Oldridge Lab
The Oldridge lab studies the intricate spatial biology of intact tissues, combining cutting-edge spatialomic techniques with advanced computational, statistical, and AI-driven analytic methods. These approaches are used to deeply profile tissues with hundreds to thousands of molecular markers in a spatially detailed manner, in order to better understand the molecular, cellular, and structural basis of human health and disease.
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Deng Lab
Development and application of new technologies for spatial omics profiling at the cellular level, specifically tools at the intersection of microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells.
Principal Investigator: Yanxiang Deng, PhD
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Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Stellar Chance Laboratories 505A (office) /515 (lab)
422 Curie Boulevard
Philadelphia, PA, 19104
Office: 215-573-9812
Email: manolis.roulis@pennmedicine.upenn.edu
Function and architecture of the mesenchymal microenvironment in tissue homeostasis, immunopathology and cancer
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Dr. Yanxiang Deng has been named the 2023 Blavatnik Regional Awards Laureate in Life Sciences for his work on novel “spatial-omics” tools that provide unique insight into how cells behave relative to their location in a complex tissue.
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Featuring postdoctoral fellow Dr. Mayassa Bou-Dargham, a $25 million gift for a Center for Epilepsy and Neurodevelopmental Disorders, the first cohort of the AABB's certified Advanced Biotherapies Professional (CABP) credential, research grants for Drs. Saba Ghassemi and Christopher Sande, a podcast on laboratory preparedness for the current monkeypox outbreak by Dr. Kyle Rodino, and Dr. Roseann Wu, who joins the American Board of Pathology’s Test Development and Advisory Committee for Cytopathology.
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Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Department of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Stellar-Chance Laboratories
422 Curie Boulevard, Room 713A
Philadelphia, PA 19104
Email: Yanxiang.Deng@Pennmedicine.upenn.edu
Research Expertise
Spatial omics, Single-cell analysis, Microfluidics
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Haldar Lab
Mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment
Principal Investigator: Malay Haldar, MD, PhD
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Assistant Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Hospital of the University of Pennsylvania
7 Gates Building
3400 Spruce Street
Philadelphia, PA 19104
Email: guang.yang@pennmedicine.upenn.edu
Itmat Experience
Cancer genomics, especially molecular hematopathology
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Research Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Perelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Perelman Center for Advanced Medicine
South Tower, 8th Floor
3400 Civic Center Blvd
Philadelphia, PA 19104
Email: bcarreno@upenn.edu
Research & Itmat Expertise
My research interests have centered on questions related to the generation and modulation of anti-tumor human T cell immunity and how these responses can be harnessed to develop better immune therapeutics.
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Faryabi Lab
Genome-wide signatures of replicative stress and the contributions of replication stress-induced genomic lesions to hematological malignancies
Principal Investigator: Robert Babak Faryabi, PhD
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