Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Stellar Chance Laboratories 505A (office) /515 (lab)
422 Curie Boulevard
Philadelphia, PA, 19104
Office: 215-573-9812
Email: manolis.roulis@pennmedicine.upenn.edu
Function and architecture of the mesenchymal microenvironment in tissue homeostasis, immunopathology and cancer
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Haldar Lab
Mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment
Principal Investigator: Malay Haldar, MD, PhD
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Research Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Perelman School of Medicine at the University of Pennsylvania
Department of Pathology and Laboratory Medicine
Perelman Center for Advanced Medicine
South Tower, 8th Floor
3400 Civic Center Blvd
Philadelphia, PA 19104
Email: bcarreno@upenn.edu
Research & Itmat Expertise
My research interests have centered on questions related to the generation and modulation of anti-tumor human T cell immunity and how these responses can be harnessed to develop better immune therapeutics.
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Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Director, Breast Pathology Service
Hospital of the University of Pennsylvania
Contact Information
Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
6 Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Tel: 215-662-2569
Fax: 215-615-0463
Email: ira.bleiweiss@pennmedicine.upenn.edu
Itmat Expertise
Breast pathology diagnosis, breast cancer predictive and prognostic markers
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Associate Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Associate Program Director, Physician-Scientist Pathway (PSP),
HUP Pathology Residency Program
Contact Information
Department of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Biomedical Research Building (BRB) II/III, Rm. 413
421 Curie Boulevard
Philadelphia, PA 19104
Tel: 215-573-9704
Fax: 215-746-5511
Email: mhaldar@pennmedicine.upenn.edu
Research in our laboratory is at the intersection of innate immune system and solid tumor biology. Specifically, we study the mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment. MPS is part of the innate immune system and comprises of monocytes, macrophages, and dendritic cells (DC). These cells are functionally, phenotypically, and developmentally heterogeneous with many distinct subsets. We are interested in understanding the molecular basis of this developmental and functional heterogeneity within the MPS. A major focus in our laboratory is to understand the role of MPS within the microenvironment of a group of solid tumors known as sarcomas. DCs and macrophages are thought to play important role in cancer by modulating host-immune responses against the tumor cells, promoting metastasis, angiogenesis, etc. Additionally, the ability of these cells to regulate lymphocyte function makes them an important determinant in the success of cancer immunotherapy. Using a combination of advanced genetically engineered mouse models in conjunction with patient-derived samples, we aim to uncover the molecular pathways underlying tumor-MPS interaction with the overarching goal of targeting them for therapeutic purposes.
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Two Pathology Department members receive pilot grants for Abramson Cancer Center Sarcoma Program.
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In a study that sheds light on how phospholipid signals are controlled during tumorigenesis, the Chen Lab reports that TIPE3, a newly described oncogenic protein, is the transfer protein of phosphoinositide second messengers that promote cancer.
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Melanoma physicians and researchers from Penn Medicine and The Wistar Institute have been awarded a prestigious $12.1 million NCI SPORE grant.
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The 40th anniversary of the University of Pennsylvania being designated a Comprehensive Cancer Center by the NCI.
The lab of David Weiner, PhD, professor of Pathology and Laboratory Medicine, and colleagues report in Cancer Research this week that the protein IL-33 boosts the immune system of a human papilloma virus animal model of cancer. IL-33 is a cytokine, a small protein that signals immune cells such as T cells to travel to a site of infection or injury.
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