Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion
Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T. Science. 2021 Jul 30;373(6554):eabd2893. doi: 10.1126/science.abd2893.
Read the Penn Medicine press release
Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
Su C, Johnson ME, Torres A, Thomas RM, Manduchi E, Sharma P, Mehra P, Le Coz C, Leonard ME, Lu S, Hodge KM, Chesi A, Pippin J, Romberg N, Grant SFA, Wells AD. Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells. Nat Commun. 2020 Jul 3;11(1):3294. doi: 10.1038/s41467-020-17089-5.
Cytokine storm
Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med. 2020 Dec 3;38(23):2255-2273.
Efficacy matters: broadening complement inhibition in COVID-19
Mastellos DC, Skendros P, Calado RT, Risitano AM, Lambris JD. Efficacy matters: broadening complement inhibition in COVID-19. Lancet Rheumatol. 2021 Feb;3(2):e95. doi: 10.1016/S2665-9913(20)30423-9. Epub 2020 Dec 14.
FcRn augments induction of tissue factor activity by IgG-containing immune complexes
Cines DB, Zaitsev S, Rauova L, Rux AH, Stepanova V, Krishnaswamy S, Sarkar A, Kowalska MA, Zhao G, Mast AE, Blumberg LJ, McCrae KR, Poncz M, Hubbard JJ, Pyzik M, Blumberg RS. FcRn augments induction of tissue factor activity by IgG-containing immune complexes. Blood. 2020 Jun 4;135(23):2085-2093. doi: 10.1182/blood.2019001133.
Haldar Lab
Mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment
Principal Investigator: Malay Haldar, MD, PhD
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
Elizabeth M Anderson, Eileen C Goodwin, Anurag Verma, Claudia P Arevalo, Marcus J Bolton, Madison E Weirick, Sigrid Gouma, Christopher M McAllister, Shannon R Christensen, JoEllen Weaver, Phillip Hicks, Tomaz B Manzoni, Oluwatosin Oniyide, Holly Ramage, Divij Mathew, Amy E Baxter, Derek A Oldridge, Allison R Greenplate, Jennifer E Wu, Cécile Alanio, Kurt D'Andrea, Oliva Kuthuru, Jeanette Dougherty, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sokratis A Apostolidis, Alex C Huang, Laura A Vella, E John Wherry, Nuala J Meyer, Sara Cherry, Paul Bates, Daniel J Rader, Scott E Hensley. Cell. Available online 9 February 2021. doi: https://doi.org/10.1016/j.cell.2021.02.010
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
Jonathan B Johnnidis, Yuki Muroyama, Shin Foong Ngiow, Zeyu Chen, Sasikanth Manne, Zhangying Cai, Shufei Song, Jesse M Platt, Jason M Schenkel, Mohamed Abdel-Hakeem, Jean-Christophe Beltra, Allison R Greenplate, Mohammed-Alkhatim A Ali, Kito Nzingha, Josephine R Giles, Christelle Harly, John Attanasio, Kristen E Pauken, Bertram Bengsch, Michael A Paley, Vesselin T Tomov, Makoto Kurachi, Dario A A Vignali, Arlene H Sharpe, Steven L Reiner, Avinash Bhandoola, F Bradley Johnson, E John Wherry. Sci Immunol. 2021 Jan 15;6(55):eabe3702. doi: 10.1126/sciimmunol.abe3702.
Cytokine release syndrome in severe COVID-19
Moore JB, June, CH. Cytokine release syndrome in severe COVID-19. Science. 2020 May 1; 368:473. doi: 10.1126/science.abb8925.
mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
Gaudette BT, Jones DD, Bortnick A, Argon Y, Allman D. Nat Commun. 2020 Feb 5;11(1):723. doi: 10.1038/s41467-019-14032-1.
