Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing
Hiemenz MC, Kadauke S, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ. PLoS One. 2016 Apr 4;11(4):e0152851. doi: 10.1371/journal.pone.0152851.
Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience
Wei S, Lieberman D, Morrissette JJ, Baloch ZW, Roth DB, McGrath C. Cancer Cytopathol. 2015 Dec 18. | doi: 10.1002/cncy.21666. [Epub ahead of print]
Chemical Modifications Mark Alternatively Spliced and Uncapped Messenger RNAs in Arabidopsis
Vandivier LE, Campos R, Kuksa PP, Silverman IM, Wang LS, Gregory BD. Plant Cell. 2015 Nov 11. [Epub ahead of print] doi: 10.1105/tpc.15.00591
Faryabi Lab
Genome-wide signatures of replicative stress and the contributions of replication stress-induced genomic lesions to hematological malignancies
Principal Investigator: Robert Babak Faryabi, PhD
Associate Professor of Pathology and Laboratory Medicine
Assistant Professor of Cancer Biology
Perelman School of Medicine at the University of Pennsylvania
Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas
Fishbein L, Khare S, Wubbenhorst B, DeSloover D, D'Andrea K, Merrill S, Cho NW, Greenberg RA, Else T, Montone K, LiVolsi V, Fraker D, Daber R, Cohen DL, Nathanson KL. Nat Commun. 2015 Jan 21;6:6140. | doi: 10.1038/ncomms7140
Schellenberg Lab
Genetics of Neurodegenerative Diseases
Principal Investigator: Gerard D. Schellenberg, PhD
Moore Lab
Contribution of failure of normal growth regulatory controls to the development of hematologic malignancies; development of new flow cytometric applications for research and clinical use. This includes basic and translational studies on applications for monitoring receptor/ligand binding, multiparameter functional studies, minimal residual disease detection, stem cell isolation and identification, and transplantation monitoring.
Principal Investigator: Jonni S. Moore, PhD
Lambris Lab
The Lambris Lab consists of an international and interdisciplinary team that investigates the various aspects of innate immunity, and particularly the complement system, in health and disease. The integrated research approach encompasses projects such as the quantitative analysis of protein-protein interactions of complement components, the development of therapeutic complement inhibitors (e.g. Compstatin), complement evasion by human pathogens, and the role of complement in liver regeneration and cancer development.
