PRECISION AND COMPUTATIONAL DIAGNOSTICS

Precision and Computational Diagnostics

The Division of Precision and Computational Diagnostics (PCD) encompasses four laboratories: the Center for Personalized Diagnostics (CPD), the Clinical Cancer Cytogenetics Laboratory, the Molecular Pathology Laboratory, and the Rittenhouse Molecular Laboratory. Together these laboratories provide integrated and cutting-edge precision molecular and genomic diagnostic services for Penn Medicine patients. The Division of PCD is also home to the ACGME-accredited Molecular Genetic Pathology (MGP) fellowship program

The Division focuses on chromosomal and nucleic acid abnormalities that allow Precision Medicine initiatives to target therapies to an individual’s specific disease, resulting in improved outcomes. The growing reliance on traditional molecular and next generation sequencing (NGS)-based assays represents a potential paradigm shift in the practice of pathology, and Penn Medicine is well-positioned to offer its patients access to this exciting and growing field. Relying upon the clinical and scientific excellence of its faculty and staff, the Division remains committed to Penn Medicine's tripartite mission to:

    • Provide outstanding patient care.
    • Provide for the education of physicians and scientists to carry on Penn's legacy of excellence.
    • Contribute toward research that results in discoveries that advance science and translate into new treatment options for patients.

    Accordingly, our clinical laboratories utilize state-of-the-art instrumentation to deliver sophisticated genomic testing for a broad spectrum of cancers, including hematologic and solid tumors, infectious diseases, and constitutional disorders. Educating the next generation of clinicians about this highly complex, rapidly evolving field is vitally important. As such, genomic medicine is strongly emphasized in the training of all Departmental residents and fellows, not just those completing an MGP fellowship. Research in the Division also spans the gamut from sponsored basic research to translational and clinical research.

    The PCD laboratories are accredited and certified by the College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) and licensed by the State of Pennsylvania to conduct high-complexity clinical molecular laboratory tests.

      Our Team:  Faculty
       

      Vivianna Maia Van Deerlin, MD, PhD 
      Professor of Pathology and Laboratory Medicine 
      Interim Director, Division of Precision and Computational Diagnostics 
       
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      Jennifer J.D. Morrissette, PhD 
      Associate Professor of Clinical Pathology and Laboratory Medicine 
      Interim Director, Center for Personalized Diagnostics  
       
      Dr. Morrissette is currently serving as Interim Director of the Center for Personalized Diagnostics, Laboratory Director for the Penn

      Medicine CytoGenomics Laboratories and Scientific Director of the Clinical Cancer Cytogenetics Laboratory. She is dual board certified in Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). She received her PhD in Molecular Biology and Genetics from the State University of New York at Buffalo, completed a postdoctoral fellowship in Molecular Genetics at Harvard Medical School, and completed the ABMGG Fellowship at Children's Hospital of Philadelphia. Her interests are in the application of genomic technologies in oncology for patient management and using genomics to support personalized therapy.
       

      Simon Chen, MD 
      Assistant Professor of Clinical Pathology and Laboratory Medicine 

      Dr. Chen obtained his medical degree from the Washington University
      School of Medicine in St. Louis, and completed his residency in 
      Anatomic and Clinical Pathology and fellowships in Molecular Genetic

      Pathology and Surgical Pathology at Stanford Health Care. He studies the application of molecular genetic pathology to the study of cancer, and in particular the use of molecular genetic biomarkers to support the latest diagnostic and therapeutic innovations in oncology, hematology, anatomic pathology, and hematopathology.
       

      Robert Babak Faryabi, PhD 
      Associate Professor of Pathology and Laboratory Medicine 
      CPD Faculty Lead, Bioinformatics

      Dr. Faryabi is a member of the Abramson Family Cancer Research Institute. After postdoctoral training with Dr. Andre Nussenzweig at

      the NIH Laboratory of Genome Integrity, Dr. Faryabi joined the Perelman School of Medicine at the University of Pennsylvania in June of 2015. His lab explores the genome-wide signatures of replicative stress and the contributions of replication stress-induced genomic lesions to hematological malignancies. The lab employs a combined experimental-computational approach, and develops computational methods based on combinations of big data analytics, mathematical modeling and machine learning algorithms to integrate and interrogate high-dimensional experimental data sets.
       

      Malay Haldar, MD, PhD 
      Associate Professor of Pathology and Laboratory Medicine  

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      Warren S. Pear, MD, PhD 
      Gaylord P. and Mary Louise Harnwell Professor 
      Director, Division of Cancer and Immunobiology
       
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      Salvatore Fortunato Priore, MD, PhD 
      Assistant Professor of Clinical Pathology and Laboratory Medicine 
      Associate Director, Molecular Genetic Pathology Fellowship  
       
      Dr. Priore completed his residency in Anatomic Pathology and a fellowship in Molecular Genetic Pathology at HUP. He received his

      MD and PhD from the University of Rochester as a member of the Medical Scientist Training Program. He completed a postdoctoral fellowship in the laboratory of Yi Xing in the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia. Dr. Priore maintains a significant interest in investigating and developing RNA-based molecular diagnostic testing and is actively involved in teaching and developing novel educational content in molecular pathology and medical humanities. Dr. Priore is a diplomate of the American Board of Pathology.
       

      Kyle G. Rodino, PhD, D(ABMM) 
      Assistant Professor of Clinical Pathology and Laboratory Medicine 
      Assistant Director, Clinical Microbiology Laboratory 
      Director, Rittenhouse Molecular Laboratory  


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      Jacquelyn Roth, PhD, DABMGG 
      Assistant Professor of Clinical Pathology and Laboratory Medicine  

      Dr. Roth is dual board certified in Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). She received her PhD in Genetics from Thomas

      Jefferson University, then completed her two ABMGG fellowships at Children's Hospital of Philadelphia. In 2014, she joined the Molecular Pathology Laboratory at HUP, where she served as the Molecular Development Assistant Director for three years before transitioning into her current role. Dr. Roth's interests include harmonizing the use of cytogenetic and molecular techniques to improve patient diagnostics and laboratory quality control.
       

      Christopher D. Watt, MD, PhD 
      Associate Professor of Clinical Pathology and Laboratory Medicine  
      Program Director, Molecular Genetic Pathology Fellowship  
      Associate Director, Molecular Pathology Laboratory 

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      Guang (Geoff) Yang, MD 
      Assistant Professor of Clinical Pathology and Laboratory Medicine 

      Dr. Yang completed his residency in Anatomic and Clinical Pathology at Loma Linda University Medical Center, followed by his fellowship in Molecular Genetic Pathology at Mayo Clinic, and a

      fellowship in Hematopathology at University of Pennsylvania. He was an instructor in the Molecular Diagnostic Laboratory at University of Minnesota before arriving at HUP. He maintains strong interests in cancer genomics, especially molecular hematopathology, related projects. Dr. Yang is certified by the American Board of Pathology in Combined Anatomic and Clinical Pathology, as well as sub-specialty certification in Hematopathology and Molecular Genetic Pathology.