Assistant Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Deng Lab
Development and application of new technologies for spatial omics profiling at the cellular level, specifically tools at the intersection of microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells.
Principal Investigator: Yanxiang Deng, PhD
TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease.
Zhang ZY, Harischandra DS, Wang R, Ghaisas S, Zhao JY, McMonagle TP, Zhu G, Lacuarta KD, Song J, Trojanowski JQ, Xu H, Lee VM, Yang X. Science. 2023 Jul 28;381(6656):eadd6696. doi: 10.1126/science.add6696. Epub 2023 Jul 28. PMID: 37499037.
Perelman School of Medicine at the University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
Henderson MX, Sedor S, McGeary I, Cornblath EJ, Peng C, Riddle DM, Li HL, Zhang B, Brown HJ, Olufemi MF, Bassett DS, Trojanowski JQ, Lee VMY. Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult. Neuron. 2020 Mar 4;105(5):822-836.e7. doi: 10.1016/j.neuron.2019.12.004. Epub 2019 Dec 30.
Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex
Kovacs GG, Robinson JL, Perl DP, Lee VM, Trojanowski JQ. Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex. Acta Neuropathol. 2020 Oct;140(4):591-593. doi: 10.1007/s00401-020-02192-0. Epub 2020 Jul 13.
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo
Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathol. 2020 Dec;140(6):831-849. doi: 10.1007/s00401-020-02227-6. Epub 2020 Oct 6.
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
Xu H, O'Reilly M, Gibbons GS, Changolkar L, McBride JD, Riddle DM, Zhang B, Stieber A, Nirschl J, Kim SJ, Hoxha KH, Brunden KR, Schellenberg GD, Trojanowski JQ, Lee VM. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics. Acta Neuropathol. 2021 Feb;141(2):193-215. doi: 10.1007/s00401-020-02253-4. Epub 2021 Jan 1.
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease
Nguyen AT, Wang K, Hu G, Wang X, Miao Z, Azevedo JA, Suh E, Van Deerlin VM, Choi D, Roeder K, Li M, Lee EB. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta Neuropathol. 2020 Oct;140(4):477-493. doi: 10.1007/s00401-020-02200-3. Epub 2020 Aug 25.
