Anupma Nayak, MBBS, MD
Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of PennsylvaniaPerelman School of Medicine at the University of Pennsylvania
Contact InformationHospital of the University of Pennsylvania
6 Founders Building
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.4899
Email: anupma.nayak@pennmedicine.upenn.edu
Specialty Division
Anatomic Pathology
Research Expertise
Breast Cancer
Itmat Expertise
Breast Cancer
Clinical Expertise
Breast Pathology
Education
MBBS (Medicine), King George Medical College, Lucknow, India, 1997
Specialty Certification
Anatomic Pathology, American Board of Pathology, 2010
Postgraduate Training
Intern, Dr. Shyama Prasad Mukherjee Hospital (Civil Hospital), Lucknow, India, 1997-1998
Pathology, All India Institute of Medical Sciences, New Delhi, India, 1999-2001
Senior Resident, Pathology, All India Institute of Medical Sciences, New Delhi, India, 2002-2005
Resident, Pathology, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, USA, 2007-2010
Chief Resident, Department of Pathology and Lab Medicine, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, 2009-2010
Fellow, Selective Breast Pathology, University of Texas- MD Anderson Cancer Center, Houston, Texas, USA, 2010-2011
Awards and Honors
Honors in Anatomy and Biochemistry in First MBBS examination, 1994
Honors in Pathology and Pharmacology in Second MBBS examination, 1996
Honors in Surgery and Orthopedics in Final MBBS examination, 1997
2nd Prize, Telepathology Quiz, Annual Conference of Indian Association of Pathologists and Microbiologists, Kolkata, India, 2002
1st Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
2nd Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
Donald West King Fellowship in Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, D.C., 2009
Pathology Faculty Recognition Award for Exceptional Teaching in Pathology, Mount Sinai Medical Center, NY, 2013
Listed in top abstracts in Anatomic Pathology by College of American Pathologists(CAP). Hanna MG, Jaffer S, Bleiweiss IJ, Nayak A. Re-evaluating the role of sentinel lymph node biopsy in microinvasive breast carcinoma. Mod Pathol. 2014;27(11):1489-98, 2015
AAPath (Association of Academic Pathology) Pathology Leadership Fellow (APLF), 2024
Memberships and Professional Organizations
Medical Council of India (MCI), 1999 - Present
American Society of Clinical Pathology (ASCP), 2007 - 2010
College of American Pathologists (CAP), 2007 - 2010
United States and Canadian Academy of Pathology (USCAP), 2012 - Present
American Society of Breast Diseases (ASBD), 2013 - 2015
New York Path Society (NYSP), 2013 - 2016
International Society of Breast Pathologists, 2017 - Present
Pennsylvania Association of Pathologists, 2019 - Present
Pathology Society of Philadelphia, 2019 - Present
National Mesothelioma Virtual Bank (NMVB) Steering Committee, 2023 - Present
ISPY2 Pathology Working Group, 2023 - Present
Web Links
Selected Publications
Validation Study of the Newly Proposed Refined Diagnostic Criteria for Malignant Phyllodes Tumor With 136 Borderline and Malignant Phyllodes Tumor Cases
Li X, Nguyen TTA, Zhang J, Nayak A, Liu Y, Duckworth LA, Zhang G, Bakkar R, Agarwal I, Hou Y, Guo H, Huang X, Wei S, Yasmeen S, Thaer K, Huang H, Zhang H, Smith GH, Turashvili G, Peng L, Liu Y, Yang W, Siziopikou KP., Am J Surg Pathol 48(9): 1146-1153, 2024, PMID:38934254
Change in Biomarker Profile after neoadjuvant chemotherapy is prognostic and is especially common in patients with HER2+ breast cancer.
Tchou J, Gottipati S, Goldbach M, Baxter M, Venters S, Chen Y, Gonzalves D, Ahmad Z, Nayak A, Mukhtar R, Boughey J., Annals of Surgical Oncology, 2024, PMID:39117925
Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers.
Boruah N, Hoyos D, Moses R, Hausler R, Desai H, Le AN, Good M, Kelly G, Raghavakaimal A, Tayeb M, Narasimhamurthy M, Doucette A, Gabriel P, Feldman MJ, Park J, de Rodas ML, Schalper KA, Goldfarb SB, Nayak A, Levine AJ, Greenbaum BD, Maxwell KN., bioRxiv [Preprint]., 2024, PMID:38617260
MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases.
Ito K, Harada I, Martinez C, Sato K, Lee E, Port E, Byerly JH, Nayak A, Tripathi E, Zhu J, Irie HY., Cancer Res Commun. 28(4): 946-957, 2024, PMID:38457262
Biallelic BRCA loss and homologous recombination deficiency in non-breast/ovarian tumors in germline BRCA1/2 carriers
Wineland D, Le AN, Hausler R, Kelly G, Barrett E, Desai H, Wubbenhorst B, Pluta J, Bastian P, Symecko H, D'Andrea K, Doucette A, Gabriel P, Reiss KA, Nayak A, Feldman M, Domchek SM, Nathanson KL, Maxwell KN; Regeneron Genetics Center; Penn Medicine Biobank., JCO Precision Oncology, 2023, PMID:37535879
Immature natural killer cells promote progression of triple-negative breast cancer.
Thacker G, Henry S, Nandi A, Debnath R, Singh S, Nayak A, Susnik B, Boone MM, Zhang Q, Kesmodel SB, Gumber S, Das GM, Kambayashi T, Dos Santos CO, Chakrabarti R., Sci Transl Med 15(686): , 2023, PMID:36888695
PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for Immunogenicity in BRCA-Deficient Ovarian Cancer
Adam A Kraya, Kara N Maxwell, Monika A Eiva, Bradley Wubbenhorst, John Pluta, Michael Feldman, Anupma Nayak, Daniel J Powell Jr, Susan M Domchek, Robert H Vonderheide, Katherine L Nathanson, JCO Precis Oncol, 2023, PMID:35201851
Clinicopathologic Predictors of Clinical Outcomes in Mammary Adenoid Cystic Carcinoma: A Multi-institutional Study.
Khoury T, Rosa M, Nayak A, Karabakhtsian R, Fadare O, Li Z, Turner B, Fang Y, Kumarapeli A, Li X, Numbere N, Villatoro T, Wang JG, Sadeghi S, Attwood K, George A, Bhargava R., Modern Pathology 36(2): , 2023, PMID:36853781
Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers.
Shah JB, Pueschl D, Wubbenhorst B, Fan M, Pluta J, D'Andrea K, Hubert AP, Shilan JS, Zhou W, Kraya AA, Llop Guevara A, Ruan C, Serra V, Balmaña J, Feldman M, Morin PJ, Nayak A, Maxwell KN, Domchek SM, Nathanson KL., Nat Commun. 13(1): , 2022, PMID:36344544
Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer
Ajeya Nandi, Rahul Debnath, Anupma Nayak, Tsun Ki Jerrick To, Gatha Thacker, Megan Reilly, Sanjeev Gumber, Ilias Karagounis, Ning Li, Christopher J Lengner, Malay Haldar, Alana L Welm, Andres M Blanco, Christoforos Thomas, Rumela Chakrabarti, Cancer Res 82(20): 3718-3733, 2022, PMID:36007109
