Anupma Nayak, MBBS, MD

Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania

Contact InformationHospital of the University of Pennsylvania
6 Founders Building
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.4899


Specialty Division

Anatomic Pathology

Research Expertise

Breast Cancer

Itmat Expertise

Breast Cancer
Genitourinary Cancers

Clinical Expertise

Breast Pathology
Genitourinary Pathology


MBBS (Medicine), King George Medical College, Lucknow, India, 1997

Specialty Certification

Anatomic Pathology, American Board of Pathology, 2010

Postgraduate Training

Intern, Dr. Shyama Prasad Mukherjee Hospital (Civil Hospital), Lucknow, India, 1997-1998
Pathology, All India Institute of Medical Sciences, New Delhi, India, 1999-2001
Senior Resident, Pathology, All India Institute of Medical Sciences, New Delhi, India, 2002-2005
Resident, Pathology, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, USA, 2007-2010
Chief Resident, Department of Pathology and Lab Medicine, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, 2009-2010
Fellow, Selective Breast Pathology, University of Texas- MD Anderson Cancer Center, Houston, Texas, USA, 2010-2011

Awards and Honors

Honors in Anatomy and Biochemistry in First MBBS examination, 1994
Honors in Pathology and Pharmacology in Second MBBS examination, 1996
Honors in Surgery and Orthopedics in Final MBBS examination, 1997
16th position, MD entrance examination, All India Institute of Medical Sciences, India, 1999
2nd Prize, Telepathology Quiz, Annual Conference of Indian Association of Pathologists and Microbiologists, Kolkata, India, 2002
1st Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
2nd Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
Donald West King Fellowship in Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, D.C., 2009
Pathology Faculty Recognition Award for Exceptional Teaching in Pathology, Mount Sinai Medical Center, NY, 2013
Listed in top abstracts in Anatomic Pathology by College of American Pathologists(CAP). Hanna MG, Jaffer S, Bleiweiss IJ, Nayak A. Re-evaluating the role of sentinel lymph node biopsy in microinvasive breast carcinoma. Mod Pathol. 2014;27(11):1489-98, 2015

Memberships and Professional Organizations

Medical Council of India (MCI), 1999 - Present
American Society of Clinical Pathology (ASCP), 2007 - 2010
College of American Pathologists (CAP), 2007 - 2010
United States and Canadian Academy of Pathology (USCAP), 2012 - Present
New York Path Society (NYSP), 2013 - 2016
American Society of Breast Diseases (ASBD), 2013 - 2015
International Society of Breast Pathologists, 2017 - Present
Pennsylvania Association of Pathologists, 2019 - Present
Pathology Society of Philadelphia, 2019 - Present

Web Links

Selected Publications

Immature natural killer cells promote progression of triple-negative breast cancer.

Thacker G, Henry S, Nandi A, Debnath R, Singh S, Nayak A, Susnik B, Boone MM, Zhang Q, Kesmodel SB, Gumber S, Das GM, Kambayashi T, Dos Santos CO, Chakrabarti R., Sci Transl Med 15(686): , 2023, PMID:36888695

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PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer

Adam A Kraya, Kara N Maxwell, Monika A Eiva, Bradley Wubbenhorst, John Pluta, Michael Feldman, Anupma Nayak, Daniel J Powell Jr, Susan M Domchek, Robert H Vonderheide, Katherine L Nathanson, JCO Precis Oncol, 2023, PMID:35201851

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Clinicopathologic Predictors of Clinical Outcomes in Mammary Adenoid Cystic Carcinoma: A Multi-institutional Study.

Khoury T, Rosa M, Nayak A, Karabakhtsian R, Fadare O, Li Z, Turner B, Fang Y, Kumarapeli A, Li X, Numbere N, Villatoro T, Wang JG, Sadeghi S, Attwood K, George A, Bhargava R., Modern Pathology 36(2): , 2023, PMID:36853781

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Biallelic BRCA loss and homologous recombination deficiency in non-breast/ovarian tumors in germline BRCA1/2 carriers

Kara Maxwell, et al., JCO Precision Oncology, 2023

Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers.

Shah JB, Pueschl D, Wubbenhorst B, Fan M, Pluta J, D'Andrea K, Hubert AP, Shilan JS, Zhou W, Kraya AA, Llop Guevara A, Ruan C, Serra V, Balmaña J, Feldman M, Morin PJ, Nayak A, Maxwell KN, Domchek SM, Nathanson KL., Nat Commun. 13(1): , 2022, PMID:36344544

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Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer

Ajeya Nandi, Rahul Debnath, Anupma Nayak, Tsun Ki Jerrick To, Gatha Thacker, Megan Reilly, Sanjeev Gumber, Ilias Karagounis, Ning Li, Christopher J Lengner, Malay Haldar, Alana L Welm, Andres M Blanco, Christoforos Thomas, Rumela Chakrabarti, Cancer Res 82(20): 3718-3733, 2022, PMID:36007109

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Subcategorization of T1 Bladder Cancer on Biopsy and Transurethral Resection Specimens for Predicting Progression

Anna Budina, Sahar J Farahani, Priti Lal, Anupma Nayak, Arch Pathol Lab Medicine 146(9): 1131-1139, 2022, PMID:34871364

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Preoperative Use of a Radiation Boost to Enhance Effectiveness of Immune Checkpoint Blockade Therapy in Operable Breast Cancer

Emily A Verbus, Alexander J Rossi, Amy S Clark, Neil K Taunk, Anupma Nayak, Jonathan M Hernandez, Julia C Tchou, Ann Surg Oncol 29(3): 1530-1532, 2022, PMID:34783947

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PTGES3 is a Putative Prognostic Marker in Breast Cancer

Adeseye Adekeye, Divyansh Agarwal, Anupma Nayak, Julia Tchou, J Surg Res 271(): 154-162, 2022, PMID:34920330

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A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers

Sarkis Hamalian, Robert Güth, Farhana Runa, Francesca Sanchez, Eric Vickers, Megan Agajanian, Justin Molnar, Tuan Nguyen, Joshua Gamez, Jonathan D Humphries, Anupma Nayak, Martin J Humphries, Julia Tchou, Ioannis K Zervantonakis, Jonathan A Kelber, Oncogene, 2021, PMID:34239043

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