Malek Kamoun, MD, PhD
Professor of Pathology and Laboratory Medicine at the
Hospital of the University of Pennsylvania
Director, Clinical Immunology and Histocompatibility Laboratory
Perelman School of Medicine at the University of Pennsylvania
Contact InformationHospital of the University of Pennsylvania
7.020 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104-4238
Tel: 215-614-1902
Fax: 215-349-5090
Email: malekkam@pennmedicine.upenn.edu
Specialty Division
Laboratory Medicine
Research Expertise
Research Interests: HLA genes and molecules in clinical transplantation
Keywords: Human immunogenetics, HLA genes and molecules. Clinical Histocompatibility, clinical transplantation, autoimmunity.
Research Summary:
Dr. Kamoun's research interest is to define the extent and nature of HLA haplotype genetic diversity and to understand the biological relevance of amino acid polymorphism in HLA class I and class II molecules. Computational and biostatical methods are used to evaluate the significance of HLA amino acid polymorphism in clinical transplantation and autoimmunity.
Another interest is to better understand the impact of B cell alloresponse and anti-HLA antibodies on allograft outcomes in clinical transplantation including islet cell transplantation. Clinical trials are used to assess the effectiveness of B cell depleting agents on alloantibody levels and allograft survival in transplant recipients.
Clinical Expertise
Clinical laboratory immunology: Diagnostic tests used in the evaluation of autoimmune diseases, infectious diseases, and immune deficiencies.
Clinical histocompatibility testing: HLA genotyping and HLA antibody testing used for the evaluation of solid organ and allogeneic bone marrow/hematopoietic cell transplantion and donor selection.
Graduate Groups
Immunology
Education
Pre-Med Université de Strasbourg (France), 1970
MD Université de Pierre et Marie Curie (Paris, France), 1977
PhD (Immunogenetics), Université de Pierre et Marie Curie (Paris, France), 1977
Specialty Certification
American Board of Pathology; Clinical Pathology, 1981
American Board of Pathology; Immunopathology, 1984
Postgraduate Training
Intern, Immunohematology, Hospital Saint-Louis (Paris, France), 1975-76
Fellowship, Immunogenetics, Hospital Saint-Louis (laboratory of Jean Dausset) (Paris, France), 1976-77
Postdoctoral Research Fellow in Immunogenetics, Sloan-Kettering Institute (Laboratory of Dr. Bo Dupont), 1977-78
Associate, Medical Oncology, Fred A. Hutchinson Cancer Research Center (Seattle, WA), 1978-80
Resident, Laboratory Medicine, University of Washington, 1978-80
Fellowship, Hematopathology, Department of Laboratory Medicine, University Hospital (Seattle, WA), 1980-81
Awards and Honors
Pasteur Valery Radot Fellowship (Paris, France), 1977
New Investigator Research Award, NCI, NIH, 1981
Special Fellow Award, Leukemia Society of America, 1984
Peter C. Nowell Teaching Award, University of Pennsylvania School of Medicine, 1992
Member, John Morgan Society (Philadelphia, PA), 1998
Co-Recipient, UPHS Patient Safety and Quality Award, 2003
Co-Recipient, UPHS Patient Safety and Quality Award, 2005
Nominee, Outstanding Course Director Award, University of Pennsylvania School of Medicine, 2005
Memberships and Professional Organizations
American Society for Clinical Histocompatibility and Immunogenetics (ASHI), 1983-present
Academy of Clinical Laboratory Physicians and Scientists (ACLPS), 1987-present
American Society of Transplantation, 2002-present
United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN), 2002-present
National Kidney Registry, 2011-present
Federation of Clinical Immunology Societies, 2012-present
Immucor, 2014-present
American Society for Blood and Marrow Transplantation, 2015-present
Omixon, 2016-present
American Society for Transplantation and Cellular Therapy (ASCBMT), 2017-present
Luminex, 2019-present
The Food and Drug Administration (FDA) and The U.S. Department of Health and Human Services (HHS), -present
National Institutes of Health, -present
College of American Pathologist, -present
American Association of Pathologists, -present
American Society of Clinical Pathologists, -present
Clinical Immunology Society, -present
American Association of Immunologists, -present
Web Links
Selected Publications
HLA-A amino acid polymorphism and delayed kidney allograft function
Kamoun M, Holmes JH, Israni AK, Kearns JD, Teal V, Yang WP, Rosas SE, Joffe MM, Li H, Feldman HI, Proc Natl Acad Sci U S A 105(48): 18883-8, 2008, PMID:19033208
Organ Procurement and Transplantation Network/United Network for Organ Sharing Histocompatibility Committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients
Nikaein A, Cherikh W, Nelson K, Baker T, Leffell S, Bow L, Crowe D, Connick K, Head MA, Kamoun M, Kimball P, Klohe E, Noreen H, Rebellato L, Sell T, Sullivan K, Land G, Transplantation 87(4): 557-62, 2009, PMID:19307794
Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans
Harris RA, Sugimoto K, Kaplan DE, Ikeda F, Kamoun M, Chang KM, Hepatology 48(1): 70-9, 2008, PMID:18537178
A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): factors associated with B lymphocyte recovery
Sutter JA, Kwan-Morley J, Dunham J, Du YZ, Kamoun M, Albert D, Eisenberg RA, Luning Prak ET, Clin Immunol 126(3): 282-90, 2008, PMID:18226586
Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation
Goral S, Prak EL, Kearns J, Bloom RD, Pierce E, Doyle A, Grossman R, Naji A, Kamoun M, Nephrol Dial Transplant 23(1): 390-2, 2008, PMID:17956891
Assessment of differences in HLA-A, -B, and -DRB1 allele mismatches among African-American and non-African-American recipients of deceased kidney transplants
Kamoun M, Israni AK, Joffe MM, Hoy T, Kearns J, Mange KC, Feldman D, Goodman N, Rosas SE, Abrams JD, Brayman KL, Feldman HI, Transplant Proc 39(1): 55-63, 2007, PMID:17275474
Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity
Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A, J Clin Endocrinol Metab 92(7): 2410-4, 2007, PMID:17488791
Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library
Monos D, Heliopoulos J, Argyris E, Cordopatis P, Zompra A, Kamoun M, J Mol Recognit 19(6): 535-41, 2006, PMID:16941565
Progressive multifocal leukoencephalopathy in a patient with common variable immunodeficiency and abnormal CD8+ T-cell subset distribution
Narula S, LaRosa DF, Kamoun M, Dalmau J, Levinson AI, Ann Allergy Asthma Immunol 98(5): 483-9, 2007, PMID:17521034
2008 ACLPS panel discussion on resident education in clinical pathology
Luning Prak ET, Young DS, Kamoun M, Nachamkin I, Alexander CB, Spitalnik SL, Peerschke EI, Smith BR, Am J Clin Pathol 131(5): 618-22, 2009, PMID:19369619
