Perelman School of Medicine at the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
Elizabeth M Anderson, Eileen C Goodwin, Anurag Verma, Claudia P Arevalo, Marcus J Bolton, Madison E Weirick, Sigrid Gouma, Christopher M McAllister, Shannon R Christensen, JoEllen Weaver, Phillip Hicks, Tomaz B Manzoni, Oluwatosin Oniyide, Holly Ramage, Divij Mathew, Amy E Baxter, Derek A Oldridge, Allison R Greenplate, Jennifer E Wu, Cécile Alanio, Kurt D'Andrea, Oliva Kuthuru, Jeanette Dougherty, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sokratis A Apostolidis, Alex C Huang, Laura A Vella, E John Wherry, Nuala J Meyer, Sara Cherry, Paul Bates, Daniel J Rader, Scott E Hensley. Cell. Available online 9 February 2021. doi: https://doi.org/10.1016/j.cell.2021.02.010
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
Jonathan B Johnnidis, Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai, Shufei Song, Jesse M Platt, Jason M Schenkel, Mohamed Abdel-Hakeem, Jean-Christophe Beltra, Allison R Greenplate, Mohammed-Alkhatim A Ali, Kito Nzingha, Josephine R Giles, Christelle Harly, John Attanasio, Kristen E Pauken, Bertram Bengsch, Michael A Paley, Vesselin T Tomov, Makoto Kurachi, Dario A A Vignali, Arlene H Sharpe, Steven L Reiner, Avinash Bhandoola, F Bradley Johnson, E John Wherry. Sci Immunol. 2021 Jan 15;6(55):eabe3702. doi: 10.1126/sciimmunol.abe3702.
Doms Lab
Research in the Doms lab utilizes a wide array of cell biological, biochemical, genetic, and immunological techniques to study membrane proteins important in HIV/AIDS pathogenesis as well as relatively new research projects on Rift Valley Fever virus and other members of the bunyavirus family in which we seek to identify host cell pathways that are used by these viruses to infect cells.
Principal Investigator: Robert W. Doms, MD, PhD
Thomas-Tikhonenko Lab
Mechanisms of neoplastic transformation by the Myc family oncoproteins (including c- and N-Myc), in particular Myc-regulated non-coding microRNAs
Principal Investigator: Andrei Thomas-Tikhonenko, PhD
Marks Lab
Regulation and diseases of intracellular protein transport and organelle biogenesis; Regulation of the formation of functional amyloid in organelle biogenesis; Regulation of antigen processing and toll-like receptor signaling by endosomal trafficking pathways.
Principal Investigator: Michael S. Marks, PhD
Argon Lab
Functions of molecular chaperones in modulating cell surface receptors and secreted proteins
Principal Investigator: Yair Argon, PhD
Wells Lab
Cell-intrinsic, molecular mechanisms that T lymphocytes use to decode extracellular signals and translate these into the appropriate immune vs. tolerant responses
Principal Investigator: Andrew D. Wells, PhD
Kambayashi Lab
The Kambayashi lab studies the regulation of T cell responses, regulatory T cell expansion and homeostasis, and Natural killer (NK) cell education and signaling.
Principal Investigator: Taku Kambayashi, MD, PhD
