Perelman School of Medicine at the University of Pennsylvania
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
Pinzone MR, VanBelzen DJ, Weissman S, Bertuccio MP, Cannon L, Venanzi-Rullo E, Migueles S, Jones RB, Mota T, Joseph SB, Groen K, Pasternak AO, Hwang WT, Sherman B, Vourekas A, Nunnari G, O'Doherty U. Nat Commun. 2019 Feb 13;10(1):728. doi: 10.1038/s41467-019-08431-7.
Doms Lab
Research in the Doms lab utilizes a wide array of cell biological, biochemical, genetic, and immunological techniques to study membrane proteins important in HIV/AIDS pathogenesis as well as relatively new research projects on Rift Valley Fever virus and other members of the bunyavirus family in which we seek to identify host cell pathways that are used by these viruses to infect cells.
Principal Investigator: Robert W. Doms, MD, PhD
O'Doherty Lab
HIV, latency, reservoirs, dendritic cells, viral pathogenesis, proviral integration, retrovirus, virology, T cell activation, resting T cells
Principal Investigator: Una O'Doherty, MD, PhD
June Lab
Keywords: T cells, human, gene therapy, genetic engineering, signal transduction. Using the principles of the cellular immune system to develop novel therapies for cancer and chronic infection, the June Lab focuses on the human immune system and study the biology of lymphocytes in order to manipulate their function and development, and then apply this knowledge for potential new avenues of immunotherapy.
Principal Investigator: Carl H. June, MD
Gaulton Lab
Molecular processes that regulate the infection and pathology of retroviruses, such as HIV, the impact of these infections on the immune system, and the detection of these infections using novel imaging and diagnostic approaches
Principal Investigator: Glen N. Gaulton, PhD
Perelman School of Medicine at the University of Pennsylvania
Richard W. Vague Professor in Immunotherapy
Professor of Medicine
Director, Center for Cellular Immunotherapies
Director, Parker Institute for Cancer Immunotherapy
University of Pennsylvania Perelman School of Medicine
Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Vice Dean and Director of Global Health
Professor of Pathology and Laboratory Medicine
Professor of Microbiology
Perelman School of Medicine at the University of Pennsylvania
Chair and Pathologist-in-Chief
Children's Hospital of Philadelphia
