Deng Lab
Development and application of new technologies for spatial omics profiling at the cellular level, specifically tools at the intersection of microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells.
Principal Investigator: Yanxiang Deng, PhD
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Haldar Lab
Mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment
Principal Investigator: Malay Haldar, MD, PhD
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Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
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Perelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Stellar-Chance Laboratories, Rm. 605A
422 Curie Blvd.
Philadelphia, PA 19104
Research Expertise
Research Interests:
Our lab's goal is to translate genetics findings from GWAS and sequencing studies of human neurodegenerative disorders into molecular mechanisms of disease, with the aim of identifying actionable target genes.
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Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Hospital of the University of Pennsylvania
7 Gates Building
3400 Spruce Street
Philadelphia, PA 19104
Email: guang.yang@pennmedicine.upenn.edu
Itmat Experience
Cancer genomics, especially molecular hematopathology
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Faryabi Lab
Genome-wide signatures of replicative stress and the contributions of replication stress-induced genomic lesions to hematological malignancies
Principal Investigator: Robert Babak Faryabi, PhD
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Associate Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Associate Program Director, Physician-Scientist Pathway (PSP),
HUP Pathology Residency Program
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Department of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Biomedical Research Building (BRB) II/III, Rm. 413
421 Curie Boulevard
Philadelphia, PA 19104
Tel: 215-573-9704
Fax: 215-746-5511
Email: mhaldar@pennmedicine.upenn.edu
Research in our laboratory is at the intersection of innate immune system and solid tumor biology. Specifically, we study the mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment. MPS is part of the innate immune system and comprises of monocytes, macrophages, and dendritic cells (DC). These cells are functionally, phenotypically, and developmentally heterogeneous with many distinct subsets. We are interested in understanding the molecular basis of this developmental and functional heterogeneity within the MPS. A major focus in our laboratory is to understand the role of MPS within the microenvironment of a group of solid tumors known as sarcomas. DCs and macrophages are thought to play important role in cancer by modulating host-immune responses against the tumor cells, promoting metastasis, angiogenesis, etc. Additionally, the ability of these cells to regulate lymphocyte function makes them an important determinant in the success of cancer immunotherapy. Using a combination of advanced genetically engineered mouse models in conjunction with patient-derived samples, we aim to uncover the molecular pathways underlying tumor-MPS interaction with the overarching goal of targeting them for therapeutic purposes.
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Associate Professor of Pathology and Laboratory Medicine
Assistant Professor of Cancer Biology
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Biomedical Research Building (BRB) II/III, Room 553
421 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-8220
Email: faryabi@pennmedicine.upenn.edu
Itmat Expertise
Cancer Epigenetics
Genome Architecture
Chromatin Biology
Computational Biology
Clinical Expertise
Cancer Genomics
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Associate Professor of Pathology and Laboratory Medicine at Children's Hospital of Philadelphia
Perelman School of Medicine at the University of Pennsylvania
Director, Division of Genomic Diagnostics
Children's Hospital of Philadelphia (CHOP)
Contact Information
Children’s Hospital of Philadelphia
Department of Pathology and Laboratory Medicine
Abramson Pediatric Research Center, Rm. 716C
3615 Civic Center Blvd.
Philadelphia, PA 19104
Tel: 267-426-7885
Email: conlinl@email.chop.edu
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Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Children’s Hospital of Philadelphia
Colket Translational Research Building, Rm. 4054
3501 Civic Center Boulevard
Philadelphia, PA 19104
Tel: 267-426-0311
Email: bassing@pennmedicine.upenn.edu
Research Interests: Elucidate genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.
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Barbara and Edward Netter Professor in Cancer Gene Therapy
Perelman School of Medicine at the University of Pennsylvania
Founding Director, Clinical Cell and Vaccine Production Facility (CVPF)
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Center for Cellular Immunotherapies
Smilow Center for Translational Research, Rm. 8-114
3400 Civic Center Boulevard
Philadelphia, PA 19104
Tel: 215-898-9120
Email: levinebl@pennmedicine.upenn.edu
Cell, gene, and biologic therapy clinical trial development, manufacturing, and testing and lymphocyte growth, activation, and homeostasis
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