High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity
Doerner SK, Reiss ES, Leung ES, Ko JS, Heaney JD, Berger NA, Lambris JD, Nadeau JH. Mol Cancer Res. 2016 Aug 17. pii: molcanres.0153.2016. [Epub ahead of print] | doi: 10.1158/1541-7786.MCR-16-0153
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C8, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. Nature. 2016 Aug 15. doi: 10.1038/nature19346. [Epub ahead of print]
Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3
Maekawa T, Briones RA, Resuello RR, Tuplano JV, Hajishengallis E, Kajikawa T, Koutsogiannaki S, Garcia CA, Ricklin D, Lambris JD, Hajishengallis G. J Clin Periodontol. 2016 Jan 5 | doi: 10.1111/jcpe.12507. [Epub ahead of print]
Atomic description of the immune complex involved in heparin-induced thrombocytopenia
Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB, Greene MI. Nat Commun. 2015 Sep 22;6:8277. doi: 10.1038/ncomms9277.
Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria
Lin Z, Schmidt CQ, Koutsogiannaki S, Ricci P, Risitano AM, Lambris JD, Ricklin D. Blood. 2015 Jun 16. [Epub ahead of print] doi: 10.1182/blood-2015-02-625871
Associate Professor of Pathology and Laboratory Medicine
Perelman School of Medicine at the University of Pennsylvania
Associate Program Director, Physician-Scientist Pathway (PSP),
HUP Pathology Residency Program
High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning
Reshef R, Huffman AP, Gao A, Luskin MR, Frey NV, Gill SI, Hexner EO, Kambayashi T, Loren AW, Luger SM, Mangan JK, Nasta SD, Richman PL, Sell M, Stadtmauer EA, Vonderheide RH, Mick R, Porter DL. J Clin Oncol 2015 Jun 8. [Epub ahead of print] doi: 10.1200/JCO.2014.60.1203
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
Twyman-Saint Victor C, Andrew J. Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Robert H. Vonderheide RH, Minn AJ. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 2015 Mar 9 (ePub ahead of print) | doi: 10.1038/nature14292
Choi Lab
Molecular analysis of the osteoimmune system
Principal Investigator: Yongwon Choi, PhD
Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters
Reis ES, DeAngelis RA, Chen H, Resuello RRG, Ricklin D, Lambris JD. Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters. Immunobiology. 2014 Nov 3. [Epub ahead of print] | doi: 10.1016/j.imbio.2014.10.026
