Wayne William Hancock, MB.BS, PhD, FRCPA
Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information916B Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: 215-590-8709
Fax: 215-590-7384
Email: whancock@pennmedicine.upenn.edu
Specialty Division
Cancer and Immunobiology
Research Expertise
Research Interests
Transplant immunobiology, inflammation and mechanisms of disease, Treg cells, cancer immunology, therapeutics
Research Summary
New Co-Stimulation Molecules And Their Function In Vivo
The world is currently awash with costimulation molecules. Individual labs tout this or that molecule as being key to T cell activation under specific (often ludicrously specific) conditions, but none of these "insights" have yet led to actual therapeutic agents in clinical use. This reflects several factors. Drug companies make drugs and then try and find an application for them, ideally rheumatoid arthritis, multiple sclerosis, asthma or some other widespread disease involving long-term therapy, but certainly not any of the indications subject to the "too small a market (e.g.
CVI Expertise
CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Myocyte Biology / Heart Failure
Biotechnology / Nanomedicine / Imaging
Thrombosis / Hemostasis
CVI Research Description:
I am interested in immunologic and inflammatory events affecting the cardiovascular system, with particular interest in replacement therapies, whether by manipulation of stem cells or through cardiac transplantation. Optimizing outcomes of cardiac transplantation is another special interest.
Itmat Expertise
Transplantation
Autoimmunity
Tolerance
Epigenetics
Therapeutics
HDAC inhibitors
HAT inhibitors
DNMT inhibitors
Graduate Groups
Immunology
Education
M.B.B.S. (Medicine), Monash University, Clayton, Victoria, Australia, 1977
Ph.D. (Medicine), Monash University, Clayton, Victoria, Australia, 1984
F.R.C.P.A. (Pathology), Royal College of Pathologists of Australasia, 1989
Specialty Certification
Fellow of the Royal College of Pathologists of Australasia, 1989
Postgraduate Training
Intern in Medicine , Alfred Hospital, Mebourne, Australia, 1977-1978
Resident in Medicine, Alfred Hospital , Mebourne, Australia, 1978-1979
Pathology Fellow , Prince Henry's Hospital, Melbourne, Australia, 1980-1983
Research Fellowship, Pathology, Brigham and Women's Hospital, Boston, MA, 1984-1986
Awards and Honors
Australian Kidney Foundation Medical Research Scholarship, 1981
Neil Hamilton Fairley Fellowship, National Health and Medical Research Council of Australia, 1984-1985
Australasian Society of Nephrology Travelling Fellowship, 1984
Fogarty International Research Fellowship (NIH), 1985
Inaugural NIH Basic Science Award for Best Basic Science Abstract, American Society for Transplant Physicians, 1996
Memberships and Professional Organizations
The Transplantation Society, 1983 - Present
International Society of Nephrology, 1983 - Present
American Society of Nephrology, 1984 - Present
The Histochemical Society, 1985 - 1994
American Association of Immunologists, 1986 - Present
Transplantation Society of Australia and New Zealand, 1990 - present
American Society of Transplant Physicians, 1993 - 2001
American Society of Transplant Physicians, 1993 - 2001
American Society for Investigative Pathology, 1994 - 2004
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 1995 - 2003
American Society for Hematology, 1997 - Present
National Kidney Foundation, 1997 - 2001
American Society of Transplantation, 2001 - Present
NIH Surgery, Anesthesiology and Trauma (SAT) Study Section, 2003 - 2004
NIH Transplantation, Tolerance & Tumors (TTT) Study Section, 2004 - 2006
National Institutes of Health, 2007 - 2007
British Heart Foundation, 2007 - 2007
National Health and Medical Research Council of Australia, 2008 - 2008
National Institutes of Health, 2008 - 2008
Wessex Medical Research, 2008 - 2008
National Institutes of Health, 2008 - 2008
The Wellcome Trust, 2008 - 2009
University of Pennsylvania, 2008 - Present
International Pancreas and Islet Transplant Association, 2009 - Present
National Institutes of Health, 2009 - 2009
Australian National University, 2009 - 2010
National Institutes of Health, 2009 - 2009
National Institutes of Health, 2010 - 2010
National Institutes of Health, 2010 - 2010
Australian National University, 2010 - 2010
Swiss National Science Foundation, 2010 - 2010
Arthritis Research UK, 2010 - 2010
American Association for Cancer Research, 2011 - Present
Transplant Research Foundation of British Columbia, Canada, 2011 - 2011
National Institutes of Health, 2011 - 2011
American Society for Microbiology, 2011 - Present
American Chemical Society, 2011 - Present
