Oldridge Lab
The Oldridge lab studies the intricate spatial biology of intact tissues, combining cutting-edge spatialomic techniques with advanced computational, statistical, and AI-driven analytic methods. These approaches are used to deeply profile tissues with hundreds to thousands of molecular markers in a spatially detailed manner, in order to better understand the molecular, cellular, and structural basis of human health and disease.
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Deng Lab
Development and application of new technologies for spatial omics profiling at the cellular level, specifically tools at the intersection of microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells.
Principal Investigator: Yanxiang Deng, PhD
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Associate Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Associate Director, Histocompatibility Testing Laboratory
Contact Information
Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
7.019 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Tel: 215-615-7789
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Research Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Perelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Perelman Center for Advanced Medicine
South Tower, 8th Floor
3400 Civic Center Blvd
Philadelphia, PA 19104
Email: bcarreno@upenn.edu
Research & Itmat Expertise
My research interests have centered on questions related to the generation and modulation of anti-tumor human T cell immunity and how these responses can be harnessed to develop better immune therapeutics.
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Lambris Lab
The Lambris Lab consists of an international and interdisciplinary team that investigates the various aspects of innate immunity, and particularly the complement system, in health and disease. The integrated research approach encompasses projects such as the quantitative analysis of protein-protein interactions of complement components, the development of therapeutic complement inhibitors (e.g. Compstatin), complement evasion by human pathogens, and the role of complement in liver regeneration and cancer development.
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Ninety percent of children and adults with acute lymphoblastic leukemia (ALL) who had relapsed multiple times or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy, CTL019, developed at the Perelman School of Medicine at the University of Pennsylvania. The unprecedented results are published this week in The New England Journal of Medicine.
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Construction of a first-of-its-kind Center for Advanced Cellular Therapeutics at Penn Medicine has begun.
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Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Department of Pathology and Laboratory Medicine
Perelman Center for Advanced Medicine
8-111 South Pavilion Extension
3400 Civic Center Boulevard
Philadelphia, PA 19104
Email: vijay.bhoj@pennmedicine.upenn.edu
Research Expertise
Dr. Bhoj's research expertise lies in the area of cellular immunotherapy. In particular, he has experience in preclinical development of immunotherapy that employ engineered immuno-receptors (e.g.
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The latest results of studies involving both adults and children with advanced blood cancers that have failed to respond to standard therapies.
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The peer-reviewed journal Human Gene Therapy is celebrating its 25th anniversary in 2014 by publishing a series of Perspectives by top researchers in the field of cell and gene therapy. Five "Pioneer" scientists from the Perelman School of Medicine at the University of Pennsylvania are among the 21 investigators who will be honored throughout the next 12 months.
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