Gerald B. Wertheim, MD, PhD
Associate Professor of Clinical Pathology and Laboratory MedicinePerelman School of Medicine at the University of Pennsylvania
Contact InformationDepartment of Pathology and Laboratory Medicine
Children's Hospital of Philadelphia
5199B Main Building
5th Floor
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 267-970-5918
Fax: 215-590-1736
Email: wertheimg@email.chop.edu
Itmat Expertise
DNA methylation
Acute myeloid leukemia prognosis
Education
BS (Chemistry), Yale University, New Haven CT, 1994
PhD (Cancer Biology), University of Pennsylvania School of Medicine, 2004
MD (Medicine), University of Pennsylvania School of Medicine, 2005
Specialty Certification
American Board of Pathology, Anatomic and Clinical Pathology, 2009
American Board of Pathology, Hematopathology, 2011
Postgraduate Training
Resident in Anatomic and Clinical Pathology, Hospital of the University of Pennsylvania, 2005-2009
Fellowship, Hematopathology, Hospital of the University of Pennsylvania, 2009-2011
Awards and Honors
Phi Beta Kappa, Yale University, 1993
The Werner Bergmann Award in Chemistry, Yale University, 1994
summa cum laude, Yale University, 1994
21st Century/Gamble Scholarship (Full Four-Year Medical School Tuition), University of Pennsylvania School of Medicine, 1995-2005
The Stella Botelho Award in Physiology, University of Pennsylvania School of Medicine, 1996
Dolores Zohrab Liebmann Fellowship, 1997
Susan G. Komen Breast Cancer Research Fellowship, 2001-2003
Endocrinology Research Award, University of Pennsylvania School of Medicine, 2005
International Society of Laboratory Hematology; One of Top Five Abstracts at Society's International Meeting; Nice, France., 2012
Memberships and Professional Organizations
American Society of Hematology, 2015 - Present
The United States and Canadian Academy of Pathology, 2015 - Present
Society of Hematopathology, 2015 - Present
Selected Publications
Giant cytoplasmic inclusions (Alder-Reilly bodies) in Hurler syndrome (mucopolysaccharidosis type 1H)
Shah B, Wertheim GB, Blood, 2025
CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy
Myers RM, DiNofia AM, Li Y, Diorio C, Liu H, Wertheim GB, Fraietta JA, Gonzalez V, Plesa G, Siegel DL, Iannone E, Shinehouse L, Brogdon JL, Taylor C, Jadlowsky JK, Hexner EO, Engels B, Baniewicz D, Callahan C, Ruella M, Aplenc R, Barz Leahy A, McClory SE, Rheingold SR, Wray L, June CH, Maude SL, Frey NV, Grupp SA, Science Translational Medicine, 2025, PMID:33762369
Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing
Newman H, Clark ME, Wong D, Wu J, Brodeur GM, Hunger SP, Tasian SK, Olson T, Warren JT, Teachey DT, Bona K, Schubert J, Golenberg N, Patel M, Denenberg EH, Fanning EA, Chen J, Luke T, Charles S, Gallo D, Cao K, Fu W, Fan Z, Surrey LF, Wertheim GB, Luo M, MacFarland SP, Li MM, Zhong Y, Haematologica, 2024, PMID:38385299
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression
Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L, Cancer Discovery 14(8): , 2024, PMID:38655899
Identification of TP53 Germline Variants in Pediatric Patients Undergoing Tumor Testing: Strategy and Prevalence
Luo M, Wong D, Zelley K, Wu J, Schubert J, Denenberg EH, Fanning EA, Chen J, Gallo D, Golenberg N, Patel M, Conlin LK, Maxwell KN, Wertheim GB, Surrey LF, Zhong Y, Brodeur GM, MacFarland SP, Li MM, J Natl Cancer Inst, 2024, PMID:38702830
Reinfusion of CD19 CAR T Cells for Relapse Prevention and Treatment in Children With Acute Lymphoblastic Leukemia
Myers RM, Devine K, Li Y, Lawrence S, Barz Leahy A, Liu H, Vernau L, Callahan C, Baniewicz D, Kadauke S, McGuire R, Wertheim GB, Kulikovskaya I, Gonzalez VE, Fraietta JA, DiNofia Am, Hunger SP, Rheingold SR, Aplenc R, June CH, Grupp SA, Wray L, Maude SL, Blood Adv 14(8): 2182-2192, 2024, PMID:38386999
Condensate-promoting ENL Mutation Drives Tumorigenesis in Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression
Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L, Cancer Discov, 2024, PMID:38655899
Maturational Dyssynchrony in Benign B-cell Precursors Following Lymphocyte Depleting Chemotherapy: A potential Pitfall for B-lymphoblastic Leukemia Minimal/Measurable Residual Disease (MRD) Flow Cytometry Analysis
Placek A, Lockhart B, Miller KP, Wertheim GB, Maude SL, Wood BL, Kovach AE, Cytometry B Clin Cytom 106(2): 138-141, 2024, PMID:38247200
FLT3 Tyrosine Kinase Inhibition Modulates PRC2 and Promotes Differentiation in Acute Myeloid Leukemia
Sung PJ, Selvam M, Riedel SS, Xie HM, Bryant K, Manning B, Wertheim GB, Kulej K, Pham L, Bowman RL, Peresie J, Nemeth MJ, Levine RL, Garcia BA, Meyer SE, Sidoli S, Bernt KM, Carroll M, Leukemia 38(2): 291-301, 2024, PMID:38182819
Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing
Newman H, Egan Clark M, Wong D, Wu J, Brodeur GM, Hunger SP, Tasian SK, Olson T, Warren JT, Teachey DT, Bona K, Schubert J, Golenberg N, Patel M, Denenberg EH, Fanning EA, Chen J, Luke T, Charles S, Gallo D, Cao K, Fu W, Fan Z, Surrey LF, Wertheim G, Luo M, MacFarland SP, Li MM, Zhong Y, Haematologica, 2024, PMID:38385299
