Human GPR174 Deficiency Drives Lymphoproliferation Resembling Kikuchi-Fujimoto Disease via Defects in T Cell Function

Yun-Han Huang1,2*, Kathya Arana3,4*, Hanson Tam1, Jarmila Stremenova Spegarova5, Karin R. Engelhardt5, Helen Griffin5, Molly Mee5, Maurizio Miano6, Federica Raggi 6, Alice Grossi7, Marta Rusmini8, Isabella Ceccherini7, Gianluca Dell’Orso6, Jacopo Ferro9, Vinodh Pillai,10 Siddarth Banka11,12, Tomaz Garcez13, Tracy A. Briggs12, Fethi Mellouli14, Sandra von Hardenberg15,16, Rita Beier17, Bernd Auber15, Ulrich Baumann18, Hasan Tawamie19, Edward Behrens20,21, Emylette Cruz Cabrera4, Ying Xu1, Shinyi Ouyang1, Sophie Hambleton5, Neil Romberg4,20+, Jason Cyster1+, ACR Convergence 2026, 2026

A single-cell atlas of >1 million blood and lymph node immune cells reveals peripheral and tissue immune reprogramming following CD3×CD19 T-cell engager therapy in active SLE

Jason Xu¹,²,³#, Chunli Mei²#, Xin Guan²#, Rong Du², Bin Wu⁴, Di Wu², Mengjiao Li², Jingna Li², You Song², Hua Su⁵, Xiaoqi Chen⁶, Qianyu Guo⁷, Hanyang Chen⁸, Kenan Onel⁹, Tobias V. Lanz¹⁰,¹, Tamiko R. Katsumoto¹, Xiaoqiang Yan⁸, Kai Tan¹¹,¹², Caroline Diorio¹¹,¹², David T. Teachey¹¹,¹², Vinodh Pillai¹¹,¹², Gisselle Salmasi13, Andreas Kerschbaumer¹, Eric Meffre¹, Vanessa E. Kennedy14, William H. Robinson¹, Anbing Huang², Qiubai Li²* and Matthew C. Baker¹*, ACR Convergence 2026, 2026

Multi-lineage immune remodeling following CD3xCD19 T-cell engagement in active systemic lupus erythematosus: single-cell genomic results from a Phase I investigator initiated trial

Jason Xu1,2#, Chunli Mei2#, Xin Guan2#, Rong Du2#, Bin Wu3#, Di Wu2, Mengjiao Li2, Jingna Li2, You Song2, Hua Su4, Xiaoqi Chen5, Qianyu Guo6, Hanyang Chen7, Jonathan H. Sussman8,9, Gregory M. Chen8, Shovik Bandyopadhyay8,9, Vinodh Pillai9, Michaela Liedtke10, Kai Tan8,9, Caroline Diorio8,9, David T. Teachey8,9, Tobias V. Lanz11,12, Kenan Onel13, Gisselle Salmasi14, Tamiko R. Katsumoto11, William H. Robinson11, Andreas Kerschbaumer11, Eric Meffre11, Vanessa E. Kennedy10, Xiaoqiang Yan7, Anbing Huang2, Matthew C. Baker11* and Qiubai Li2*,, ACR Convergence 2026, 2026

A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial

Xu J, Mei C, Guan X, Du R, Wu B, Wu D, Li M, Li J, Song Y, Su H, Chen X, Guo Q, Chen H, Sussman J, Chen G, Liedtke M, Tan K, Onel K, Teachey D, Lanz T, Katsumoto T, Robinson W, Meffre E, Kennedy V, Yan X, Huang A, Baker M, Bandyopadhyay S, Pillai V, Salmasi G, Nature Medicine, 2026, PMID:6400537

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How I diagnose Castleman disease

Dorottya Laczko; Vinodh Pillai; Dale Frank; Joshua D. Brandstadter; David C. Fajgenbaum, American Journal of Clinical Pathology 165(3): , 2026, PMID:41802815

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Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T-cell therapies

Carturan A, Angelos MG, Guruprasad P, Patel RP, Pajarillo R, Lee AE, Espie D, Zhang Y, Chiang YH, Xie W, Rodriguez JL, Harris J, Devi P, Afolayan-Oloye OI, Xu J, Sussman JH, Elghawy O, Yang AG, Barsouk A, Cho JH, Shaw CE, Singh EB, Ugwuanyi O, Paruzzo L, Stella FMD, Liu S, Nason S, Imparato A, Rotolo A, Lemoine J, Barrett DM, Posey AD Jr, Rook AH, Pillai V, Bagg A, Pileri SA, Liu D, Tan K, Schuster SJ, Teachey DT, Porazzi P, Ruella M, Blood, 2026, PMID:41490267

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The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

Ang Z, Castro A, Paruzzo L, Schmidt C, Hasanali ZS, Hayer KE, Stella F, Soldan SS, Torres-Diz M, Kwok C, Sainos PK, Ji K, Krohl PJ, Fine J, Sehgal P, Martinez D, Spangler JB, Riley JL, Vogl DT, Porazzi P, Pillai V, Lieberman PM, Allman D, Ruella M, Thomas-Tikhonenko A, bioRxiv, 2026, PMID:41648131

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090 – Pediatric ALK-negative anaplastic large cell lymphoma genetically differs from the adult counterpart

James ER, Salmeron-Villalobos J, Colmenero A, Frauenfeld L, Andres M, Verdu J, Garcia N, Simonitsch-Klupp I, Attarbaschi A, Bacon CM, Burke GA, Lockhart B, Ducray SP, Chen Z, Tizioni MM, Matthews JD, Steel C, Pillon M, Lussolin A, Pervez S, Pillai V, Štěrba J, Krenova Z, Aven M, Wrobel G, Werner J, Knorr F, Oschlies I, Klapper W, Woessmann W, Balague O, Salaverria I, Turner SD, Leukemia Research 156(Supplement): Abstract 090, 2025

Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways

Smith D, Eichinger A, Fennell É, Xu-Monette ZY, Rech A, Wang J, Esteva E, Seyedian A, Yang X, Zhang M, Martinez D, Tan K, Luo M, Young KJ, Murray PG, Park C, Reizis B, Pillai V, Nat Commun 16(1): 6009, 2025, PMID:40593805

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RNA-seq of seven non-neoplastic/inflammatory lymphadenitis entities identify potential molecular diagnostic markers

Julia Wang, Brian Lockhart, Jason Xu, Vinodh Pillai, bioRxiv, 2025