TRANSFUSION MEDICINE AND THERAPEUTIC PATHOLOGY

Transfusion Medicine and Therapeutic Pathology

Overview

The Division of Transfusion Medicine and Therapeutic Pathology, serving as the therapeutic arm of the Department of Pathology and Laboratory Medicine, comprises the Hospital of the University of Pennsylvania (HUP) blood bank and transfusion service, an immunohematology reference laboratory, an apheresis/infusion unit, a hematopoietic progenitor cell processing laboratory, and two GMP Clinical Cell & Vaccine Production Facilities (CVPF) for the manufacture of novel cell therapies. Its facilities and programs are accredited by the AABB, FACT, and CAP.

The Division’s very active clinical services provide over 65,000 blood and blood products per year to HUP patients through the blood bank and transfusion service while performing 5,000 procedures per year in the apheresis/infusion unit on outpatients and inpatients diagnosed with a variety of hematopoietic, immunologic, oncologic, and genetic disorders. The Division’s hematopoietic progenitor collection laboratory processes and reinfuses stem cells and commercial CAR-T products for several hundred patients per year. The CVPF/CACT GMP facilities currently support the manufacture of novel cell therapies for over 2 dozen Penn Medicine clinical trials in the areas of cell and gene therapy.

The Division consists of nine faculty members who provide medical oversight and consultation for these clinical activities and/or facilitate numerous interdepartmental clinical trials and translational research efforts. Each faculty member has their particular area of academic interest and receives support through funding from the National Institutes of Health (NIH), private industry, and non-profit foundations.

Highlights

• provides comprehensive transfusion medicine physician consultative services 24/7

• provides state-of the-art therapeutic apheresis procedures, including LDL-apheresis

• performs novel hematopoietic stem cell collection and cell processing procedures, including those for hematopoietic cell reconstitution and adoptive immunotherapy including commercially-available FDA-approved CAR-T therapies

• performs the manufacture and release testing of hundreds of engineered cell therapy products per year including novel CAR-T cells, dendritic cell vaccines, CRISPR-edited cells, and other products for treating cancer, autoimmune diseases, and infectious diseases

Faculty

Don L. Siegel, MD, PhD, Director
Nicole Aqui, MD
Vijay Bhoj, MD, PhD
Andrew Fesnak, MD
Carl June, MD
Taku Kambayashi, MD, PhD
Bruce Levine, PhD
Una O’Doherty, MD, PhD
Daniel Powell, PhD


Adjunct Faculty
Margaret Keller, PhD
Senior Director, National Molecular and Genomics Laboratories
Director, American Rare Donor Program

Sandra Nance, MS, MT (ASCP) SBB
Emeritus Senior Director, Immunohematology Reference Laboratory (IRL), Penn-Jersey Region, American Red Cross Blood Services

 


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Transfusion Medicine & Therapeutic Pathology
Nicole Alyse Aqui, MD

Associate Professor of Clinical Pathology and Laboratory Medicine

Perelman School of Medicine at the University of Pennsylvania

Vice Chair for Inclusion, Diversity, and Equity

Director, Pathology Residency Training Program

Chief of Transfusion and Apheresis Services


Andrew Fesnak, MD

Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania

Carl H. June, MD

Richard W. Vague Professor in Immunotherapy

Professor of Medicine

Director, Center for Cellular Immunotherapies

Director, Parker Institute for Cancer Immunotherapy

University of Pennsylvania Perelman School of Medicine


Taku Kambayashi, MD, PhD

Associate Professor of Pathology and Laboratory Medicine

University of Pennsylvania Perelman School of Medicine


Bruce L. Levine, PhD

Barbara and Edward Netter Professor in Cancer Gene Therapy

University of Pennsylvania Perelman School of Medicine


Sandra Nance, MS, MT (ASCP) SBB

Senior Director, Immunohematology Reference Laboratory (IRL), Penn-Jersey Region, American Red Cross Blood Services

Adjunct Assistant Professor of Pathology and Laboratory Medicine


Una O'Doherty, MD, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania

Daniel J. Powell Jr., PhD

Associate Professor of Pathology and Laboratory Medicine

Associate Professor of Obstetrics and Gynecology

University of Pennsylvania Perelman School of Medicine


Donald L. Siegel, PhD, MD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Director, Division of Transfusion Medicine and Therapeutic Pathology

Director, Fellowship Program in Transfusion Medicine

Director, Clinical Cell and Vaccine Production Facility (CVPF)

Center for Advanced Cellular Therapeutics (CACT)

University of Pennsylvania Perelman School of Medicine


Constance M. Westhoff, SBB, PhD

Adjunct Assistant Professor of Pathology and Laboratory Medicine

University of Pennsylvania Perelman School of Medicine

Director of Immunohematology, Genomics, and Rare Blood, New York Blood Center


Vijay Bhoj, MD, PhD

Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania