Anupma Nayak, MBBS, MD
Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Associate Vice Chair for Translational and Clinical Research
​Department of Pathology and Laboratory Medicine
Contact InformationHospital of the University of Pennsylvania
6 Founders Building
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.4899
Email: anupma.nayak@pennmedicine.upenn.edu
Specialty Division
Anatomic Pathology
Research Expertise
Breast Cancer
Itmat Expertise
Breast Cancer
Clinical Expertise
Breast Pathology
Education
MBBS (Medicine), King George Medical College, Lucknow, India, 1997
Specialty Certification
Anatomic Pathology, American Board of Pathology, 2010
Postgraduate Training
Intern, Dr. Shyama Prasad Mukherjee Hospital (Civil Hospital), Lucknow, India, 1997-1998
Pathology, All India Institute of Medical Sciences, New Delhi, India, 1999-2001
Senior Resident, Pathology, All India Institute of Medical Sciences, New Delhi, India, 2002-2005
Resident, Pathology, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, USA, 2007-2010
Chief Resident, Department of Pathology and Lab Medicine, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, NY, 2009-2010
Fellow, Selective Breast Pathology, University of Texas- MD Anderson Cancer Center, Houston, Texas, USA, 2010-2011
Awards and Honors
Honors in Anatomy and Biochemistry in First MBBS examination, 1994
Honors in Pathology and Pharmacology in Second MBBS examination, 1996
Honors in Surgery and Orthopedics in Final MBBS examination, 1997
2nd Prize, Telepathology Quiz, Annual Conference of Indian Association of Pathologists and Microbiologists, Kolkata, India, 2002
1st Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
2nd Prize, 43rd Annual Academic Competition, NSLIJHS-Albert Einstein College of Medicine at Long Island Jewish Medical Center, New York, 2008
Donald West King Fellowship in Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, D.C., 2009
Pathology Faculty Recognition Award for Exceptional Teaching in Pathology, Mount Sinai Medical Center, NY, 2013
Listed in top abstracts in Anatomic Pathology by College of American Pathologists(CAP). Hanna MG, Jaffer S, Bleiweiss IJ, Nayak A. Re-evaluating the role of sentinel lymph node biopsy in microinvasive breast carcinoma. Mod Pathol. 2014;27(11):1489-98, 2015
AAPath (Association of Academic Pathology) Pathology Leadership Fellow (APLF), 2024
Memberships and Professional Organizations
Medical Council of India (MCI), 1999 - Present
College of American Pathologists (CAP), 2007 - 2010
American Society of Clinical Pathology (ASCP), 2007 - 2010
United States and Canadian Academy of Pathology (USCAP), 2012 - Present
American Society of Breast Diseases (ASBD), 2013 - 2015
New York Path Society (NYSP), 2013 - 2016
International Society of Breast Pathologists, 2017 - Present
Pennsylvania Association of Pathologists, 2019 - Present
Pathology Society of Philadelphia, 2019 - Present
ISPY2 Pathology Working Group, 2023 - Present
National Mesothelioma Virtual Bank (NMVB) Steering Committee, 2023 - Present
Web Links
Selected Publications
An Agreement Study of Stromal Cellularity and Stromal Cell Atypia, and Tumor Border of Phyllodes Tumors of the Breast
Li X, Haw Y, Liu Y, Iqbal J, Ahmed SS, Guo H, Wei S, Yasmeen S, Ye J, Hou Y, Eshraghi R, Zhang H, Ai D, Zhang G, Nayak A, Jalali Farahani S, Rosa M, Zhan H, Buttars P, Bakkar R, Schnitt S, Brogi E, Allison K, Collins LC, Sahin A, Siziopikou KP, Chen YY, Khoury T., Mod Pathol. 39((11)): Epub ahead of print., 2026, PMID:42705611
High-Grade Urothelial Carcinoma with Divergent Prostatic Differentiation Mimicking a Collision Tumor in a Bladder Diverticulum.
