Perelman School of Medicine at the University of Pennsylvania
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Transmission of tauopathy strains is independent of their isoform composition
He Z, McBride JD, Xu H, Changolkar L, Kim SJ, Zhang B, Narasimhan S, Gibbons GS, Guo JL, Kozak M, Schellenberg GD, Trojanowski JQ, Lee VM. Nat Commun. 2020 Jan 7;11(1):7. doi: 10.1038/s41467-019-13787-x.
Perelman School of Medicine at the University of Pennsylvania
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Kunkle BW, Benjamin Grenier-Boley B, […] Trojanowski JQ, Van Deerlin VM, […] Wang LS, Schellenberg GD, Lambert JC, Pericak-Vance MA. Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2. [Epub 2019 Feb 28]
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM. Nature 10 May 2018. doi:10.1038/s41586-018-0104-4
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy
Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM. Nat Neurosci. 2018 Feb 20. doi: 10.1038/s41593-018-0083-7. [Epub ahead of print]
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, Trojanowski JQ, Lee VM. Nat Med. 2017 Dec 4. doi: 10.1038/nm.4443. [Epub ahead of print]
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM et al. Schellenberg GD. Nat Genet. 2017 Jul 17. doi: 10.1038/ng.3916. [Epub ahead of print]
