mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
Gaudette BT, Jones DD, Bortnick A, Argon Y, Allman D. Nat Commun. 2020 Feb 5;11(1):723. doi: 10.1038/s41467-019-14032-1.
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, Kuri-Cervantes L, Pampena MB, D'Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Ramage H, Cherry S, Hensley SE, Apostolidis SA, Huang AC, Vella LA; UPenn COVID Processing Unit, Betts MR, Meyer NJ, Wherry EJ. Science. 2020 Jul 15;eabc8511. doi: 10.1126/science.abc8511. Online ahead of print.
Penn Medicine news release
Comprehensive mapping of immune perturbations associated with severe COVID-19
Leticia Kuri-Cervantes, M Betina Pampena, Wenzhao Meng, Aaron M Rosenfeld, Caroline A G Ittner, Ariel R Weisman, Roseline S Agyekum, Divij Mathew, Amy E Baxter, Laura A Vella, Oliva Kuthuru, Sokratis A Apostolidis, Luanne Bershaw, Jeanette Dougherty, Allison R Greenplate, Ajinkya Pattekar, Justin Kim, Nicholas Han, Sigrid Gouma, Madison E Weirick, Claudia P Arevalo, Marcus J Bolton, Eileen C Goodwin, Elizabeth M Anderson, Scott E Hensley, Tiffanie K Jones, Nilam S Mangalmurti, Eline T Luning Prak, E John Wherry, Nuala J Meyer, Michael R Betts. Sci Immunol. 2020 Jul 15;5(49):eabd7114. doi: 10.1126/sciimmunol.abd7114.
Penn Medicine news release
c-Rel is a myeloid checkpoint for cancer immunotherapy
Li T, Li X, Zamani A, Wang W, Lee C, Li M, Luo G, Eiler E, Sun H, Ghosh S, Jin J, Murali R, Ruan Q, Shi W, Chen YH. Nat Cancer 1, 507–517(2020). doi: 10.1038/s43018-020-0061-3
Developmental Relationships of Four Exhausted CD8 + T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Beltra JC, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Wherry EJ. Immunity. 2020 May 19;52(5):825-841.e8. doi: 10.1016/j.immuni.2020.04.014. Epub 2020 May 11.
Trib1 regulates T cell differentiation during chronic infection by restraining the effector program
Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, Jordan MS, Pear WS. J Exp Med. 2020 May 4;217(5):e20190888. doi: 10.1084/jem.20190888.
The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans
Johnson JL, Rosenthal RL, Knox JJ, Myles A, Naradikian MS, Madej J, Kostiv M, Rosenfeld AM, Meng W, Christensen SR, Hensley SE, Yewdell J, Canaday DH, Zhu J, McDermott AB, Dori Y, Itkin M, Wherry EJ, Pardi N, Weissman D, Naji A, Prak ETL, Betts MR, Cancro MP. Immunity. 2020 Apr 22. pii: S1074-7613(20)30133-3. doi: 10.1016/j.immuni.2020.03.020. [Epub ahead of print]
John W. Eckman Professor of Medical Science
Professor of Microbiology
Professor of Microbiology in Biochemistry and Biophysics
Scientific Director, High-Throughput Screening Core
Director, Program for Chemogenomic Discovery
Perelman School of Medicine at the University of Pennsylvania
Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade
Richman LP, Vonderheide RH, Rech AJ. Cell Syst. 2019 Oct 8. pii: S2405-4712(19)30307-2. doi: 10.1016/j.cels.2019.08.009. [Epub ahead of print]
Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes
Awasthi S, Hook LM, Pardi N, Wang F, Myles A, Cancro MP, Cohen GH, Weissman D, Friedman HM. Sci Immunol. 2019 Sep 20;4(39). pii: eaaw7083. doi: 10.1126/sciimmunol.aaw7083.
