Schellenberg Lab
Genetics of Neurodegenerative Diseases
Principal Investigator: Gerard D. Schellenberg, PhD
Mourelatos Lab
Biochemical and genetic studies of Ribonucleoproteins (RNPs) with emphasis on small regulatory RNPs such as microRNAs (miRNAs) and piRNAs (Piwi-associated RNAs). Biochemical and genetic studies of RNA dysregulation in the pathogenesis of neurodegeneration.
Principal Investigator: Zissimos Mourelatos, MD
Luk Lab
Role of Protein Misfolding in Parkinson’s disease (PD); PD Drug Discovery; Biology of Midbrain Dopamine Neurons
Investigator: Kelvin C. Luk, PhD
Lee (Virginia) Lab
Biology of tau, synucleins, TDP-43 and amyloid beta precursor proteins (APPs) in health and disease
Principal Investigator: Virginia Man-Yee Lee, PhD
Johnson Lab
Molecular biology of aging, cell senescence, Werner syndrome, telomeres,
recombination, G-quadruplexes, neurodegeneration, transplantation.
Principal Investigator: F. Bradley Johnson, MD, PhD
Brunden Lab
Identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases. This research encompasses target validation, in vitro assay development and optimization, high-throughput compound screening (HTS), and in vivo compound assessment, including pharmacokinetic and pharmacodynamic analyses, safety pharmacology and efficacy testing in neurodegenerative disease models. In addition, we conduct translational research studies to identify new potential drug targets for these neurodegenerative diseases.
Peter C. Nowell, MD Professor
Associate Professor of Genetics
Co-Director, Penn Neurodegeneration Genomics Center
University of Pennsylvania Perelman School of Medicine
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Former Co-Director, Center for Neurodegenerative Disease Research
Former Director, Institute on Aging
Former Director, Alzheimer's Disease Core Center
Former Director, Penn Udall Center for Parkinson's Research
University of Pennsylvania Perelman School of Medicine
Professor of Pathology and Laboratory Medicine
Director, Penn Neurodegeneration Genomics Center
Perelman School of Medicine at the University of Pennsylvania
Professor of Pathology and Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
