PEOPLE

Elizabeth M. Margolskee, MD, MPH

Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Contact Information3401 Civic Center Boulevard
Philadelphia, PA, 19104
Office: 6316808643

Specialty Division

Hematopathology

Other Expertise

On my first day as a lab director, I learned that our entire dayshift staff had been exposed to COVID-19 in the workplace and had to quarantine. Although no one became seriously ill, this experience framed my relationship with laboratory professionals, and highlighted their role as front line workers.

I work closely with Surabhi Mulchandani, Vice Chair for Laboratory Administration, and other leadership in the department, to develop sustainable, ongoing strategies to develop and strengthen the pathology workforce.

Clinical Expertise

I am a hematopathologist and Director of the hematology laboratory at Children's Hospital of Philadelphia. I came to hematopathology originally because I wanted to care for critically ill patients alongside intelligent, curious clinicians in a collaborative fashion. I also enjoy interacting with our strong flow cytometrists, medical technologists, molecular pathologists, cytogeneticists, histotechs and pathology assistants, who make my work possible.

I am interested in quality and process improvement in the lab, and I am particularly fascinated by pediatric myeloid neoplasms.

Education

AB Harvard University, Cambridge, MA, 2006
MD Mount Sinai School of Medicine, New York, NY, 2010
MPH (Epidemiology), Columbia University Mailman School of Public Health, 2014

Specialty Certification

American Board of Pathology, Anatomic and Clinical Pathology, 2015
American Board of Pathology, Hematopathology, 2016

Postgraduate Training

Resident, Anatomic/Clinical Pathology, NYPH-Columbia University Medical Center, New York, NY, 2010-2015
Chief Resident, Anatomic/Clinical Pathology NYPH-Columbia University Medical Center, New York, NY, 2012-2013
Fellow, Hematopathology, NYPH-Weill Cornell, New York, NY, 2015-2016

Awards and Honors

Vermeule Prize for excellence in Archaeological Scholarship, 2006
Hoopes Prize for Senior thesis, 2006
Honorable Mention: Gold Foundation Humanism in Medicine Essay Contest, 2009
Wyman Scholar at Mailman School of Public Health, 2013
American Society of Hematology Abstract Achievement Award, 2013
American Society of Hematology Abstract Achievement Award, 2015
Best Podium Presentation, 8th Annual CHOP Education Day, 2025

Memberships and Professional Organizations

United States & Canadian Academy of Pathology, 2012 - Present
College of American Pathologists, 2016 - Present
AIDS Malignancies Consortium, 2017 - 2019
Society for Hematopathology, 2018 - Present
American Society for Clinical Pathology, 2022 - Present

Web Links


Selected Publications

Addressing patient safety and interprofessional communication through the implementation of a Challenging Interactions reporting tool in a clinical laboratory

Chandan Kular, Kenneth Smith, Kara Thompson, Elizabeth Margolskee, CHOP Employee Well-being Summit, 2025

Enhanced Interprofessional Communication Between Nurses and Laboratory Scientists Reduces Specimen Cancellation Rate

Caitlyn Musick, Grace McGrath, Megan McAuley, Elizabeth Margolskee, CHOP Education Day, 2025

Clinical, Immunophenotypic, and Genomic Findings of Acute Myeloid Leukemia with RAM Immunophenotype: Comparison with Other CD56-positive Acute Leukemias

Hamdan H, Liu Y, Wang SA, Bledsoe J, Chisholm KM, Siddon A, Ohgami R, George TI, Kurzer J, Hasserjian RP, Arber DA, Bagg A, Foucar K, Margolskee E, Laczko D, Chen W, Fuda F, Aggarwal N, Weinberg OK, eJHaem, 2024

Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays

Kim D, Margolskee E, Goyal A, Siddiqui MT, Heymann JJ, Rao R, Hayden J, J Clin Pathol, 2023, PMID:37940376

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Transdifferentiation of B-lymphoblastic Leukemia to Histiocytic Sarcoma After Immunotherapy

Fenu EM, Margolskee E, Pillai V, American Journal of Hematology 98(8): E216-E218, 2023, PMID:37259821

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Optimizing ISLH lymphocytosis and monocytosis thresholds for manual differential smear review in the pediatric setting

Dana Martin, Megan Zoltowski, Emily Williams, Elizabeth Margolskee, IJLH 45(): 76, 2023

2023 Digital Slide Program in Hematopathology: Case 6: Juvenile Myelomonocytic Leukemia (JMML).

Margolskee E., College of American Pathologists (CAP) Hematopathology Committee., 2023

Quantification of Neutrophil Extracellular Traps (NETs) in Pediatric Patients with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) through Plasma and Peripheral Smear Analysis

Thompson R, Zoltowski M, Lim D, Diorio C, Margolskee M, Paessler M, Bochenek V, Behrens EM, Teachey DT, Massiri H, Lambert MP, Gollomp K, American Society of Hematopathology 64th Annual Meeting, New Orleans, 2022

Haematology Laboratory Parameters to Assess Efficacy of CD19-, CD22-, CD33-, and CD123-directed Chimeric Antigen Receptor T-cell Therapy in Haematological Malignancies

Drumheller B, Gebre K, Lockhart B, Margolskee E, Obstfeld A, Paessler M, Pillai V, International Journal of Laboratory Hematology 44(4): 750-758, 2022, PMID:35419923

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Improving STAT CBCDI Turnaround Times

Whitener V, Barry D, Helfrich M, Forman J, Zoltowski M, Lim D, Williams E, Shah V, Margolskee B, Bidegary A, CHOP Quality Improvement and Patient Safety Day, 2022