Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease
Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D; Parkinson’s Progression Markers Initiative (PPMI) PLoS One. 2017 May 17;12(5):e0175674. | doi: 10.1371/journal.pone.0175674. eCollection 2017.
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. PLoS Med. 2017 Mar 21;14(3):e1002258. doi: 10.1371/journal.pmed.1002258. eCollection 2017 Mar.
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis
Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ. Lancet Neurol. 2017 Jan;16(1):55-65. doi: 10.1016/S1474-4422(16)30291-5.
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice
Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM. J Exp Med. 2016 Oct 17. [Epub ahead of print] | doi: 10.1084/jem.20160833
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Cirulli ET, Lasseigne BN, Petrovski S, et al. Science. 2015 Mar 27;347(6229):1436-41. doi: 10.1126/science.aaa3650. Epub 2015 Feb 19.
C9orf72 promoter hypermethylation is neuroprotective
McMillan CT, Russ J, Wood EM, Irwin DJ, Grossman M, McCluskey L, Elman L, Van Deerlin V, Lee EB. Neurology. 2015 March 20 ( ePub ahead of print) | doi: 10.1212/WNL.0000000000001495
Professor of Pathology and Laboratory Medicine
Professor of Genetics
Perelman School of Medicine at the University of Pennsylvania
Chief Scientific Strategy Officer
Director, Raymond G. Perelman Center for Cellular and Molecular Therapeutics
Katherine A High Presidential Scholar Endowed Chair in Cell and Gene Therapy
Children’s Hospital of Philadelphia (CHOP)
Harding Lab
Neurodegenerative Diseases and Neuropathology
Principal Investigator: Brian Harding, DPhil, BMBCh
Wilson Lab
Neurodegenerative disorders, Friedreich ataxia
Principal Investigator: Robert B. Wilson, MD, PhD
Trojanowski Lab
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.).
Principal Investigator: John Q. Trojanowski, MD, PhD
