The newly established Center for Artificial Intelligence and Data Science for Integrated Diagnostics (AI2D) in the Perelman School of Medicine, is directed by Christos Davatzikos, PhD (Department of Radiology) and Li-San Wang, PhD (Department of Pathology and Laboratory Medicine). The AI2D is a highly collaborative effort led by faculty in several PSOM departments, with focus on AI-driven integrated diagnostics, and was seeded by the emerging Integrated Diagnostics Program co-led by the Department of Radiology and the Department of Pathology and Laboratory Medicine. The center will catalyze the use of advanced, but domain-specific AI and data science methods to leverage complex and large datasets, especially data produced by various laboratory tests offered by the Departments of Radiology and Pathology and Laboratory Medicine, eventually leading to a new generation of “in silico biomarkers” and personalized diagnostic and predictive models. The Center’s activities will dovetail with work in Pathology and Laboratory Medicine’s new Division of Diagnostic Innovation, as well as with translational AI work in both departments.