physiol 76(): 57-78, 2014
NLRP6 inflammasome regulates the intestinal host-microbial interface by orchestrating globlet cell-mediated mucus secretion
Wlodarska M, Nowarski R, Thaiss CA, Henao-Mejia J, Zhang JP, Frankel G, Hao L, Philbrick WM, Elinav E, Finlay BB, Flavell RA, Cell 156(5): 1045-1059, 2014
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
Elinav E,* Strowig T,* Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA, Cell 145(5): 745-757, 2011
Trans-chromosomal and nuclear matrix interactions require a lincRNA that escapes X chromosome inactivation
Hacisuleyman E., Goff LA, Trapnell C, Sauvageau DC, Hendrickson DR, Kelley P, McClanahan A, Henao-Mejia J, Sun L, Engreitz J, Guttman M, Lander ES, Flavell RA, Lodish HF, Raj A, Rinn JL, Nat Struct Mol Biol 21(2): 198-206, 2014
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells
Eisenbarth SC*, Williams A*, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA, Nature 484(7395): 510-513, 2012
