Faryabi Lab
Genome-wide signatures of replicative stress and the contributions of replication stress-induced genomic lesions to hematological malignancies
Principal Investigator: Robert Babak Faryabi, PhD
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Associate Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Associate Program Director, Physician-Scientist Pathway (PSP),
HUP Pathology Residency Program
Contact Information
Department of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Biomedical Research Building (BRB) II/III, Rm. 413
421 Curie Boulevard
Philadelphia, PA 19104
Tel: 215-573-9704
Fax: 215-746-5511
Email: mhaldar@pennmedicine.upenn.edu
Research in our laboratory is at the intersection of innate immune system and solid tumor biology. Specifically, we study the mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment. MPS is part of the innate immune system and comprises of monocytes, macrophages, and dendritic cells (DC). These cells are functionally, phenotypically, and developmentally heterogeneous with many distinct subsets. We are interested in understanding the molecular basis of this developmental and functional heterogeneity within the MPS. A major focus in our laboratory is to understand the role of MPS within the microenvironment of a group of solid tumors known as sarcomas. DCs and macrophages are thought to play important role in cancer by modulating host-immune responses against the tumor cells, promoting metastasis, angiogenesis, etc. Additionally, the ability of these cells to regulate lymphocyte function makes them an important determinant in the success of cancer immunotherapy. Using a combination of advanced genetically engineered mouse models in conjunction with patient-derived samples, we aim to uncover the molecular pathways underlying tumor-MPS interaction with the overarching goal of targeting them for therapeutic purposes.
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Associate Professor of Pathology and Laboratory Medicine
Assistant Professor of Cancer Biology
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Biomedical Research Building (BRB) II/III, Room 553
421 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-8220
Email: faryabi@pennmedicine.upenn.edu
Itmat Expertise
Cancer Epigenetics
Genome Architecture
Chromatin Biology
Computational Biology
Clinical Expertise
Cancer Genomics
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Professor of Clinical Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Clinical Director, Center for Personalized Diagnostics
Contact Information
Department of Pathology and Laboratory Medicine
3020 Market Street, Suite 220
Philadelphia, PA 19104
Office: 215-898-5578
Fax: 215-898-9817
Email: jemorris@pennmedicine.upenn.edu
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The Molecular Pathology Laboratory specializes in targeted single gene and small panel testing using DNA and/or RNA for a variety of clinical indications in molecular genetics, molecular oncology, identity testing, and molecular virology. Technologies include real-time PCR and reverse transcription PCR, genotyping, methylation analysis, capillary electrophoresis, pyrosequencing, and next generation sequencing.
The Clinical Cancer Cytogenetics Laboratory at Penn Medicine provides genetic testing for chromosome abnormalities associated with cancer. The lab performs conventional chromosome analysis and fluorescence in situ hybridization (FISH) on neoplastic samples. Specimens routinely evaluated include bone marrow, peripheral blood, and lymph nodes. The laboratory also performs FISH testing on paraffin-embedded tissues.
Professor of Pathology and Laboratory Medicine at the
Hospital of the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Contact Information
Hospital of the University of Pennsylvania
Department of Pathology and Laboratory Medicine
7.103 Founders Pavilion
3400 Spruce Street
Philadelphia, PA, 19104
Tel: 215-662-6644
Fax: 215-662-7529
Email: vivianna.vandeerlin@pennmedicine.upenn.edu
Research Expertise
My research interests are focused in the genetics of neurodegenerative diseases, in particular frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD).
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