Michele E. Paessler, DO
Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information3401 Civic Center Boulevard
Suite 5199D
Philadelphia, PA 19104
Office: 267-426-7309
Fax: 215-590-2130
Email: paessler@email.chop.edu
Education
B.S. Muhlenberg College (with honors), Allentown, PA, 1993
D.O. Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 1997
Specialty Certification
Anatomic Pathology and Clinical Pathology, 2004
Hematology/Hematopathology, 2004
Molecular Genetic Pathology, 2005
Postgraduate Training
Intern in Medicine, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1997-1998
Resident in Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, 1998-2001
Chief Resident, Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, 2000-2001
Fellow, Molecular Pathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2001-2003
Fellow, Hematopathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2002-2003
Fellow, Molecular Genetic Pathology, University of Pennsylvania Medical Center, Philadelphia, PA, 2003-2004
Awards and Honors
Deans List, Muhlenberg College, Allentown, PA, 1990-1993
Philadelphia College of Osteopathic Medicine Academic Scholarship, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1994-1997
William F. Daiber, D.O. Memorial Cardiology Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1997-1997
Sigma Xi Research Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1997-1997
Internship Cardiology/Critical Care Award, Philadelphia College of Osteopathic Medicine (PCOM)/Allegheny University Hospitals, Philadelphia, PA, 1998-1998
2001 Resident Teaching Award, Dept of Pathology, University of Pennsylvania Medical Center, Philadelphia PA, 2001-2001
William Pepper Clinical Laboratory Fellow, University of Pennsylvania Medical Center, Philadelphia PA, 2001-2001
Memberships and Professional Organizations
Pennsylvania Osteopathic Medical Association, 1997 - Present
United States and Canadian Academy of Pathology, 2000 - Present
Association of Molecular Pathology, 2001 - 2004
American Society of Hematology, 2002 - Present
International Clinical Cytometry Society, 2005 - Present
Society for Pediatric Pathology, 2005 - Present
College of American Pathologists - Instrumentation Resource Committee, 2007 - Present
NAPAAC Aplastic Anemia Retrospective Analysis
Hematopathology Working Group Study, 2013 - present
Society of Hematopathology, 2015 - Present
International Society for Laboratory Hematology (ISLH), 2016 - Present
American Society of Clinical Pathology, 2022 - Present
Web Links
Selected Publications
Uncovering the Genetic Etiology of Inherited Bone Marrow Failure Syndromes Using a Custom-Designed Next-Generation Sequencing Panel
Lin F, Cao K, Chang F, Oved JH, Luo M, Fan Z, Schubert J, Wu J, Zhong Y, Gallo DJ, Denenberg EH, Chen J, Fanning EA, Lambert MP, Paessler ME, Surrey LF, Zelley K, MacFarland S, Kurre P, Olson TS, Li MM, J Mol Diagn 26(3): 191-201, 2024, PMID:38103590
Haematology laboratory parameters to assess efficacy of CD19-, CD22-, CD33-, and CD123-directed chimeric antigen receptor T-cell therapy in haematological malignancies
Drumheller B, Gebre K, Lockhart B, Margolskee E, Obstfeld A, Paessler M, Pillai V, International Journal of Laboratory Hematology 44(4): 750-758, 2022, PMID:35419923
Transcriptome and Unique Cytokine Microenvironment of Castleman Disease
Wing A, Xu J, Meng W, Rosenfeld AM, Li EY, Wertheim G, Paessler M, Bagg A, Frank D, Tn K, Teachey DT, Lim MS, Luning Prak E, Fajgenbaum DC, Pillai V, Modern Pathology 35(4): 451-461, 2022, PMID:34686774
Hematopathologic Correlates of CAR T-Cell Therapy
Dolan JG, Paessler ME, Rheingold SR, Pillai V, Clinics in Laboratory Medicine 41(3): 325-339, 2021, PMID:34304768
Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis
Si S, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE, Journal of Clinical Immunology 41(6): 1213-1218, 2021, PMID:33761058
Combined Use of Emapalumab and Ruxolitinib in a Patient with Refractory Hemophagocytic Lymphohistiocytosis was Safe and Effective
Triebwasser MP, Barrett DM, Bassiri H, Bunin N, Elgarten C, Freedman J, Geera AS, Monos D, Lambert MP, Olson T, Seif AE, Paessler M, Petrosa W, Anne F Reilly, Romberg N, Sullivan KE, Quinn GZ, Behrens E, Teachey DT, Pediatric Blood and Cancer 68(7): , 2021, PMID:33754483
Evidence of Thrombotic Microangiopathy in Children with SARS-CoV-2 Across the Spectrum of Clinical Presentations
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT, Blood Advances 23(4): 6051-6063, 2020, PMID:33290544
Multisystem Inflammatory Syndrome in Children and COVID-19 are Distinct Presentations of SARS-CoV-2
Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John AR, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H, The Journal of Clinical Investigation 130(11): 5967-5975, 2020, PMID:32730233
Diagnostic Biomarkers to Differentiate Sepsis from Cytokine Release Syndrome in Critically Ill Children
Diorio C, Shaw PA, Pequignot E, Orlenko A, Chen F, Aplenc R, Barrett DM, Bassiri H, Behrens E, DiNofia AM, Gonzalez V, Koterba N, Levine BL, Maude SL, Meyer NJ, Moore JH, Paessler M, Porter DL, Bush JL, Siegel DL, Davis MM, Zhang D, June CH, Grupp SA, Melenhorst JJ, Lacey SF, Weiss SL, Teachey DT, Blood Advances 4(20): 5174-5183, 2020, PMID:33095872
CAR T-cell Therapy is Effective for CD 19-dim B-lymphoblastic Leukemia but is Impacted by Prior Blinatumomab Therapy.
Pillai V, Muralidharan K, Meng W, Bagashev A, Oldridge DA, Rosenthal J, Van Arnam J, Melenhorst JJ, Mohan D, DiNofia AM, Luo M, Cherian S, Fromm JR, Wertheim G, Thomas-Tikhonenko A, Paessler M, June CH, Luning Prak ET, Bhoj VG, Grupp SA, Maude SL, Rheingold SR, Blood Advances 3(22): 3539-3549, 2019, PMID:31738832
