Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Perelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Stellar-Chance Laboratories, 6th Floor
422 Curie Boulevard
Philadelphia, PA 19104
Email: Michael.Haney@Pennmedicine.upenn.edu
Alzheimer's disease, CRISPR screens, functional genomics, neuroimmunology, microglia, neurodegeneration, aging, hematopoiesis
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Oldridge Lab
The Oldridge lab studies the intricate spatial biology of intact tissues, combining cutting-edge spatialomic techniques with advanced computational, statistical, and AI-driven analytic methods. These approaches are used to deeply profile tissues with hundreds to thousands of molecular markers in a spatially detailed manner, in order to better understand the molecular, cellular, and structural basis of human health and disease.
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Deng Lab
Development and application of new technologies for spatial omics profiling at the cellular level, specifically tools at the intersection of microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells.
Principal Investigator: Yanxiang Deng, PhD
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Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Department of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Stellar-Chance Laboratories
422 Curie Boulevard, Room 713A
Philadelphia, PA 19104
Email: Yanxiang.Deng@Pennmedicine.upenn.edu
Research Expertise
Spatial omics, Single-cell analysis, Microfluidics
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Haldar Lab
Mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment
Principal Investigator: Malay Haldar, MD, PhD
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Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Director, Division of Genomic Diagnostics
Children's Hospital of Philadelphia
Contact Information
Children’s Hospital of Philadelphia
Department of Pathology and Laboratory Medicine
Division of Genomic Diagnostics
Abramson Pediatric Research Center
3615 Civic Center Boulevard, Room 710A
Philadelphia, PA 19104
Tel: 267-426-1373
Email: yavuz.bayram@pennmedicine.upenn.edu
Clinical Expertise
Genomic Diagnostics
Molecular Genetics
Cytogenetics
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Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Perelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Stellar-Chance Laboratories, Rm. 605A
422 Curie Blvd.
Philadelphia, PA 19104
Research Expertise
Research Interests:
Our lab's goal is to translate genetics findings from GWAS and sequencing studies of human neurodegenerative disorders into molecular mechanisms of disease, with the aim of identifying actionable target genes.
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Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Associate Director, Histocompatibility Testing Laboratory
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Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
7.019 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Tel: 215-615-7789
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Associate Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Associate Program Director, Physician-Scientist Pathway (PSP),
HUP Pathology Residency Program
Contact Information
Department of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Biomedical Research Building (BRB) II/III, Rm. 413
421 Curie Boulevard
Philadelphia, PA 19104
Tel: 215-573-9704
Fax: 215-746-5511
Email: mhaldar@pennmedicine.upenn.edu
Research in our laboratory is at the intersection of innate immune system and solid tumor biology. Specifically, we study the mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment. MPS is part of the innate immune system and comprises of monocytes, macrophages, and dendritic cells (DC). These cells are functionally, phenotypically, and developmentally heterogeneous with many distinct subsets. We are interested in understanding the molecular basis of this developmental and functional heterogeneity within the MPS. A major focus in our laboratory is to understand the role of MPS within the microenvironment of a group of solid tumors known as sarcomas. DCs and macrophages are thought to play important role in cancer by modulating host-immune responses against the tumor cells, promoting metastasis, angiogenesis, etc. Additionally, the ability of these cells to regulate lymphocyte function makes them an important determinant in the success of cancer immunotherapy. Using a combination of advanced genetically engineered mouse models in conjunction with patient-derived samples, we aim to uncover the molecular pathways underlying tumor-MPS interaction with the overarching goal of targeting them for therapeutic purposes.
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Professor of Pathology and Laboratory Medicine
Professor of Genetics
Perelman School of Medicine at the University of Pennsylvania
Chief Scientific Strategy Officer
Director, Raymond G. Perelman Center for Cellular and Molecular Therapeutics
Katherine A High Presidential Scholar Endowed Chair in Cell and Gene Therapy
Children’s Hospital of Philadelphia (CHOP)
Contact Information
Children’s Hospital of Philadelphia
Department of Pathology and Laboratory Medicine
Colket Translational Research Building, Rm. 5060
3501 Civic Center Boulevard
Philadelphia, PA 19104
Tel: 267-426-0929
Fax: 215-590-3660
Email: davidsonbl@chop.edu
Research Expertise
Keywords:
Neurodegenerative Disease; RNA biology; Gene therapy; Animal models; Human treatment
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