The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a five-year, $10 million renewal of a program project to study the oldest part of the human immune system, the complement system.
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John Lambris, PhD, and Daniel Ricklin, PhD, are co-authors of a recent study describing a possible new way to fight a disease that is currently treatable only with the most expensive drug available for sale in the United States. The research team outlines a strategy based on the complement system, the oldest part of the human immune system, that could turn out to be less costly and more effective for the majority of patients with the rare but life-threatening hematological disorder paroxysmal nocturnal hemoglobinuria (PNH).
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Researchers from the Perelman School of Medicine at the University of Pennsylvania demonstrate for the first time that the immune system influences the skin microbiome. A new study found that the skin microbiome–a collection of microorganisms inhabiting the human body–is governed, at least in part, by an ancient branch of the immune system called complement. In turn, it appears microbes on the skin tweak the complement system, as well as immune surveillance of the skin.
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