Budina A, Vergara N, Navarro FE, Morrissette JJD, Nayak A., Int J Surg Pathol. 34(6): 1570-1578, 2026, PMID:41918088
Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers.
Boruah N, Hoyos D, Moses R, Hausler R, Desai H, Le AN, Good M, Kelly G, Raghavakaimal A, Tayeb M, Narasimhamurthy M, Doucette A, Gabriel P, Feldman MJ, Park J, Lopez de Rodas M, Schalper KA, Goldfarb SB, Nayak A, Levine AJ, Greenbaum BD, Maxwell KN., Nat Commun. 17(1): 7300, 2026, PMID:42168203
Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy.
Sreekumar A, Blankemeyer E, Sterner CJ, Pan TC, Pant DK, Acolatse S, Turkistani H, Belka GK, Nayak A, Carlin SD, Assenmacher CA, Sellmyer MA, Mankoff DA, Chodosh LA., Cancer Discov. 16(4): 781-799, 2026, PMID:41370830
Comparative analysis of distinct genomic landscapes in young-onset gBRCA1/2 breast cancer.
Akamandisa MP, Xia M, Cheah W, Wubbenhorst B, D'Andrea KP, Fan M, Shilan JS, Pueschl D, Nayak A, McKenzie H, Tapper W, Copson ER, Cutress RI, Domchek SM, Eccles DM, Nathanson KL., JCI Insight 11(12): e203005., 2026, PMID:42048167
Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues.
Yuan M, Jin K, Yan H, Schroeder A, Luo C, Yao S, Dumoulin B, Levinsohn J, Luo T, Clemenceau JR, Jang I, Kim M, Liu Y, Deng M, Furth EE, Wilson P, Nayak A, Lubo I, Solis Soto LM, Wang L, Park JH, Susztak K, Hwang TH, Li M., Nat Cell Biol. 27(12): 2225-2238, 2025, PMID:41298871
Targeting Dormant Tumor Cells to Prevent Recurrent Breast Cancer: a randomized phase 2 trial.
DeMichele A, Clark A, Shea E, Bayne L, Sterner C, Rohn K, Eberle-Dwyer S, Pan T-C, Nivar I, Chen Y, Wileyto EP, Berry L, DeLuca S, Savage J, Makhlin I, Pant D, Egunsola A, Mears N, Goodspeed B, Chislock E, Graves J, Wang J, Shih N, Belka G, Berry D, Nayak A, Feldman M, Martin H, Chodosh L., Nature Medicine 31(10): 3464-3474, 2025, PMID:40897974
miRNA Panel from HER2+ and CD24+ Plasma Extracellular Vesicle Subpopulations as Biomarkers of Early-stage Breast Cancer
Griffin B. Spychalski1, Andrew A. Lin, Stephanie J. Yang, Hanfei Shen, Jean Rosario, Kyle Tien, Kate French, Miriyam Ghali, Stephanie Yee, Melinda Yin, Michael D. Feldman, Emily F. Conant, Susan P. Weinstein, Erica L. Carpenter, David Issadore, Anupma Nayak, Breast Cancer Res. 27(1): 90, 2025, PMID:40405296
Clinicopathologic Features of Breast Tumors in Germline TP53 Variant-Associated Li-Fraumeni Syndrome.
Narasimhamurthy M, Le A, Boruah N, Moses R, Kelly G, Bleiweiss I, Maxwell KN, Nayak A., Am J Surg Pathol. 49(3): 195-205, 2025, PMID:39629784
Pathogenic Germline Variants in Patients with Metaplastic Breast Cancer
Kaitlin Demarest, Arravinth Anantharajah, Kara N. Maxwell1, Mersedeh Rohanizadegan, Angela Bradbury, Katherine L Nathanson, Susan Domchek, Anupma Nayak, Payal D. Shah, JAMA Network Open 8(2): e2460312, 2025, PMID:39964682
