Wells Lab
Cell-intrinsic, molecular mechanisms that T lymphocytes use to decode extracellular signals and translate these into the appropriate immune vs. tolerant responses
Principal Investigator: Andrew D. Wells, PhD
Hancock Lab
Transplant immunobiology, inflammation and mechanisms of disease: New Co-Stimulation Molecules And Their Function In Vivo
Principal Investigator: Wayne William Hancock, MD, PhD, FRCPA
Kambayashi Lab
The Kambayashi lab studies the regulation of T cell responses, regulatory T cell expansion and homeostasis, and Natural killer (NK) cell education and signaling.
Principal Investigator: Taku Kambayashi, MD, PhD
Pear Lab
Tumor Biology, Development, Stem Cells, Hematopoiesis, Immune Function
Principal Investigator: Warren S. Pear, MD, PhD
O'Doherty Lab
HIV, latency, reservoirs, dendritic cells, viral pathogenesis, proviral integration, retrovirus, virology, T cell activation, resting T cells
Principal Investigator: Una O'Doherty, MD, PhD
Moore Lab
Contribution of failure of normal growth regulatory controls to the development of hematologic malignancies; development of new flow cytometric applications for research and clinical use. This includes basic and translational studies on applications for monitoring receptor/ligand binding, multiparameter functional studies, minimal residual disease detection, stem cell isolation and identification, and transplantation monitoring.
Principal Investigator: Jonni S. Moore, PhD
Luning Prak Lab
Genetics of the antibody repertoire in autoimmunity
Principal Investigator: Eline T. Luning Prak, MD, PhD
Lambris Lab
The Lambris Lab consists of an international and interdisciplinary team that investigates the various aspects of innate immunity, and particularly the complement system, in health and disease. The integrated research approach encompasses projects such as the quantitative analysis of protein-protein interactions of complement components, the development of therapeutic complement inhibitors (e.g. Compstatin), complement evasion by human pathogens, and the role of complement in liver regeneration and cancer development.
June Lab
Keywords: T cells, human, gene therapy, genetic engineering, signal transduction. Using the principles of the cellular immune system to develop novel therapies for cancer and chronic infection, the June Lab focuses on the human immune system and study the biology of lymphocytes in order to manipulate their function and development, and then apply this knowledge for potential new avenues of immunotherapy.
Principal Investigator: Carl H. June, MD
Jordan Lab
T cell signal transduction and its regulation of T cell differentiation
Investigator: Martha S. Jordan, PhD