National Institutes of health, 2011 - 2011
National Institutes of Health, 2012 - 2012
National Institutes of Health, 2012 - 2012
National Institutes of Health, 2012 - 2019
Broad Medical Research Program, 2012 - 2012
Austrian Science Fund, 2013 - 2013
Leukaemia & Lymphoma Research, 2013 - 2013
National Institutes of Health, 2013 - 2013
Children's Hospital of Philadelphia, 2013 - 2013
Medical Research Council (UK), 2013 - 2013
Department of Defense, 2013 - 2013
National Institutes of Health, 2013 - 2013
National Institutes of Health, 2013 - 2014
National Institutes of Health, 2014 - 2014
Department of Defense, 2014 - 2014
National Institutes of Health, 2014 - 2014
International Hand and Composite Tissue Allotransplantation Society, 2014 - present
Israel Science Foundation, 2014 - 2014
National Institutes off Health, 2015 - 2015
National Institutes of Health, 2015 - 2015
National Institutes of Heath, 2016 - 2016
National Institutes of Health, 2016 - 2016
Veterans Administration, 2016 - 2016
National Institutes of Health, 2016 - 2016
National Institutes of Health, 2016 - 2016
National Institutes of Health, 2017 - 2017
Children's Hospital of Philadelphia, 2017 - 2017
National Institute so fHealth, 2017 - 2017
National Institutes of Health, 2017 - 2017
Trisomy 21 Research Society, 2017 - present
American Society for Biochemistry and Molecular Biology, 2017 - present
International Chemical Biology Society, 2017 - Present
Society for Immunotherapy of Cancer, 2017 - Present
American Thoracic Society, 2017 - present
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
Oligonucleotide Therapeutics Society, 2018 - present
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2018 - 2018
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
American Society of Gene & Cell Therapy, 2019 - present
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2019 - 2019
National Institutes of Health, 2020 - 2020
National Institutes of Health, 2020 - 2020
Web Links
Selected Publications
Differential effects of HDAC6 inhibition versus knockout during hepatic ischemia reperfusion injury highlight importance of HDAC6 C-terminal zinc-finger ubiquitin-binding domain.
Concors SJ, Hernandez PT, O’Brien C, DePaolo J, Murken DR, Aufhauser DD, Wang Z, Xiong Y, Krumeich L, Ge G, Beier UH, Bhatti TR, Kozikowski AP, Avelar L, Kurz T, Hancock WW, Levine MH., Transplantation, 2024
Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity.
Akimova T, Wang L, Bartosh Z, Christensen L, Eruslanov E, Singhal S, Aishwarya V, Hancock WW., Frontiers in Immunology 15(): 1426657, 2024
T-regulatory cells require Sin3a for stable expression of Foxp3.
Christensen LM, Akimova T, Wang L, Han R, Samanta A, Di Giorgio E, Hancock WW., Frontiers in Immunology 15(): 1444937, 2024
Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
Thomas RM, Pahl MC, Wang L, Grant SFA, Hancock WW, Wells AD., eLife, 2024
Advancing mouse models for transplantation research.
Cravedi P, Riella LV, Ford M, Valujskikh A, Menon MC, Kirk AD, Alegre ML, Feng S, Kehn P, Najafian N, Hancock W, Heeger PS, Maltzman J, Mannon RB, Nadig S, Odim J, Turnquist H, Shaw J, West L, Luo X, Chong A, Bromberg J, on behalf of the AST COTS MOuse MOdels in Transplantation (MOMOT) work group., American Journal of Transplantation, 2024
FOXP3+ regulatory T cells are associated with the severity and prognosis of sarcoidosis.
Patterson KC, Miller WT, Hancock WW, Akimova T., Frontiers in Immunology 14(): 1301991, 2023
Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition.
Lax E, Do Carmo S, Enuka Y, Sapozhnikov DM, Welikovitch LA, Mahmood N, Rabbani SA, Wang L, Britt JP, Hancock WW, Yarden Y, Szyf M., Translational Psychiatry 13(): 259, 2023
The selective estrogen receptor modulator, Raloxifene, is protective against renal ischemia reperfusion injury.
Hernandez P, O’Brien C, Concors SJ, Wang Z, Ge G, Hancock WW, Levine MH., Transplantation 106(): 2166-2171, 2022
Clinically available immunosuppression with tacrolimus combined with basiliximab, rapamycin and CTLA4Ig averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques.
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Balamurugan AN, Bansal-Pakala P, Murtaugh MP, O’Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ., American Journal of Transplantation 22(): 745-760, 2022
Clinically available immunosuppression with tacrolimus combined with basiliximab, rapamycin and CTLA4Ig averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques.
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Balamurugan AN, Bansal-Pakala P, Murtaugh MP, O’Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ., American Journal of Transplantation 22(): 745-760, 2022
