Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB. Mol Cell. 2019 Mar 21;73(6): 1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006


Benchmarks, the monthly newsletter featuring preclinical and discovery science at Penn Medicine, chatted with R. Babak Faryabi, PhD, from Pathology and Laboratory Medicine, about a recent Molecular Cell paper, in which Faryabi and co-first authors Jelena Petrovic and Yeqiao Zhou describe how DNA misfolding may affect the biology of triple-negative breast cancer and B-cell lymphoma:  Benchmarks March 2019