Daniel S. Herman, MD, PhD
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Director, Endocrine Laboratory
Contact Information3700 Hamilton Walk
Richards Building, B202
Philadelphia, PA 19104
Office: 215-662-6575
Fax: 215-662-7529
Email: daniel.herman2@pennmedicine.upenn.edu
Specialty Division
Laboratory Medicine
Itmat Expertise
I am interested in leveraging existing clinical data and developing new biomarker-based strategies for screening for under diagnosed diseases, including causes of secondary hypertension.
Clinical Expertise
Laboratory Medicine, Biomedical informatics, Clinical Chemistry, Pathology Informatics, Cardiac Biomarkers.
Research Expertise
My research interests are in the pragmatic prediction of disease and in developing systems to improve the interpretation of clinical laboratory results. Current areas of research include:
1) Leveraging electronic health record data to screen for underdiagnosed diseases, including secondary hypertension
2) Developing and implementing computational tools to improve the quality of clinical laboratory results and facilitate context-dependent interpretation
3) Improving the prediction of primary cardiovascular disease by assessing the gap between existing biomarkers and the clinical needs
Education
BS (Bachelor of Science in Biology), Massachusetts Institute of Technology, 2004
PhD (Doctorate of Philosophy in Genetics), Harvard Medical School, Division of Medical Sciences (MSTP), 2011
MD (Doctorate of Medicine), Harvard Medical School, Health Sciences and Technology (MSTP), 2013
Specialty Certification
Pathology, CP, 2016
Postgraduate Training
Resident in Clinical Pathology, Department of Pathology and Laboratory Medicine, University of Washington, 2013-2016
Chief Resident in Clinical Pathology, Department of Pathology and Laboratory Medicine, University of Washington, 2014-2015
Awards and Honors
Association for Pathology Informatics 2015 Travel Award, 2015-2015
ACLPS Young Investigator Award, 2015-2015
Best Abstract for the AACC's Biomarkers of Acute Cardiovascular Disease Division, 2015-2015
UW Strandjord-Clayson Award, 2016-2016
McCabe Fund Pilot Award, 2016-2018
ACLPS Young Investigator Award, 2016-2016
CAP Foundation Leadership Development Award, 2016-2016
American Association of Clinical Chemistry, Philadelphia Section, Young Investigator Award, 2018-2018
2023 Humies SILVER Award, Genetic and Evolutionary Computation Conference, 2023-2023
Memberships and Professional Organizations
Phi Beta Kappa, 2004 - 2004
American Physician Scientists Association, 2011 - Present
American Society of Clinical Pathologists, 2013 - Present
College of American Pathology, 2013 - Present
Association for Molecular Pathology, 2014 - 2015
Academy of Clinical Laboratory Physicians and Scientists, 2015 - Present
Association for Pathology Informatics, 2015 - Present
American Association of Clinical Chemistry, 2015 - Present
Medical Research Council, United Kingdom, 2016 - 2016
American Medical Association, 2017 - Present
International Society for Computational Biology, 2017 - Present
American Medical Informatics Association, 2017 - Present
Pennsylvania Association of Pathology, 2018 - Present
Roche Diagnostics, 2019 - 2019
Blueprint Medicines Systemic Mastocytosis Pathology/Hematopathology Advisory Board, 2021 - 2021
Department of Health and Human Services program on Systemic Harmonization and Interoperability Enhancement for Laboratory Data (SHIELD), SHIELD Strategic Planning Implementation Committee, member, 2021 - Present
Web Links
Selected Publications
A maximum likelihood approach to electronic health record phenotyping using positive and unlabeled patients
Lingjiao Zhang, Xiruo Ding, Yanyuan Ma, Naveen Muthu, Imran Ajmal, Jason H. Moore, Daniel S. Herman*, Jinbo Chen*; * Co-corresponding, J Am Med Inform Assoc. 27(1): 119 - 26, 2020, PMID:31722396
Artificial Intelligence and Mapping a New Direction in Laboratory Medicine: A Review
Herman DS, Rhoads DD, Schulz WL, Durant TJS, Clin Chem 67 (11)(): 1466 - 82, 2021, PMID:34557917
Falsely Increased Plasma Lactate Dehydrogenase without Hemolysis Following Transport Through Pneumatic Tube System
Daniel S Herman, Eseraldo Toro, Ezra G. Baraban, Adam Bagg, Ping Wang, JALM 4(3): 433 - 38, 2019, PMID:31659082
Efficient Detection of Copy Number Mutations in PMS2 Exons with Close Homologs: Detection of Copy Number Variants in 3' PMS2 Exons
Herman DS, Smith C, Liu C, Vaughn CP, Palaniappan S, Pritchard CC, Shirts BH, J Mol Diagn 20(4): 512-521, 2018, PMID:29792936
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts AM*, Ware JS*, Herman DS*, Schafer S, Baksi J, Bick AG, Buchan RJ, Walsh R, John S, Wilkinson S, Mazzarotto F, Felkin LE, Gong S, MacArthur JA, Cunningham F, Flannick J, Gabriel SB, Altshuler DM, Macdonald PS, Heinig M, Keogh AM, Hayward CS, Banner NR, Pennell DJ, O'Regan DP, San TR, de Marvao A, Dawes TJ, Gulati A, Birks EJ, Yacoub MH, Radke M, Gotthardt M, Wilson JG, O'Donnell CJ, Prasad SK, Barton PJ, Fatkin D, Hubner N, Seidman JG, Seidman CE, Cook SA., Sci Transl Med 7(270): 270ra6, 2015, PMID:25589632
Endogenous alkaline phosphatase interference in cardiac troponin I and other sensitive chemiluminescence immunoassays that use alkaline phosphatase activity for signal amplification.
Herman DS, Ranjitkar P, Yamaguchi D, Grenache DG, Greene DN., Clin Biochem 49(15): 1118-1121, 2016, PMID:27317886
Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study Cohorts.
Bick AG, Flannick J, Ito K, Cheng S, Ramachandran VS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel S, Funke BH, Rehm HL, Benjamin E, Aragam J, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, O’Donnell C, Wilson JG, Altshuler DL, Hirschhorn JN, Seidman JG, Seidman C., Am J Hum Gen 91(3): 513-9, 2012, PMID:22958901
Truncations of Titin Causing Dilated Cardiomyopathy.
Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE., N Engl J Med. 366(7): 619-28, 2012, PMID:22335739
Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection.
Herman DS, Hovingh GK, Iartchouk O, Rehm HL, Kucherlapati R, Seidman JG, Seidman CE., Nat Methods 6(7): 507-10, 2009, PMID:19543287
